COGNITIVE THERAPY FOR IBS--OUTCOME, PROCESS & PREDICTION

描述（改编自研究者摘要）：肠易激综合征 (IBS)是一种广泛的慢性下胃肠道疾病 这似乎是标准医疗护理相对难治的。最近的研究 从我们的实验室强烈表明，认知疗法（CT）是高度 短期内有效（临床改善70- 80%）（最多3 治疗后3个月）。当前的应用程序寻求复制和扩展 我们以前的小规模研究，通过进行对照临床试验， CT与自助支持小组作为注意力安慰剂对照和症状 对240例慢性肠易激综合征患者进行监测和随访 患者至少12个月。为了及时完成项目， 第二个网站，布法罗医学院大学，将增加运行一半的 示例.在这一总体项目中，将开展5项研究： (a)研究压力，特别是轻微的压力事件， IBS症状; (b)对照比较了在小样本中进行的简短（10次）CT检查， 组（SG）和（sic）症状监测。后者随后将 处理以增加研究c、d和e的样本量; (c)通过以下方式识别IBS的CT治疗中的变化过程： 在不同的分析层次上，研究 认知变量和GI症状变化; (d)前瞻性1年随访CT和SG对IBS的影响; (e)IBS的CT治疗结果的预测算法， 从参与者的仔细预处理评估中得出的变量;我们 将确定治疗结束和3个月随访的预测方案 以及哪些变量预测症状缓解的维持超过12 月随访。

DESCRIPTION (adapted from investigator's abstract): Irritable Bowel Syndrome (IBS) is a widespread, chronic, disorder of the lower gastrointestinal tract which seems relatively refractory to standard medical care. Recent research from our laboratory strongly suggests that cognitive therapy (CT) is highly effective (70-80 percent clinically improved) in the short-term (out to 3 months post-treatment). The current application seeks to replicate and extend our previous small-scale studies by conducting a controlled clinical trial of CT vs. a self-help support group as an attention placebo control and symptoms monitoring wait list of 240 chronic IBS patients and follow up the treated patients for at least 12 months. To complete the project in a timely fashion a second site, University of Buffalo Medical Scholl, will be added to run half of the sample. Within this overall project 5 studies will be conducted: (a) examination of relations between stress, especially minor stressful events, and IBS symptoms; (b) controlled comparison of brief (10 sessions) CT administered in small groups to (SG) and to (sic) symptom monitoring. The latter will subsequently be treated to increase the sample sizes for studies c, d, and e; (c) identification of the processes of change within the CT treatment of IBS by examining, at various levels of analysis, the relations between changes in cognitive variables and changes in GI symptoms; (d) prospective one-year follow-up of the effect of CT and SG on IBS; (e) prediction algorithm for the results of the CT treatment of IBS from variables derived from the careful pretreatment assessment of participants; we will determine prediction schemes of end of treatment and a 3-month follow-up as well as what variables predict maintenance of symptom relief over the 12 month follow-up.