Diversity of the masticatory apparatus among extant rodents: 3D analysis and modeling of form and function

现存啮齿类动物咀嚼器官的多样性:形状和功能的 3D 分析和建模

基本信息

  • 批准号:
    NE/G001979/1
  • 负责人:
  • 金额:
    $ 3.25万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2009
  • 资助国家:
    英国
  • 起止时间:
    2009 至 无数据
  • 项目状态:
    已结题

项目摘要

Rodents form the largest order (Rodentia) of mammals comprising well over two thousand species. However, despite their diversity, all rodents can be assigned to one of just three groups based on the arrangement of the jaw muscles: the squirrel-like rodents (sciuromorphs), the guinea pig-like rodents (hystricomorphs), and the rat-like rodents (myomorphs). Two groups, the sciuromorphs and hystricomorphs, also have distinct modes of feeding - the former are predominantly gnawers whereas the latter are mostly chewers. The myomorphs are generalists and do not specialise in their mode of feeding. This raises a very interesting question - are the differing feeding behaviours and related muscle arrangements driving skeletal form in the rodent skull? Surprisingly, no one has addressed this fundamentally important question, even though rodents are one of the most important groups on the planet in terms of biological research, biodiversity, and environmental health. Our aim is to draw on our collective expertise in imaging, computer modelling and evolutionary biology to address the rodent form and function question by way of three core hypotheses: Firstly, it is hypothesised that the two extreme modes of feeding found among rodents (chewing and gnawing) are associated with notably different patterns of stress and strain across the skull. It is also predicted that rats, which are adapted to both modes of feeding, will show an intermediate pattern of stress and strain. Secondly, it is hypothesised that the different stress/strain patterns will explain differences in the shape of the skull and the attachment points of the muscles between the three groups. The alternative scenario is that other factors such as brain size, body size or evolutionary history are having an equal or greater effect on the skull shape than feeding. Lastly, it is predicted that rats either develop from sciuromorph muscles on a hystricomorph skull or hystricomorph muscles on a sciuromorph skull. This predicts that by modifying guinea pig and squirrel models, we will be able to create a virtual model that closely resembles a rat. To test the above hypotheses, three-dimensional digital models will be reconstructed from computed tomography (CT) and magnetic resonance imaging (MRI) scans. The models will be analysed using finite element analysis (FEA) - a technique that predicts deformation, strain and stress in a digital structure. These techniques will be used because they are non-invasive, thereby removing the need for live animal experimentation, they provide spatially co-registered data, and also because the digital models can be manipulated to test particular hypotheses or to produce hypothetical morphologies not normally found in nature. The results of this project will lead to a greater understanding of the effect of feeding on the rodent skull and the constraints imposed by the jaw muscles. This will help explain the exceptional evolutionary success of the order Rodentia amongst the mammals, and, in particular, the success of the rats and mice within the rodents. We anticipate that the research will benefit environmental and evolutionary biologists interested in modes of biodiversity and mammalian speciation.
啮齿动物是哺乳动物中最大的目(啮齿目),包括2000多个物种。然而,尽管它们的多样性,所有的啮齿类动物都可以根据颌骨肌肉的排列分为三组:松鼠样啮齿类动物(sciuromorphs),豚鼠样啮齿类动物(hystricomorphs)和大鼠样啮齿类动物(myomorphs)。有两个族群,松鼠形和豪猪形,也有不同的进食模式-前者主要是啃食者,而后者主要是咀嚼者。Myomorphs是多面手,并不专注于他们的进食模式。这提出了一个非常有趣的问题--不同的进食行为和相关的肌肉排列是否驱动了啮齿动物头骨中的骨骼形式?令人惊讶的是,没有人解决这个根本性的重要问题,尽管啮齿动物是地球上生物研究,生物多样性和环境健康方面最重要的群体之一。我们的目标是利用我们在成像,计算机建模和进化生物学方面的集体专业知识,通过三个核心假设来解决啮齿动物的形式和功能问题:首先,假设啮齿动物中发现的两种极端进食模式(咀嚼和啃咬)与头骨上明显不同的应力和应变模式有关。据预测,适应这两种喂养方式的大鼠将表现出一种中间的应激和紧张模式。其次,假设不同的应力/应变模式将解释三组之间头骨形状和肌肉附着点的差异。另一种情况是,其他因素,如大脑大小,身体大小或进化历史,对头骨形状的影响与进食相同或更大。最后,据预测,大鼠要么从hystricomorph头骨上的sciuromorph肌肉发育而来,要么从sciuromorph头骨上的hystricomorph肌肉发育而来。这预示着,通过修改豚鼠和松鼠模型,我们将能够创建一个非常类似于大鼠的虚拟模型。为了检验上述假设,将从计算机断层扫描(CT)和磁共振成像(MRI)扫描重建三维数字模型。这些模型将使用有限元分析(FEA)进行分析-这是一种预测数字结构中的变形,应变和应力的技术。将使用这些技术,因为它们是非侵入性的,从而消除了对活体动物实验的需要,它们提供了空间共配准的数据,并且还因为可以操纵数字模型来测试特定的假设或产生自然界中通常不存在的假设形态。该项目的结果将导致更好地了解啮齿动物头骨上的进食效果和下颌肌肉施加的限制。这将有助于解释啮齿目动物在哺乳动物中的特殊进化成功,特别是啮齿类动物中大鼠和小鼠的成功。我们预计,这项研究将有利于对生物多样性和哺乳动物物种形成模式感兴趣的环境和进化生物学家。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Functional evolution of the feeding system in rodents.
  • DOI:
    10.1371/journal.pone.0036299
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Cox PG;Rayfield EJ;Fagan MJ;Herrel A;Pataky TC;Jeffery N
  • 通讯作者:
    Jeffery N
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Emily Rayfield其他文献

