COGNITIVE THERAPY FOR IBS--OUTCOME, PROCESS & PREDICTION

描述(摘自研究人员摘要)：肠易激综合征 肠易激综合征(IBS)是一种广泛存在的慢性下胃肠道疾病 与标准的医疗护理相比，这似乎相对难以接受。最新研究 从我们的实验室强烈建议认知疗法(CT)是高度 短期有效(临床改善70%-80%)(提高到3% 治疗后几个月)。当前的应用程序寻求复制和扩展 我们之前的小规模研究是通过进行一项对照临床试验 CT与自助支持组作为注意力安慰剂对照和症状的对比 240例慢性肠易激综合征患者监测等待名单及治疗随访 患者至少12个月。为了及时完成这个项目， 第二个网站，布法罗大学医学院，将增加到运行一半的 样本。在这一总体项目中，将进行5项研究： (A)审查压力，特别是次要压力事件之间的关系， IBS症状； (B)小剂量短程(10次)CT的对照比较 症状监测(SG)组和(SIC)组。后者随后将被 处理以增加研究c、d和e的样本量； (C)通过以下方式确定CT治疗IBS的变化过程 在不同的分析层面上审查下列变化之间的关系 认知变量与胃肠道症状的变化； (D)CT和SG对IBS影响的前瞻性一年随访； (E)肠易激综合征CT治疗结果的预测算法 从参与者仔细的预评估中得出的变量；我们 将确定治疗结束和3个月随访的预测方案 以及哪些变量预测在12年内症状缓解的持续 一个月的随访。

DESCRIPTION (adapted from investigator's abstract): Irritable Bowel Syndrome (IBS) is a widespread, chronic, disorder of the lower gastrointestinal tract which seems relatively refractory to standard medical care. Recent research from our laboratory strongly suggests that cognitive therapy (CT) is highly effective (70-80 percent clinically improved) in the short-term (out to 3 months post-treatment). The current application seeks to replicate and extend our previous small-scale studies by conducting a controlled clinical trial of CT vs. a self-help support group as an attention placebo control and symptoms monitoring wait list of 240 chronic IBS patients and follow up the treated patients for at least 12 months. To complete the project in a timely fashion a second site, University of Buffalo Medical Scholl, will be added to run half of the sample. Within this overall project 5 studies will be conducted: (a) examination of relations between stress, especially minor stressful events, and IBS symptoms; (b) controlled comparison of brief (10 sessions) CT administered in small groups to (SG) and to (sic) symptom monitoring. The latter will subsequently be treated to increase the sample sizes for studies c, d, and e; (c) identification of the processes of change within the CT treatment of IBS by examining, at various levels of analysis, the relations between changes in cognitive variables and changes in GI symptoms; (d) prospective one-year follow-up of the effect of CT and SG on IBS; (e) prediction algorithm for the results of the CT treatment of IBS from variables derived from the careful pretreatment assessment of participants; we will determine prediction schemes of end of treatment and a 3-month follow-up as well as what variables predict maintenance of symptom relief over the 12 month follow-up.