Novel dietary interventions for reducing obesity-associated breast cancer

减少肥胖相关乳腺癌的新型饮食干预措施

基本信息

  • 批准号:
    10544502
  • 负责人:
  • 金额:
    $ 61.66万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-01-01 至 2026-12-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Despite new treatment modalities, the incidence of breast cancer has remained steady in recent years with >250,000 new diagnoses and >40,000 deaths annually in the US. Concurrently, the proportion of US women with overweight or obesity continues to rise, and is approaching 70%. Obesity and metabolic disease (which occurs in lean and obese women) increase breast cancer incidence and worsen patient outcomes in women of all ages. Premenopausal women with obesity are at increased risk of triple negative (TN) breast cancer (lacking any targetable factors). Postmenopausal women with obesity incur more estrogen receptor (ER) positive breast cancer and are more likely to develop resistance to endocrine therapies. While estrogen is clearly an important part of this relationship, two key observations suggest that there may be estrogen-independent mechanisms at play: 1) obesity is accompanied by worse prognosis for estrogen-independent triple negative breast cancer; and 2) anti-estrogen therapies are less effective against ER+ breast tumors in women with obesity. Regardless of tumor subtype and menopausal status, excess weight is associated with poor outcomes for breast cancer patients. Weight loss is known to improve breast cancer outcomes, but most people cannot sustain the standard dietary weight loss strategies and weight regain is common. Intermittent energy restriction (IER) is a novel dietary weight loss strategy that may have more beneficial effects on metabolic health and on breast cancer risk and tumor progression. The work in this proposal will employ preclinical, clinical, and interventional studies, to examine a novel mechanism of obesity-associated tumor progression and the value and feasibility of innovative dietary interventions for eliminating obesity’s adverse effects on breast cancer. We have merged expertise in nutrition, obesity, and medical oncology to: 1) examine a novel role that cancer- associated fibroblasts (CAFs) and the tumor microenvironment (TME) may be playing in obesity-associated tumor progression; 2) investigate if the novel dietary weight loss strategy of IER can eliminate obesity-associated tumor progression; and 3) perform an ORBIT Phase IIa proof-of-concept study examining the ability of an IER- based weight loss intervention to reach meaningful clinical milestones in breast cancer patients afflicted with overweight and obesity and refine the intervention for delivery in a future randomized efficacy trial. If the objectives of this proposal are achieved, we will have: * Advanced our understanding of the obesity – breast cancer relationship, with evidence of a novel role for CAFs and the TME in obesity-associated tumor promotion for TN and ER+ breast cancer; * Established the foundation for IER weight loss trials in breast cancer survivors, with data that will help us adapt these strategies to the unique characteristics and needs of this patient population; and * Identified novel circulating biomarkers of a pro-metastatic TME, which may help identify patients most susceptible to metastatic disease.
项目概要 尽管出现了新的治疗方式,但近年来乳腺癌的发病率仍保持稳定 美国每年新增确诊病例超过 25 万例,死亡病例超过 4 万例。与此同时,美国女性的比例 超重或肥胖的比例持续上升,已接近70%。肥胖和代谢疾病(其中 发生在瘦和肥胖的女性中)会增加乳腺癌的发病率并恶化女性的患者预后 所有年龄段。绝经前肥胖女性患三阴性 (TN) 乳腺癌(缺乏 任何可针对的因素)。绝经后肥胖女性的乳房雌激素受体(ER)阳性率更高 癌症,并且更有可能对内分泌治疗产生耐药性。虽然雌激素显然是一种重要的 作为这种关系的一部分,两个关键观察结果表明,在 发挥:1)肥胖伴随着雌激素非依赖性三阴性乳腺癌的较差预后;和 2) 抗雌激素疗法对肥胖女性的 ER+ 乳腺肿瘤效果较差。不管 肿瘤亚型和绝经状态,体重过重与乳腺癌的不良预后相关 患者。众所周知,减肥可以改善乳腺癌的预后,但大多数人无法维持这个标准 饮食减肥策略和体重反弹是常见的。间歇性能量限制(IER)是一种新颖的饮食方式 减肥策略可能对代谢健康和乳腺癌风险产生更有益的影响 肿瘤进展。该提案中的工作将采用临床前、临床和介入研究,以 研究肥胖相关肿瘤进展的新机制以及创新的价值和可行性 消除肥胖对乳腺癌不利影响的饮食干预。 我们融合了营养、肥胖和肿瘤医学方面的专业知识,以:1)研究癌症的新作用—— 相关成纤维细胞(CAF)和肿瘤微环境(TME)可能在肥胖相关性中发挥作用 肿瘤进展; 2)研究IER的新型饮食减肥策略是否可以消除与肥胖相关的因素 肿瘤进展; 3) 进行 ORBIT IIa 阶段概念验证研究,检查 IER- 基于减肥干预的乳腺癌患者达到有意义的临床里程碑 超重和肥胖,并在未来的随机疗效试验中完善干预措施。 如果该提案的目标得以实现,我们将: * 增进了我们对肥胖与乳腺癌关系的理解,有证据表明肥胖具有新的作用 CAF 和 TME 在 TN 和 ER+ 乳腺癌中与肥胖相关的肿瘤促进作用; * 为乳腺癌幸存者的 IER 减肥试验奠定了基础,数据将帮助我们 使这些策略适应该患者群体的独特特征和需求;和 * 确定了促转移 TME 的新型循环生物标志物,这可能最有助于识别患者 易患转移性疾病。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

