NERBL Core 2: BSL-3 Practices

项目概要-核心2 新英格兰地区核心2（生物安全3级实践）的广泛、长期目标 生物安全实验室（NERBL）是为了确保研究或任务，旨在促进研究或 对潜在大流行病原体和其他新出现的感染（PPP/EI）的反应，是安全，有效， 严格地完成。在生物隔离中进行的研究依赖于受过训练的人员， 具备在实验室和动物园安全工作的足够知识。尽管塔夫茨大学 生物安全和环境卫生计划为所有NERBL工作人员提供定期的一般培训，这不是 标准化，大部分项目特定的指导由个人PI或相关人员管理。 因此，NERBL工作人员对实践和程序的了解不均衡， 操作特定技术或在某些生物防护领域工作所需技能的深度 设置.也没有定期的工作人员再培训计划，以保持基本的能力，这影响到 熟悉不经常进行的活动。总之，这些限制限制了 在NERBL中定期进行的范围研究活动。为了弥补这一差距，核心2将重点关注 发展和维持一个在生物防护工作中拥有核心能力的团队， 涵盖一般BSL 3实验室和动物园研究的实践和程序，以及 对于建筑业来说。这种教学将涵盖生物防护管理的基本技能， 应急和事件响应原则，设备安全操作的最佳实践， 执行程序，使用新技术，以及畜牧业和福利， 安全壳具体而言，我们将优化生物安全和生物安保做法和程序， 应急和事件响应/生命安全培训，在NERBL实施最佳实践培训 并协调选择代理程序。虽然核心2的工作人员将领导培训，但所有NERBL工作人员 我们将定期参与这项工作。此外，我们将在Core 2中采用培训培训师的方法， 提高专业知识的深度，扩大改进流程的能力。

PROJECT SUMMARY – CORE 2 The broad, long-range objectives of Core 2 (Biosafety Level 3 Practices ) for the New England Regional Biosafety Laboratory (NERBL) are to ensure that research or tasks directed to promoting research on or responding to pathogens of pandemic potential, and other emerging infections (PPP/EI), are safely, efficiently, and rigorously accomplished. Research conducted in biocontainment relies on trained personnel with adequate knowledge to safely work in both laboratory and vivarium spaces. Although the Tufts institutional biosafety and environmental hygiene programs provide periodic general training to all NERBL staff, this is not standardized and much of the project specific instruction is administered by individual PIs or associated staff. As such, knowledge regarding practices and procedures is uneven across the NERBL staff resulting in lack of depth with respect to skills required for operating specific technologies or working in certain biocontainment settings. There is also no regular plan for staff re-training to maintain basic competencies which impacts familiarity with activities that are not routinely performed. Together, these limitations have constrained the scope research activities routinely undertaken in the NERBL. To address this gap, Core 2 will focus on developing and maintaining a team that possesses core competencies in biocontainment work, spanning the practices and procedures for general BSL3 laboratory and vivarium research as well as for that of building operations. Such instruction will cover essential skills in biocontainment management, principles of emergency and incident response, best practices for safe operation of equipment and performance of procedures, use of newer technologies, as well as animal husbandry and welfare in containment. Specifically, we will optimize biosafety and biosecurity practices and procedures, standardize emergency and incident response/life safety trainings, implement best practices trainings across the NERBL and coordinate the Select Agent program. Although staff from Core 2 will lead the trainings, all NERBL staff will regularly participate in this effort. Additionally, we will employ a train-the-trainer approach within Core 2 to enhance depth of expertise and expand capacities for process improvement.