PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL

十年间核密度的变化

• 批准号: 6199598
• 负责人: BARBARA EDEN KLEIN
• 金额: $ 21.6万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6199598
• 关键词: aging; biomedical automation; cataract; clinical research; computer assisted medical decision making; cornea opacity; densitometry; diagnosis design /evaluation; diagnosis quality /standard; disease /disorder classification; disease /disorder proneness /risk; eye disorder diagnosis; gender difference; human data; image processing; longitudinal human study; pathologic process

DESCRIPTION: (Applicant's Abstract) Nuclear sclerosis, and its clinically important manifestation as nuclear cataract, is a common age-related ocular problem. In Beaver Dam, Wisconsin, nuclear cataract was the most common cataract type to precede lens extraction While older age and female gender are associated with increased risk, other factors have been found and still other, hypothesized to also be associated with risk, some positively and others negatively. Many current epidemiologic studies of nuclear sclerosis use slit lamp photographs to document severity and compare these with photographic standards to assign severity levels. The resultant grades, while in general ordered as to severity, are variable regarding repeat masked gradings by the same and by different graders. Thus, effects of risk or protective factor, which may be small to moderate, may be missed. We have developed a semi-automated scheme for measuring nuclear density, a reflection of nuclear sclerosis, from previously collected photographs. The method reflects current manual grading schemes in ordering severity, but is highly reproducible. We propose to apply these methods to slit lamp photographs taken three times over a ten-year interval in the large cohort participating in the Beaver Dam Eye Study. This will permit quantitation of nuclear sclerosis in a more reliable manner and on a finer scale than with current manual grading. We propose to examine relationships between previously hypothesized risk and protective factors for prevalent severity of nuclear sclerosis at baseline and for its progression, and to estimate the association of nuclear density with measures of visual function. The advantages of developing and testing these procedures in the Beaver Dam Eye Study are that (1) the data are from a free-living, unselected population in which the spectrum nuclear sclerosis is likely to represent that in other similar communities and (2) the photographs are in hand and thus the project is economical. The approach described will be important in clinical trials that are ongoing, others that have been completed, and still others that are planned by the National Eye Institute and other groups in which finding small to moderate affects will be enhanced by more reliable measures of disease.

描述：（申请人的摘要）核硬化，及其临床 重要表现为核性白内障，是一种常见的年龄相关性眼病 问题.在威斯康星州的比弗坝，核性白内障最常见 白内障类型在透镜摘除术之前， 与增加的风险相关，已经发现了其他因素，还有其他因素， 假设也与风险有关，有些是积极的，有些是消极的。 消极的。目前许多核硬化的流行病学研究使用狭缝 灯照片，以记录严重程度，并将其与照片进行比较 标准来分配严重性级别。由此产生的等级，而一般来说， 根据严重程度排序，对于重复设盲分级， 相同的和不同的等级。因此，风险或保护因素的影响， 其可能是小到中等的，可能会被错过。我们已经开发出一种 测量核密度的半自动化方案， 硬化症，从以前收集的照片。该方法反映了当前 手动分级方案在排序的严重性，但高度可重复。我们 我建议将这些方法应用于裂隙灯拍摄的照片， 在参加比弗坝眼的大队列中， Study.这将允许以更可靠的方法定量核硬化。 方式和更精细的规模比目前的手动分级。我们建议 研究先前假设的风险和保护性风险之间的关系。 基线时核硬化的普遍严重程度及其 进展，并估计核密度与措施的关联 视觉功能。开发和测试这些程序的优势 在比弗坝的眼睛研究中，（1）数据来自自由生活， 光谱核硬化症可能导致 代表在其他类似的社区和（2）照片在手 因此该项目是经济的。所描述的方法将是重要的， 正在进行的临床试验，其他已经完成的， 另一些是由国家眼科研究所和其他团体计划的， 通过更可靠的措施， 疾病