Novel dietary interventions for reducing obesity-associated breast cancer

减少肥胖相关乳腺癌的新型饮食干预措施

基本信息

  • 批准号:
    10367368
  • 负责人:
  • 金额:
    $ 60.69万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-01-01 至 2026-12-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Despite new treatment modalities, the incidence of breast cancer has remained steady in recent years with >250,000 new diagnoses and >40,000 deaths annually in the US. Concurrently, the proportion of US women with overweight or obesity continues to rise, and is approaching 70%. Obesity and metabolic disease (which occurs in lean and obese women) increase breast cancer incidence and worsen patient outcomes in women of all ages. Premenopausal women with obesity are at increased risk of triple negative (TN) breast cancer (lacking any targetable factors). Postmenopausal women with obesity incur more estrogen receptor (ER) positive breast cancer and are more likely to develop resistance to endocrine therapies. While estrogen is clearly an important part of this relationship, two key observations suggest that there may be estrogen-independent mechanisms at play: 1) obesity is accompanied by worse prognosis for estrogen-independent triple negative breast cancer; and 2) anti-estrogen therapies are less effective against ER+ breast tumors in women with obesity. Regardless of tumor subtype and menopausal status, excess weight is associated with poor outcomes for breast cancer patients. Weight loss is known to improve breast cancer outcomes, but most people cannot sustain the standard dietary weight loss strategies and weight regain is common. Intermittent energy restriction (IER) is a novel dietary weight loss strategy that may have more beneficial effects on metabolic health and on breast cancer risk and tumor progression. The work in this proposal will employ preclinical, clinical, and interventional studies, to examine a novel mechanism of obesity-associated tumor progression and the value and feasibility of innovative dietary interventions for eliminating obesity’s adverse effects on breast cancer. We have merged expertise in nutrition, obesity, and medical oncology to: 1) examine a novel role that cancer- associated fibroblasts (CAFs) and the tumor microenvironment (TME) may be playing in obesity-associated tumor progression; 2) investigate if the novel dietary weight loss strategy of IER can eliminate obesity-associated tumor progression; and 3) perform an ORBIT Phase IIa proof-of-concept study examining the ability of an IER- based weight loss intervention to reach meaningful clinical milestones in breast cancer patients afflicted with overweight and obesity and refine the intervention for delivery in a future randomized efficacy trial. If the objectives of this proposal are achieved, we will have: * Advanced our understanding of the obesity – breast cancer relationship, with evidence of a novel role for CAFs and the TME in obesity-associated tumor promotion for TN and ER+ breast cancer; * Established the foundation for IER weight loss trials in breast cancer survivors, with data that will help us adapt these strategies to the unique characteristics and needs of this patient population; and * Identified novel circulating biomarkers of a pro-metastatic TME, which may help identify patients most susceptible to metastatic disease.
项目总结

项目成果

期刊论文数量(0)
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VICTORIA A CATENACCI其他文献

VICTORIA A CATENACCI的其他文献

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{{ truncateString('VICTORIA A CATENACCI', 18)}}的其他基金

Training the Next Generation of Innovative and Collaborative Patient-Oriented Researchers to Reduce Obesity and Improve Cardiometabolic Health
培训下一代创新和协作的以患者为中心的研究人员,以减少肥胖并改善心脏代谢健康
  • 批准号:
    10721553
  • 财政年份:
    2023
  • 资助金额:
    $ 60.69万
  • 项目类别:
Novel dietary interventions for reducing obesity-associated breast cancer
减少肥胖相关乳腺癌的新型饮食干预措施
  • 批准号:
    10544502
  • 财政年份:
    2022
  • 资助金额:
    $ 60.69万
  • 项目类别:
Does When You Exercise Matter? A Randomized Trial Comparing the Effect of Morning versus Evening Aerobic Exercise on Weight Loss and Compensatory Behaviors
运动时间重要吗?
  • 批准号:
    10627954
  • 财政年份:
    2021
  • 资助金额:
    $ 60.69万
  • 项目类别:
Does When You Exercise Matter? A Randomized Trial Comparing the Effect of Morning versus Evening Aerobic Exercise on Weight Loss and Compensatory Behaviors
运动时间重要吗?
  • 批准号:
    10296553
  • 财政年份:
    2021
  • 资助金额:
    $ 60.69万
  • 项目类别:
Does When You Exercise Matter? A Randomized Trial Comparing the Effect of Morning versus Evening Aerobic Exercise on Weight Loss and Compensatory Behaviors
运动时间重要吗?
  • 批准号:
    10470288
  • 财政年份:
    2021
  • 资助金额:
    $ 60.69万
  • 项目类别:
Comparison of Weight Loss Induced by Intermittent Fasting Versus Daily Caloric Restriction in Individuals with Obesity: A 1-Year Randomized Trial
肥胖个体间歇性禁食与每日热量限制引起的体重减轻的比较:一年随机试验
  • 批准号:
    9381546
  • 财政年份:
    2017
  • 资助金额:
    $ 60.69万
  • 项目类别:
Comparison of Weight Loss Induced by Intermittent Fasting Versus Daily Caloric Restriction in Individuals with Obesity: A 1-Year Randomized Trial
肥胖个体间歇性禁食与每日热量限制引起的体重减轻的比较:一年随机试验
  • 批准号:
    9981732
  • 财政年份:
    2017
  • 资助金额:
    $ 60.69万
  • 项目类别:
Comparison of Weight Loss Induced by Intermittent Fasting Versus Daily Caloric Restriction in Individuals with Obesity: A 1-Year Randomized Trial
肥胖个体间歇性禁食与每日热量限制引起的体重减轻的比较:一年随机试验
  • 批准号:
    10187552
  • 财政年份:
    2017
  • 资助金额:
    $ 60.69万
  • 项目类别:
Optimal Timing of Exercise Initiation Within a Lifestyle Weight Loss Program
生活方式减肥计划中开始运动的最佳时机
  • 批准号:
    8921190
  • 财政年份:
    2013
  • 资助金额:
    $ 60.69万
  • 项目类别:
Optimal Timing of Exercise Initiation Within a Lifestyle Weight Loss Program
生活方式减肥计划中开始运动的最佳时机
  • 批准号:
    9336877
  • 财政年份:
    2013
  • 资助金额:
    $ 60.69万
  • 项目类别:

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