THE CONVERSION OF PHENYLALANINE TO TYROSINE

尽管肝苯丙氨酸羟化酶以二聚体的混合物形式存在 和四聚体，它是催化活性的二聚体形式。 苯丙氨酸对苯丙氨酸羟基酶的激活作用 通过增加单体之间的相互作用。 人类羟基酶处于高度激活状态。人类 苯丙氨酸羟基酶对 苯丙氨酸。

Although hepatic phenylalanine hydroxylase occurs as a mixture of dimer and tetramers, it is the dimeric form that is catalytically active. Activation of phenylalanine hydroxylase by phenylalanine is accompanied by an increased interaction between the monomers. The human hydroxylase is in a highly activated state. Human phenylalanine hydroxylase has an unexpectedly high affinity for phenylalanine.