PROSPECTIVE STUDY OF STRESS AND MOOD IN CHRONIC HEADACHE

描述：为了收集关于潜在角色的信息 应激、情绪和心理状态与心力衰竭的关系 偏头痛(和其他类型的良性头痛[HA]疾病)， 该项目将在六周内收集预期的每日日记数据 关于六个变量：头痛强度，压力事件的频率， 感觉到的压力水平，情绪状态，头痛的药物消耗， 并在适当的时候，说明月经周期的两个关键点 未服用口服避孕药的绝经前妇女：排卵时间和 月经开始的时间。调查人员认为这些相互关系 在这些变量中，HA、情绪和压力是复杂的。可利用的研究 这一主题未能以前瞻性的方式研究这三个问题 适当的数据分析程序，并未能说明 药物效应。这个项目将弥补这些缺陷，并通过这样做 有可能为开发更有效的药物指明方向 慢性良性HA的非药物治疗，尤其是配合治疗 给病人的。 225例慢性HA(75例偏头痛HA， 75例为紧张型HA，75例合并或混合偏头痛和 紧张型HA)将监测HA、感知压力和情绪状态4次 每天使用手持计算机(HHC)，连续6周。受试者将被支付费用 以供参与。受试者还将记录所有服用的药物和 每天发生紧张事件的频率，并在适当情况下，关键 在他们的月经周期中。 虽然关注的焦点是偏头痛HA，但另外两个小组正在运行 (张力型HA和混合型HA)帮助隔离因素和关系 纯性偏头痛的特质，而不是慢性HA， 本身就是。 相似的感知压力和情绪评级，以及关于 有压力的活动将从50名付费对照志愿者中收集，这些志愿者没有 患有慢性HA疾病。 新的、复杂的数据分析程序将使检查 在几个时间基础上的数据：每天4次，每天和每周。

DESCRIPTION: In order to gather information on the potential roles of stress, mood and psychological state in the etiology and exacerbation of migraine headache (and of other types of benign headache [HA] disorders), the project will gather prospective daily diary data over a six-week period on six variables: headache intensity, frequency of stressful events, perceived level of stress, mood states, medication consumed for headache, and, when appropriate, indications of two key points in the menstrual cycle of premenopausal women not on oral contraceptives: time of ovulation and time of onset of menstruation. The investigators believe the interrelations of these variables, HA, mood and stress, are complex. Available research on the topic has failed to examine all three in a prospective fashion using appropriate data analytic procedures and has failed to account for medication effects. This project will remedy these deficits and in so doing potentially point the way for the development of more effective drug non-drug treament of chronic, benign HA, especially a matching of treatment to the patient. Two-hundred and twenty-five patients with chronic HA (75 with migraine HA, 75 with tension-type HA, and 75 with combined or mixed migraine and tension-type HA) will monitor HA, perceived stress and mood states 4 times per day for 6 weeks using hand-held computers (HHCs). Subjects will be paid for participation. Subjects will also record all medications consumed and frequency of stressful events on a daily basis, and as appropriate, key points in their menstrual cycle. Although the focus is on migraine HA, two other groups are being run (tension-type HA and mixed HA) to help isolate factors and relations idiosyncratic to pure migraine as opposed to being related to chronic HA, per se. Similar perceived stress and mood ratings, as well as data on frequency of stressful events will be gathered from 50 paid control volunteers who do not suffer from a chronic HA disorder. New, sophisticated data analytic procedures will enable examination of the data on several temporal bases: 4 times per day, daily and weekly.