TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
批准号:
6169311
负责人:
Sam R Telford
金额:
$25.42万
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-08-01 至 2002-07-31
关键词:
Ehrlichia Ixodes Lyme disease arthropod borne communicable disease borreliosis clinical research disease /disorder proneness /risk disease reservoirs disease vectors ehrlichiosis epizootiology field study host organism interaction human subject immunocytochemistry intracellular parasitism laboratory mouse polymerase chain reaction serology /serodiagnosis tissue resource /registry vertical transmission vole western blottings zoonosis
中文摘要
我们建议确定人类粒细胞因子是否
新英格兰沿海地区的埃立克体病与莱姆病是共传播的
疾病和人类巴贝斯虫病。一种与One分子同源的埃立克氏菌
在中西部上段感染人类的人是从楠塔基特分离出来的
通过将她的血液亚接种到实验室的小鼠体内。这位代理
稳定地感染完整的或切除脾的近交系和近交系小鼠
作为疏螺旋体的主要地方性宿主--白色Permyscus
美国东北部若虫的Burgdorferi和Babesia microti
在实验感染的小鼠身上喂食幼虫的扁虱传播
该试剂对未感染的小鼠,明确展示了媒介
能力。因此,我们将1)确定永久保存的模式
马萨诸塞州沿海地区的HGE代理,重点是假设
疏螺旋体、巴贝斯和埃立克次体之间的地方性循环
啮齿动物储藏室和鹿虱媒介;2)改进我们的方法
在脊椎动物和壁虱宿主中检测到HGE感染的证据,
基于显微镜的方法(包括免疫组织化学)与
聚合酶链式反应分析;以及3)描述公共健康
这一新发人畜共患病与莱姆病和
新英格兰沿海不同社区的巴贝斯虫病
对一个大型血清库的分析,以及前瞻性队列研究。
总之,这些研究旨在描述人类是如何成为
感染了这种新的人畜共患病病原体,并为
干预。
英文摘要
We propose to determine whether the agent of human granulocytic
ehrlichiosis in coastal New England is cotransmitted with those of Lyme
disease and human babesiosis. An Ehrlichia with molecular identity to one
infecting humans in the upper Midwest was isolated from a Nantucket
resident by subinoculation of her blood into laboratory mice. This agent
stably infects intact or splenectomised outbred and inbred mice, as well
as Peromyscus leucopus, the main enzootic reservoir of Borrelia
burgdorferi and Babesia microti in the northeastern U.S. Nymphal deer
ticks that had fed as larvae on experimentally infected mice transmitted
the agent to uninfected mice, definitively demonstrating vector
competence. Thus, we shall 1) determine the mode of perpetuation of the
HGE agent in coastal Massachusetts, focusing on the hypothesis that
borreliae, babesiae, and ehrlichiae share an enzootic cycle between
rodent reservoirs and the deer tick vector; 2) refine our methods for
detecting evidence of HGE infection in vertebrate and tick hosts,
comparing microscopy-based methods (including immunohistochemistry) with
a polymerase chain reaction assay; and 3) describe the public health
burden of this emergent zoonosis relative to that of Lyme disease and
babesiosis in various coastal New England communities, by retrospective
analysis of a large serum bank, as well as by prospective cohort study.
Together, these studies are designed to describe how humans become
infected by this new zoonotic agent, and provide a basis for
intervention.
期刊论文(6)
专著(0)
科研奖励(0)
会议论文
NERBL Core 3: Biocontainment Research Support Services
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批准号:10793934
-
项目类别:
-
资助金额:$42.36万
-
财政年份:2023
-
负责人:Sam R Telford
-
依托单位:
NERBL Core 1: Facility Management, Maintenance and Operations
-
批准号:10793932
-
项目类别:
-
资助金额:$89.62万
-
财政年份:2023
-
负责人:Sam R Telford
-
依托单位:
NERBL Core 2: BSL-3 Practices
-
批准号:10793933
-
项目类别:
-
资助金额:$111.53万
-
财政年份:2023
-
负责人:Sam R Telford
-
依托单位:
Facility Upgrade for the New England Regional Biosafety Laboratory
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批准号:10630474
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项目类别:
-
资助金额:$383.97万
-
财政年份:2022
-
负责人:Sam R Telford
-
依托单位:
Facility Upgrade for the New England Regional Biosafety Laboratory
-
批准号:10394468
-
项目类别:
-
资助金额:$332.29万
-
财政年份:2021
-
负责人:Sam R Telford
-
依托单位:
Retrotransposon assay for tick host bloodmeal identification
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批准号:9756305
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项目类别:
-
资助金额:$40.78万
-
财政年份:2018
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负责人:Sam R Telford
-
依托单位:
Retrotransposon assay for tick host bloodmeal identification
-
批准号:10211119
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项目类别:
-
资助金额:$40.78万
-
财政年份:2018
-
负责人:Sam R Telford
-
依托单位:
Retrotransposon assay for tick host bloodmeal identification
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批准号:9976450
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项目类别:
-
资助金额:$40.78万
-
财政年份:2018
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负责人:Sam R Telford
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依托单位:
Perpetuation of Francisella tularensis
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批准号:7350858
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项目类别:
-
资助金额:$37.42万
-
财政年份:2006
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负责人:Sam R Telford
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依托单位:
Perpetuation of Francisella tularensis
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批准号:7168845
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项目类别:
-
资助金额:$38.15万
-
财政年份:2006
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负责人:Sam R Telford
-
依托单位:
Perpetuation of Francisella tularensis
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批准号:7036059
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项目类别:
-
资助金额:$39.29万
-
财政年份:2006
-
负责人:Sam R Telford
-
依托单位:
Perpetuation of Francisella tularensis
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批准号:7761710
-
项目类别:
-
资助金额:$37.05万
-
财政年份:2006
-
负责人:Sam R Telford
-
依托单位:
Perpetuation of Francisella tularensis
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批准号:7563925
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项目类别:
-
资助金额:$37.42万
-
财政年份:2006
-
负责人:Sam R Telford
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依托单位:
Proximal determinants of risk for tularemia outbreaks
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批准号:6804696
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项目类别:
-
资助金额:$23.78万
-
财政年份:2003
-
负责人:Sam R Telford
-
依托单位:
Proximal determinants of risk for tularemia outbreaks
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批准号:6679462
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项目类别:
-
资助金额:$23.78万
-
财政年份:2003
-
负责人:Sam R Telford
-
依托单位:
TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
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批准号:2457850
-
项目类别:
-
资助金额:$22.99万
-
财政年份:1996
-
负责人:Sam R Telford
-
依托单位:
TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
-
批准号:2076114
-
项目类别:
-
资助金额:$22.4万
-
财政年份:1996
-
负责人:Sam R Telford
-
依托单位:
TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
-
批准号:2887096
-
项目类别:
-
资助金额:$25.03万
-
财政年份:1996
-
负责人:Sam R Telford
-
依托单位:
TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
-
批准号:2672635
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项目类别:
-
资助金额:$23.98万
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财政年份:1996
-
负责人:Sam R Telford
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依托单位:
RESERVOIR IMMUNITY IN LYME DISEASE VECTOR COMPETENCE
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批准号:2887024
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项目类别:
-
资助金额:$11.66万
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财政年份:1995
-
负责人:Sam R Telford
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依托单位:
海外基金