LB-044 - The effect of Yoda1 and fibroblast growth factor 18 on a novel in vitro 3-Dimensional human chondrocyte model
  • DOI:
    10.1016/j.joca.2024.03.046
  • 发表时间:
    2024-06-01
  • 期刊:
  • 影响因子:
  • 作者:
    Sophie Gilbert;Ana Carregosa;Andreas Heil;Sharon Dewitt;Christine Hammond;Emily Rayfield;Daniel Aeschlimann;Emma J. Blain
  • 通讯作者:
    Emma J. Blain
Extracellular matrix assembly stress initiates emDrosophila/em central nervous system morphogenesis
细胞外基质组装应激启动果蝇中枢神经系统形态发生
  • DOI:
    10.1016/j.devcel.2023.03.019
  • 发表时间:
    2023-05-22
  • 期刊:
  • 影响因子:
    8.700
  • 作者:
    Eduardo Serna-Morales;Besaiz J. Sánchez-Sánchez;Stefania Marcotti;Angus Nichols;Anushka Bhargava;Anca Dragu;Liisa M. Hirvonen;María-del-Carmen Díaz-de-la-Loza;Matyas Mink;Susan Cox;Emily Rayfield;Rachel M. Lee;Chad M. Hobson;Teng-Leong Chew;Brian M. Stramer
  • 通讯作者:
    Brian M. Stramer
Artificial intelligence in paleontology
古生物学中的人工智能
  • DOI:
    10.1016/j.earscirev.2024.104765
  • 发表时间:
    2024-05-01
  • 期刊:
  • 影响因子:
    10.000
  • 作者:
    Congyu Yu;Fangbo Qin;Akinobu Watanabe;Weiqi Yao;Ying Li;Zichuan Qin;Yuming Liu;Haibing Wang;Qigao Jiangzuo;Allison Y. Hsiang;Chao Ma;Emily Rayfield;Michael J. Benton;Xing Xu
  • 通讯作者:
    Xing Xu

Emily Rayfield的其他文献

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{{ truncateString('Emily Rayfield', 18)}}的其他基金

