ANTIOXIDANTS NUTRIENTS AMONG A BRAZILIAN POPULATION

描述(改编自申请者摘要)：流行病学研究 过去几十年进行的研究表明，感染了 人乳头瘤病毒(HPV)是大多数宫颈癌的原因之一。 前瞻性研究表明，感染HPV的女性更有可能 发生宫颈上皮内瘤变(CIN)，而那些患有 持续致癌型HPV感染的风险显著增加 与短暂感染的妇女相比，发生CIN的可能性更大。此外, HPV持续阳性的女性患HPV的可能性似乎是女性的四倍 持续性宫颈病变。 尽管HPV感染是导致宫颈癌的原因之一，但它可能还不够 需要存在其他因素才能使感染进展到 一种严重的宫颈病变。营养状况可能是一个重要的辅助因素 影响HPV持久性和持续性HPV感染的进展 CIN。然而，营养状况和宫颈之间的联系 致癌作用还没有得到充分的测试。 此应用程序的总体目标是确定，使用前瞻性的 收集的HPV和细胞学数据，血清类胡萝卜素与 一组高危研究中生育酚状态与子宫颈癌变的关系 巴西人乳头瘤病毒自然历史队列的参与者(RO1 CA70269)。这 该项目将提供第一个关于血清类胡萝卜素和 生育酚浓度和持续HPV感染风险；它将是 基于敏感和特异的HPV感染类型评估方法 超过12个月，并评估随后5年的进展风险 CIN。这项拟议的研究的独特之处在于，如果关注的是 宫颈癌的发生：HPV感染、HPV持续和进展到 CIN。它是具有成本效益的，利用以前收集的血清样本和 调查问卷数据。这项研究使用了最先进的方法来确定 PV状态和血清类胡萝卜素和生育酚状态。此外，它还 整合了对HPV状态和血清营养素的多种测量 将测量不精确的概率降至最低的浓度 所产生的时间波动将掩盖两者之间的真实联系 营养状况、HPV持久性和CIN风险。这项研究的结果 将有效地加深我们对抗氧化营养素作用的理解 和子宫颈致癌物质。

DESCRIPTION (Adapted from the Applicant's Abstract): Epidemiologic research conducted over the past couple of decades has shown that infection with the human papilloma virus (HPV) is a cause of most cases of cervical cancer. Prospective studies have shown that women infected with HPV are more likely to develop cervical intraepithelial neoplasia (CIN), and that those with persistent oncogenic type HPV infections are at a significantly increased risk of developing CIN compared with women transiently infected. In addition, persistently HPV positive women appear to be four times more likely to have persistent cervical lesions. Although HPV infection is a cause of cervical cancer, it may be an insufficient cause requiring the presence of other factors for the infection to progress to a significant cervical lesion. Nutritional status may be an important cofactor affecting both HPV persistence and progression of persistent HPV infection to CIN. However, the association between nutritional status and cervical carcinogenesis has not been adequately tested. The overall goal of this application is to determine, using prospectively collected HPV and cytology data, the association between serum carotenoid and tocopherol status and cervical carcinogenesis among a cohort of high risk study participants in the Brazilian HPV Natural History Cohort (RO1 CA70269). This project will provide the first prospective analysis of serum carotenoid and tocopherol concentrations and risk for persistent HPV infection; it will be based on sensitive and specific methods for assessing type of HPV infection over a 12 month period, and evaluate subsequent 5 year risk of progression to CIN. This proposed study is unique in that if focuses on early events in cervical carcinogenesis: HPV infection, HPV persistence, and progression to CIN. It is cost-effective, utilizing previously collected serum samples and questionnaire data. The study utilizes state of the art methods for determining both PV status and serum carotenoid and tocopherol status. Furthermore, it incorporates multiple measurements of both HPV status and serum nutrient concentrations minimizing the probability that measurement imprecision resulting from temporal fluctuations will obscure the true association between nutrients status, and HPV persistence and risk of CIN. Results from this study will efficiently further our understanding of the role of antioxidant nutrients and cervical carcinogens.