Dietary protein effects in elderly women: musculoskeletal, renal, cardiovascular and body composition endpoints

膳食蛋白质对老年女性的影响：肌肉骨骼、肾脏、心血管和身体成分终点

• 批准号: nhmrc : 458625
• 负责人: A/Pr Amanda Devine
• 金额: $ 31.94万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dietary-protein-effects-composition-endpoints/94885
• 关键词: Dietary; protein; effects; elderly; women

Fractures and falls of the elderly are major health problems in our community in terms of disability and cost. It is critical to the future health of our aging population to develop non-pharmaceutical interventions to maintain health into old age. Epidemiologic studies have shown that relatively high protein intake is associated with increased bone mineral mass and reduced incidence of osteoporotic fracture in elderly people. Low protein intakes can lead to loss of muscle mass. To date there have been no randomised trials of sufficient duration to examine the effects of increased dietary protein intake on bone and muscle health of the elderly. The aim of this study is to examine the effectiveness of protein supplementation for the prevention of osteoporosis and muscle wasting in elderly women, and the safety of such an intervention through monitoring renal function and risk factors for cardiovascular disease. Two hundred and twenty women will be recruited to this study and be assigned to protein group or placebo group. Women in the protein group will received 250 ml high protein drink (containing 30 g protein) per day and women in the placebo group will receive placebo drink containing the same amount of energy, calcium but no additional protein. Bone structure, muscle mass, body composition, renal function and risk factors for cardiovascular disease will be monitored during the 2 year study period. The results of this randomised, controlled study will clarify the role of protein on bone mass and structure, muscle mass and body composition in the elderly. At the same time, the safety of such intervention on renal and cardiovascular endpoints will also be evaluated. It is envisaged that the results of this study if positive will translate into both immediately applicable intervention strategies that are relevant at a program and an individual level.

老年人的骨折和跌倒，在残疾和成本方面，是我们社会的主要健康问题。发展非药物干预措施以保持老年健康对我国老龄化人口的未来健康至关重要。流行病学研究表明，相对较高的蛋白质摄入与老年人骨矿物质量增加和骨质疏松性骨折发生率降低有关。低蛋白质摄入会导致肌肉量的减少。到目前为止，还没有足够持续时间的随机试验来检验增加膳食蛋白质摄入量对老年人骨骼和肌肉健康的影响。本研究的目的是通过监测肾功能和心血管疾病的危险因素来检验补充蛋白质预防老年妇女骨质疏松症和肌肉萎缩的有效性，以及这种干预的安全性。这项研究将招募220名女性，并将她们分为蛋白质组和安慰剂组。蛋白质组的女性每天喝250毫升高蛋白饮料（含30克蛋白质），安慰剂组的女性每天喝含有相同能量、钙但不含额外蛋白质的安慰剂饮料。在为期2年的研究期间，将监测骨骼结构、肌肉质量、身体组成、肾功能和心血管疾病的危险因素。这项随机对照研究的结果将阐明蛋白质对老年人骨量和结构、肌肉量和身体成分的作用。同时，还将评估这种干预在肾脏和心血管终点的安全性。据设想，如果这项研究的结果是积极的，那么它将转化为与项目和个人水平相关的立即适用的干预策略。