VICTORIA A CATENACCI其他文献

VICTORIA A CATENACCI的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('VICTORIA A CATENACCI', 18)}}的其他基金

Training the Next Generation of Innovative and Collaborative Patient-Oriented Researchers to Reduce Obesity and Improve Cardiometabolic Health
培训下一代创新和协作的以患者为中心的研究人员,以减少肥胖并改善心脏代谢健康
  • 批准号:
    10721553
  • 财政年份:
    2023
  • 资助金额:
    $ 61.66万
  • 项目类别:
Novel dietary interventions for reducing obesity-associated breast cancer
减少肥胖相关乳腺癌的新型饮食干预措施
  • 批准号:
    10367368
  • 财政年份:
    2022
  • 资助金额:
    $ 61.66万
  • 项目类别:
Does When You Exercise Matter? A Randomized Trial Comparing the Effect of Morning versus Evening Aerobic Exercise on Weight Loss and Compensatory Behaviors
运动时间重要吗?
  • 批准号:
    10627954
  • 财政年份:
    2021
  • 资助金额:
    $ 61.66万
  • 项目类别:
Does When You Exercise Matter? A Randomized Trial Comparing the Effect of Morning versus Evening Aerobic Exercise on Weight Loss and Compensatory Behaviors
运动时间重要吗?
  • 批准号:
    10296553
  • 财政年份:
    2021
  • 资助金额:
    $ 61.66万
  • 项目类别:
Does When You Exercise Matter? A Randomized Trial Comparing the Effect of Morning versus Evening Aerobic Exercise on Weight Loss and Compensatory Behaviors
运动时间重要吗?
  • 批准号:
    10470288
  • 财政年份:
    2021
  • 资助金额:
    $ 61.66万
  • 项目类别:
Comparison of Weight Loss Induced by Intermittent Fasting Versus Daily Caloric Restriction in Individuals with Obesity: A 1-Year Randomized Trial
肥胖个体间歇性禁食与每日热量限制引起的体重减轻的比较:一年随机试验
  • 批准号:
    9381546
  • 财政年份:
    2017
  • 资助金额:
    $ 61.66万
  • 项目类别:
Comparison of Weight Loss Induced by Intermittent Fasting Versus Daily Caloric Restriction in Individuals with Obesity: A 1-Year Randomized Trial
肥胖个体间歇性禁食与每日热量限制引起的体重减轻的比较:一年随机试验
  • 批准号:
    9981732
  • 财政年份:
    2017
  • 资助金额:
    $ 61.66万
  • 项目类别:
Comparison of Weight Loss Induced by Intermittent Fasting Versus Daily Caloric Restriction in Individuals with Obesity: A 1-Year Randomized Trial
肥胖个体间歇性禁食与每日热量限制引起的体重减轻的比较:一年随机试验
  • 批准号:
    10187552
  • 财政年份:
    2017
  • 资助金额:
    $ 61.66万
  • 项目类别:
Optimal Timing of Exercise Initiation Within a Lifestyle Weight Loss Program
生活方式减肥计划中开始运动的最佳时机
  • 批准号:
    8921190
  • 财政年份:
    2013
  • 资助金额:
    $ 61.66万
  • 项目类别:
Optimal Timing of Exercise Initiation Within a Lifestyle Weight Loss Program
生活方式减肥计划中开始运动的最佳时机
  • 批准号:
    9336877
  • 财政年份:
    2013
  • 资助金额:
    $ 61.66万
  • 项目类别:

相似海外基金

An innovative, AI-driven prehabilitation platform that increases adherence, enhances post-treatment outcomes by at least 50%, and provides cost savings of 95%.
%20创新、%20AI驱动%20康复%20平台%20%20增加%20依从性、%20增强%20治疗后%20结果%20by%20at%20至少%2050%、%20和%20提供%20成本%20节省%20of%2095%
  • 批准号:
    10057526
  • 财政年份:
    2023
  • 资助金额:
    $ 61.66万
  • 项目类别:
    Grant for R&D
Improving Repositioning Adherence in Home Care: Supporting Pressure Injury Care and Prevention
提高家庭护理中的重新定位依从性:支持压力损伤护理和预防
  • 批准号:
    490105
  • 财政年份:
    2023
  • 资助金额:
    $ 61.66万
  • 项目类别:
    Operating Grants
I-Corps: Medication Adherence System
I-Corps:药物依从性系统
  • 批准号:
    2325465
  • 财政年份:
    2023
  • 资助金额:
    $ 61.66万
  • 项目类别:
    Standard Grant
Unintrusive Pediatric Logging Orthotic Adherence Device: UPLOAD
非侵入式儿科记录矫形器粘附装置:上传
  • 批准号:
    10821172
  • 财政年份:
    2023
  • 资助金额:
    $ 61.66万
  • 项目类别:
Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples with Implications for Alzheimer’s Disease Risk
Nuestro Sueno:夫妻干预措施的文化适应,以改善拉丁裔夫妇的 PAP 依从性和睡眠健康,对阿尔茨海默病风险产生影响
  • 批准号:
    10766947
  • 财政年份:
    2023
  • 资助金额:
    $ 61.66万
  • 项目类别:
CO-LEADER: Intervention to Improve Patient-Provider Communication and Medication Adherence among Patients with Systemic Lupus Erythematosus
共同领导者:改善系统性红斑狼疮患者的医患沟通和药物依从性的干预措施
  • 批准号:
    10772887
  • 财政年份:
    2023
  • 资助金额:
    $ 61.66万
  • 项目类别:
Pharmacy-led Transitions of Care Intervention to Address System-Level Barriers and Improve Medication Adherence in Socioeconomically Disadvantaged Populations
药房主导的护理干预转型,以解决系统层面的障碍并提高社会经济弱势群体的药物依从性
  • 批准号:
    10594350
  • 财政年份:
    2023
  • 资助金额:
    $ 61.66万
  • 项目类别:
Antiretroviral therapy adherence and exploratory proteomics in virally suppressed people with HIV and stroke
病毒抑制的艾滋病毒和中风患者的抗逆转录病毒治疗依从性和探索性蛋白质组学
  • 批准号:
    10748465
  • 财政年份:
    2023
  • 资助金额:
    $ 61.66万
  • 项目类别:
Improving medication adherence and disease control for patients with multimorbidity: the role of price transparency tools
提高多病患者的药物依从性和疾病控制:价格透明度工具的作用
  • 批准号:
    10591441
  • 财政年份:
    2023
  • 资助金额:
    $ 61.66万
  • 项目类别:
Development and implementation of peer-facilitated decision-making and referral support to increase uptake and adherence to HIV pre-exposure prophylaxis in African Caribbean and Black communities in Ontario
制定和实施同行协助决策和转介支持,以提高非洲加勒比地区和安大略省黑人社区对艾滋病毒暴露前预防的接受和依从性
  • 批准号:
    491109
  • 财政年份:
    2023
  • 资助金额:
    $ 61.66万
  • 项目类别:
    Fellowship Programs
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了