Eat, heat and listen: on becoming a mammal
吃、加热和听:成为哺乳动物
  • 批准号:
    NE/X001504/1
  • 财政年份:
    2023
  • 资助金额:
    $ 3.25万
  • 项目类别:
    Research Grant
Form, function and development of the amniote skull: a case study using lepidosaurs
羊膜动物头骨的形式、功能和发育:鳞龙类案例研究
  • 批准号:
    BB/W00867X/1
  • 财政年份:
    2022
  • 资助金额:
    $ 3.25万
  • 项目类别:
    Research Grant
Skull evolution and the terrestrialization and radiation of tetrapods
头骨进化与四足动物的陆地化和辐射
  • 批准号:
    NE/P013090/1
  • 财政年份:
    2017
  • 资助金额:
    $ 3.25万
  • 项目类别:
    Research Grant
Understanding the functional evolution of the mammalian middle ear and jaw joint across the cynodont-mammaliaform transition
了解哺乳动物中耳和下颌关节在犬齿兽-哺乳类过渡过程中的功能进化
  • 批准号:
    NE/K01496X/1
  • 财政年份:
    2013
  • 资助金额:
    $ 3.25万
  • 项目类别:
    Research Grant
The morpho-functional evolution of bird beaks and skulls
鸟喙和头骨的形态功能进化
  • 批准号:
    BB/I011668/1
  • 财政年份:
    2011
  • 资助金额:
    $ 3.25万
  • 项目类别:
    Research Grant
Applying synchrotron X-ray microtomography to a study of Morganucodon and Kuehneotherium: two of the earliest stem mammals.
将同步加速器 X 射线显微断层扫描应用于摩根古龙 (Morganucodon) 和 Kuehneotherium 的研究:两种最早的干哺乳动物。
  • 批准号:
    NE/E010431/1
  • 财政年份:
    2007
  • 资助金额:
    $ 3.25万
  • 项目类别:
    Research Grant
Cranial functional morphology of Archaeopteryx and the biomechanical triggers of avian evolution
始祖鸟的颅骨功能形态和鸟类进化的生物力学触发因素
  • 批准号:
    NE/E001076/1
  • 财政年份:
    2006
  • 资助金额:
    $ 3.25万
  • 项目类别:
    Research Grant

相似海外基金

Functional development within the mammalian masticatory apparatus: an investigation into feeding capabilities with changing diets
哺乳动物咀嚼器官的功能发育:饮食变化下摄食能力的研究
  • 批准号:
    2751618
  • 财政年份:
    2022
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    $ 3.25万
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Characteristic of the masticatory apparatus in the type2 diabetes model rats caused by soft diet feeding.
软食喂养2型糖尿病模型大鼠咀嚼器官的特征
  • 批准号:
    17K01905
  • 财政年份:
    2017
  • 资助金额:
    $ 3.25万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Collaborative Research: Normal and pathological covariation in the masticatory apparatus of anthropoid primates
合作研究:类人灵长类咀嚼器官的正常和病理协变
  • 批准号:
    1551722
  • 财政年份:
    2016
  • 资助金额:
    $ 3.25万
  • 项目类别:
    Standard Grant
Collaborative Research: Normal and pathological covariation in the anthropoid masticatory apparatus
合作研究:类人猿咀嚼器官的正常和病理协变
  • 批准号:
    1551766
  • 财政年份:
    2016
  • 资助金额:
    $ 3.25万
  • 项目类别:
    Standard Grant
Collaborative Research: Normal and pathological covariation in the masticatory apparatus of anthropoid primates
合作研究:类人灵长类咀嚼器官的正常和病理协变
  • 批准号:
    1551669
  • 财政年份:
    2016
  • 资助金额:
    $ 3.25万
  • 项目类别:
    Standard Grant
Diversity of the masticatory apparatus among extant rodents: 3D analysis and modeling of form and function
现存啮齿类动物咀嚼器官的多样性:形状和功能的 3D 分析和建模
  • 批准号:
    NE/G002207/1
  • 财政年份:
    2009
  • 资助金额:
    $ 3.25万
  • 项目类别:
    Research Grant
Diversity of the masticatory apparatus among extant rodents: 3D analysis and modeling of form and function
现存啮齿类动物咀嚼器官的多样性:形状和功能的 3D 分析和建模
  • 批准号:
    NE/G001952/1
  • 财政年份:
    2009
  • 资助金额:
    $ 3.25万
  • 项目类别:
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FOR 771: Function and Performance Enhancement in the Mammalian Dentition - Phylogenetic and Ontogenetic Impact on the Masticatory Apparatus
FOR 771:哺乳动物牙列的功能和性能增强 - 系统发育和个体发育对咀嚼器官的影响
  • 批准号:
    25905019
  • 财政年份:
    2007
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    $ 3.25万
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    Research Units
Morphological relationship between food・foodintake and the masticatory apparatus in Primates
灵长类食物·食物摄入与咀嚼器官的形态关系
  • 批准号:
    08640907
  • 财政年份:
    1996
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    $ 3.25万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Dissertation Research: Biomechanics of the Hominoid Masticatory Apparatus
论文研究:类人猿咀嚼器的生物力学
  • 批准号:
    9316717
  • 财政年份:
    1993
  • 资助金额:
    $ 3.25万
  • 项目类别:
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