Environmental and metabolic influences on musculoskeletal and other diseases in a cohort of elderly women

环境和代谢对老年女性群体肌肉骨骼和其他疾病的影响

• 批准号: nhmrc : 303169
• 负责人: A/Pr Amanda Devine
• 金额: $ 56.05万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/environmental-metabolic-influences-elderly-women/81471
• 关键词: Environmental; metabolic; influences; musculoskeletal; other

Osteoporosis is a largely preventable disease yet 1 in 10 Australians have osteoporosis. Every year >64,000 osteoporotic fractures occur, which is one every 8.1 minutes and women are three times as likely to have the disease than men. The Bone and Calcium Research Group at the University of Western Australia, has been monitoring a cohort of elderly women for since 1998. This study is called the Calcium Intake Fracture Outcome Study or CAIFOS. 1,500 women were recruited to study whether a daily calcium supplement for 5 years helps to prevent fractures compared to a diet without a supplement. Each year the study participants are reviewed and asked whether or not they have broken any bones and have other measurements to monitor their bone and cardiovascular health and cognitive function. The subjects will end the treatment phase in 2003 and they will find out the results of the study. More than 93% are interested in being followed for a further 5 years, where they will be contacted every 6 months and asked questions about their general health including information on fracture, hospital visits and changes in medication use. The subjects will have a clinic visits at 2 and 5 years post treatment. With the ongoing collection of adverse event data and metabolic and environmental data from the first phase of the study, we will be able to examine the metabolic and environmental factors that influence musculoskeletal, cardiovascular and mental health. This is important to determine how we can prevent disease to maintain the quality of life and independence in the elderly, a growing segment of the population.

骨质疏松症在很大程度上是一种可以预防的疾病，但十分之一的澳大利亚人患有骨质疏松症。每年发生超过 64,000 起骨质疏松性骨折，每 8.1 分钟就有 1 起，女性患这种疾病的可能性是男性的三倍。西澳大利亚大学的骨骼和钙研究小组自 1998 年以来一直在监测一组老年妇女。这项研究称为钙摄入骨折结果研究或 CAIFOS。招募了 1,500 名女性来研究与不补充钙的饮食相比，连续 5 年每天补充钙是否有助于预防骨折。每年，研究参与者都会接受审查，询问他们是否骨折，并进行其他测量来监测他们的骨骼和心血管健康以及认知功能。受试者将于2003年结束治疗阶段，他们将得知研究结果。超过 93% 的人有兴趣再接受 5 年的跟踪，每 6 个月就会与他们联系一次，询问他们的一般健康状况，包括骨折、医院就诊和药物使用变化的信息。受试者将在治疗后 2 年和 5 年进行临床就诊。随着第一阶段研究不断收集不良事件数据以及代谢和环境数据，我们将能够检查影响肌肉骨骼、心血管和心理健康的代谢和环境因素。这对于确定我们如何预防疾病以维持老年人口这一不断增长的群体的生活质量和独立性非常重要。