Extension of the Calcium Intake Fracture Outcome Study

钙摄入量骨折结果研究的扩展

• 批准号: nhmrc : 254627
• 负责人: A/Pr Amanda Devine
• 金额: $ 18.14万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/extension-calcium-intake-outcome-study/76929
• 关键词: Extension; Calcium; Intake; Fracture; Outcome

Osteoporosis is a largely preventable disease yet 1 in 10 Australians have osteoporosis. Every year >64,000 osteoporotic fractures occur, which is one every 8.1 minutes and women are three times as likely to have the disease than men. The Bone and Calcium Research Group at the University of Western Australia, is studying how to prevent osteoporosis in elderly women. This study is called the Calcium Intake Fracture Outcome Study or CAIFOS. During 1998, 1,500 women were recruited to study whether a daily calcium supplement for 5 years helps to prevent fractures compared to a diet without a supplement. To do this only half of the women were given calcium supplements and the other half were given matched placebo tablets. Each year the study participants are reviewed and asked whether or not they have broken any bones and have other measurements to monitor their bone health and overall health. The subjects are entering their last year of treatment and will finish the study during 2003. At this appointment all subjects will undergo the same series of measurements that they had at the beginning of the study to determine whether or not they have fractured any bones, improved their bone mass and overall health during the treatment stage. The main outcome of the study is to determine whether calcium is useful as a supplement to prevent osteoporotic fracture in elderly women. If this study finds that fewer women fractured in the calcium treated group compared to the non treated group, given that both groups were similar to begin with, we can say that supplementation with calcium prevents fractures. Thus, public health messages about preventing osteoporosis will be able to direct the community to take supplements to prevent a disease that creates pain and disability in later life. The advantage of this study is that it is studying other aspects of these women health, so we can determine whether the calcium is safe to use and improves people's quality of life.

骨质疏松症是一种基本上可以预防的疾病，但十分之一的澳大利亚人患有骨质疏松症。每年发生64，000例骨质疏松性骨折，即每8.1分钟发生一次，女性患这种疾病的可能性是男性的三倍。西澳大利亚大学的骨骼和钙研究小组正在研究如何预防老年妇女的骨质疏松症。这项研究被称为钙摄入量骨折结果研究或CAIFOS。在1998年期间，招募了1,500名妇女，研究与不补充钙的饮食相比，每天补充钙5年是否有助于预防骨折。为了达到这个目的，只有一半的妇女服用了钙补充剂，另一半服用了相应的安慰剂。每年都会对研究参与者进行审查，并询问他们是否骨折，以及是否有其他测量方法来监测他们的骨骼健康和整体健康状况。受试者将进入治疗的最后一年，并将在2003年完成研究。在该预约时，所有受试者将接受与研究开始时相同的一系列测量，以确定他们在治疗阶段是否有骨折、骨量和整体健康状况是否改善。该研究的主要结果是确定钙是否可作为预防老年妇女骨质疏松性骨折的补充剂。如果这项研究发现，与未治疗组相比，钙治疗组中骨折的女性较少，鉴于两组在开始时相似，我们可以说补充钙可以预防骨折。因此，有关预防骨质疏松症的公共卫生信息将能够指导社区服用补充剂，以预防在晚年造成疼痛和残疾的疾病。这项研究的优点是，它正在研究这些妇女健康的其他方面，因此我们可以确定钙是否可以安全使用，并提高人们的生活质量。