TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
批准号:
6169311
负责人:
Sam R Telford
金额:
$25.42万
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-08-01 至 2002-07-31
关键词:
Ehrlichia Ixodes Lyme disease arthropod borne communicable disease borreliosis clinical research disease /disorder proneness /risk disease reservoirs disease vectors ehrlichiosis epizootiology field study host organism interaction human subject immunocytochemistry intracellular parasitism laboratory mouse polymerase chain reaction serology /serodiagnosis tissue resource /registry vertical transmission vole western blottings zoonosis
中文摘要
我们建议确定是否人粒细胞因子
新英格兰沿海地区的埃立克体病与莱姆病共同传播
疾病和人类巴贝斯虫病。一种埃里希体,
在上中西部感染人类的病毒是从南图克特分离的
通过将她的血液接种到实验室小鼠中来观察。此代理
稳定感染完整或脾切除的远系和近交系小鼠,以及
白足鹿鼠是疏螺旋体属的主要地方性宿主,
美国东北部的伯氏啮小蜂和小蜂
以实验感染小鼠为幼虫的蜱虫传播了
将该试剂用于未感染小鼠,明确证明载体
能力。我们将以一种方式来确定它的永久性。
HGE代理在沿海马萨诸塞州,重点是假设,
疏螺旋体、巴贝虫和埃利希虫共享一个地方性循环,
啮齿动物水库和鹿蜱载体; 2)完善我们的方法,
检测脊椎动物和蜱宿主中HGE感染的证据,
比较基于显微镜的方法(包括免疫组织化学)与
聚合酶链反应分析;以及3)描述公共卫生
这种新出现的人畜共患病相对于莱姆病的负担,
在不同的沿海新英格兰社区的巴贝虫病,通过回顾
大型血清库分析以及前瞻性队列研究。
总之,这些研究旨在描述人类如何成为
感染了这种新的人畜共患病原体,并提供了基础,
干预
英文摘要
We propose to determine whether the agent of human granulocytic
ehrlichiosis in coastal New England is cotransmitted with those of Lyme
disease and human babesiosis. An Ehrlichia with molecular identity to one
infecting humans in the upper Midwest was isolated from a Nantucket
resident by subinoculation of her blood into laboratory mice. This agent
stably infects intact or splenectomised outbred and inbred mice, as well
as Peromyscus leucopus, the main enzootic reservoir of Borrelia
burgdorferi and Babesia microti in the northeastern U.S. Nymphal deer
ticks that had fed as larvae on experimentally infected mice transmitted
the agent to uninfected mice, definitively demonstrating vector
competence. Thus, we shall 1) determine the mode of perpetuation of the
HGE agent in coastal Massachusetts, focusing on the hypothesis that
borreliae, babesiae, and ehrlichiae share an enzootic cycle between
rodent reservoirs and the deer tick vector; 2) refine our methods for
detecting evidence of HGE infection in vertebrate and tick hosts,
comparing microscopy-based methods (including immunohistochemistry) with
a polymerase chain reaction assay; and 3) describe the public health
burden of this emergent zoonosis relative to that of Lyme disease and
babesiosis in various coastal New England communities, by retrospective
analysis of a large serum bank, as well as by prospective cohort study.
Together, these studies are designed to describe how humans become
infected by this new zoonotic agent, and provide a basis for
intervention.
期刊论文(6)
专著(0)
科研奖励(0)
会议论文
NERBL Core 3: Biocontainment Research Support Services
-
批准号:10793934
-
项目类别:
-
资助金额:$42.36万
-
财政年份:2023
-
负责人:Sam R Telford
-
依托单位:
NERBL Core 1: Facility Management, Maintenance and Operations
-
批准号:10793932
-
项目类别:
-
资助金额:$89.62万
-
财政年份:2023
-
负责人:Sam R Telford
-
依托单位:
NERBL Core 2: BSL-3 Practices
-
批准号:10793933
-
项目类别:
-
资助金额:$111.53万
-
财政年份:2023
-
负责人:Sam R Telford
-
依托单位:
Facility Upgrade for the New England Regional Biosafety Laboratory
-
批准号:10630474
-
项目类别:
-
资助金额:$383.97万
-
财政年份:2022
-
负责人:Sam R Telford
-
依托单位:
Facility Upgrade for the New England Regional Biosafety Laboratory
-
批准号:10394468
-
项目类别:
-
资助金额:$332.29万
-
财政年份:2021
-
负责人:Sam R Telford
-
依托单位:
Retrotransposon assay for tick host bloodmeal identification
-
批准号:9756305
-
项目类别:
-
资助金额:$40.78万
-
财政年份:2018
-
负责人:Sam R Telford
-
依托单位:
Retrotransposon assay for tick host bloodmeal identification
-
批准号:10211119
-
项目类别:
-
资助金额:$40.78万
-
财政年份:2018
-
负责人:Sam R Telford
-
依托单位:
Retrotransposon assay for tick host bloodmeal identification
-
批准号:9976450
-
项目类别:
-
资助金额:$40.78万
-
财政年份:2018
-
负责人:Sam R Telford
-
依托单位:
Perpetuation of Francisella tularensis
-
批准号:7168845
-
项目类别:
-
资助金额:$38.15万
-
财政年份:2006
-
负责人:Sam R Telford
-
依托单位:
Perpetuation of Francisella tularensis
-
批准号:7350858
-
项目类别:
-
资助金额:$37.42万
-
财政年份:2006
-
负责人:Sam R Telford
-
依托单位:
Perpetuation of Francisella tularensis
-
批准号:7036059
-
项目类别:
-
资助金额:$39.29万
-
财政年份:2006
-
负责人:Sam R Telford
-
依托单位:
Perpetuation of Francisella tularensis
-
批准号:7761710
-
项目类别:
-
资助金额:$37.05万
-
财政年份:2006
-
负责人:Sam R Telford
-
依托单位:
Perpetuation of Francisella tularensis
-
批准号:7563925
-
项目类别:
-
资助金额:$37.42万
-
财政年份:2006
-
负责人:Sam R Telford
-
依托单位:
Proximal determinants of risk for tularemia outbreaks
-
批准号:6804696
-
项目类别:
-
资助金额:$23.78万
-
财政年份:2003
-
负责人:Sam R Telford
-
依托单位:
Proximal determinants of risk for tularemia outbreaks
-
批准号:6679462
-
项目类别:
-
资助金额:$23.78万
-
财政年份:2003
-
负责人:Sam R Telford
-
依托单位:
TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
-
批准号:2457850
-
项目类别:
-
资助金额:$22.99万
-
财政年份:1996
-
负责人:Sam R Telford
-
依托单位:
TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
-
批准号:2076114
-
项目类别:
-
资助金额:$22.4万
-
财政年份:1996
-
负责人:Sam R Telford
-
依托单位:
TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
-
批准号:2887096
-
项目类别:
-
资助金额:$25.03万
-
财政年份:1996
-
负责人:Sam R Telford
-
依托单位:
TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
-
批准号:2672635
-
项目类别:
-
资助金额:$23.98万
-
财政年份:1996
-
负责人:Sam R Telford
-
依托单位:
RESERVOIR IMMUNITY IN LYME DISEASE VECTOR COMPETENCE
-
批准号:2887024
-
项目类别:
-
资助金额:$11.66万
-
财政年份:1995
-
负责人:Sam R Telford
-
依托单位:
海外基金