PROSPECTIVE STUDY OF STRESS AND MOOD IN CHRONIC HEADACHE

描述：为了收集关于以下方面的潜在作用的信息： 应激、情绪和心理状态在病因和加重中的作用 偏头痛（和其他类型的良性头痛[HA]疾病）， 该项目将在六周内收集预期的每日日记数据 六个变量：头痛强度，压力事件的频率， 感知的压力水平，情绪状态，头痛药物消耗， 并在适当的时候，指出月经周期中的两个关键点 未服用口服避孕药的绝经前妇女：排卵时间和 月经开始的时间。 调查人员认为， 这些变量，HA，情绪和压力，是复杂的。 现有研究 本专题未能以前瞻性的方式， 适当的数据分析程序，并未能说明 药物效果。 这个项目将弥补这些缺陷， 为开发更有效的药物指明了方向 慢性良性HA的非药物治疗，尤其是治疗的匹配 给病人。 225例慢性HA患者（75例偏头痛HA， 75例为紧张型HA，75例为合并或混合型偏头痛， 紧张型HA）将监测HA、感知压力和情绪状态4次 每天使用手持计算机（HHC）进行6周。 受试者将获得报酬 为了参与。 受试者还将记录所有服用的药物， 每天发生压力事件的频率，并在适当时， 月经周期中的几个点 虽然重点是偏头痛HA，其他两组正在运行 （张力型HA和混合HA），以帮助隔离因素和关系 与慢性HA相关相反， 本质上 类似的感知压力和情绪评级，以及数据的频率， 压力事件将从50名付费对照志愿者中收集， 患有慢性HA紊乱。 新的、复杂的数据分析程序将使人们能够检查 数据在几个时间基础上：每天4次，每天和每周。

DESCRIPTION: In order to gather information on the potential roles of stress, mood and psychological state in the etiology and exacerbation of migraine headache (and of other types of benign headache [HA] disorders), the project will gather prospective daily diary data over a six-week period on six variables: headache intensity, frequency of stressful events, perceived level of stress, mood states, medication consumed for headache, and, when appropriate, indications of two key points in the menstrual cycle of premenopausal women not on oral contraceptives: time of ovulation and time of onset of menstruation. The investigators believe the interrelations of these variables, HA, mood and stress, are complex. Available research on the topic has failed to examine all three in a prospective fashion using appropriate data analytic procedures and has failed to account for medication effects. This project will remedy these deficits and in so doing potentially point the way for the development of more effective drug non-drug treament of chronic, benign HA, especially a matching of treatment to the patient. Two-hundred and twenty-five patients with chronic HA (75 with migraine HA, 75 with tension-type HA, and 75 with combined or mixed migraine and tension-type HA) will monitor HA, perceived stress and mood states 4 times per day for 6 weeks using hand-held computers (HHCs). Subjects will be paid for participation. Subjects will also record all medications consumed and frequency of stressful events on a daily basis, and as appropriate, key points in their menstrual cycle. Although the focus is on migraine HA, two other groups are being run (tension-type HA and mixed HA) to help isolate factors and relations idiosyncratic to pure migraine as opposed to being related to chronic HA, per se. Similar perceived stress and mood ratings, as well as data on frequency of stressful events will be gathered from 50 paid control volunteers who do not suffer from a chronic HA disorder. New, sophisticated data analytic procedures will enable examination of the data on several temporal bases: 4 times per day, daily and weekly.