PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL
十年间核密度的变化
基本信息
- 批准号:6199598
- 负责人:
- 金额:$ 21.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-08-01 至 2003-07-31
- 项目状态:已结题
- 来源:
- 关键词:aging biomedical automation cataract clinical research computer assisted medical decision making cornea opacity densitometry diagnosis design /evaluation diagnosis quality /standard disease /disorder classification disease /disorder proneness /risk eye disorder diagnosis gender difference human data image processing longitudinal human study pathologic process
项目摘要
DESCRIPTION: (Applicant's Abstract) Nuclear sclerosis, and its clinically
important manifestation as nuclear cataract, is a common age-related ocular
problem. In Beaver Dam, Wisconsin, nuclear cataract was the most common
cataract type to precede lens extraction While older age and female gender are
associated with increased risk, other factors have been found and still other,
hypothesized to also be associated with risk, some positively and others
negatively. Many current epidemiologic studies of nuclear sclerosis use slit
lamp photographs to document severity and compare these with photographic
standards to assign severity levels. The resultant grades, while in general
ordered as to severity, are variable regarding repeat masked gradings by the
same and by different graders. Thus, effects of risk or protective factor,
which may be small to moderate, may be missed. We have developed a
semi-automated scheme for measuring nuclear density, a reflection of nuclear
sclerosis, from previously collected photographs. The method reflects current
manual grading schemes in ordering severity, but is highly reproducible. We
propose to apply these methods to slit lamp photographs taken three times over
a ten-year interval in the large cohort participating in the Beaver Dam Eye
Study. This will permit quantitation of nuclear sclerosis in a more reliable
manner and on a finer scale than with current manual grading. We propose to
examine relationships between previously hypothesized risk and protective
factors for prevalent severity of nuclear sclerosis at baseline and for its
progression, and to estimate the association of nuclear density with measures
of visual function. The advantages of developing and testing these procedures
in the Beaver Dam Eye Study are that (1) the data are from a free-living,
unselected population in which the spectrum nuclear sclerosis is likely to
represent that in other similar communities and (2) the photographs are in hand
and thus the project is economical. The approach described will be important in
clinical trials that are ongoing, others that have been completed, and still
others that are planned by the National Eye Institute and other groups in which
finding small to moderate affects will be enhanced by more reliable measures of
disease.
描述:(申请人摘要)核硬化症及其临床
重要的表现为核性白内障,是一种常见的老年性眼病
有问题。在威斯康星州的海狸大坝,核性白内障是最常见的
白内障类型优先于晶状体摘除,而年龄和女性为
与风险增加相关的其他因素已经被发现,还有其他,
假设也与风险有关,有些是肯定的,有些是
消极的。目前许多核硬化症的流行病学研究都使用SILT
记录严重程度的灯照片,并与照片进行比较
分配严重级别的标准。所产生的职系,虽然一般而言
按严重程度排序,是关于重复掩码评分的变量
相同的,由不同的年级学生。因此,风险或保护因素的影响,
这可能是小到中等,可能会被遗漏。我们已经开发出一种
反映核密度的半自动核密度测量方案
硬化症,来自之前收集的照片。该方法反映了当前
排序严重程度的手动评分方案,但重复性很高。我们
建议将这些方法应用于三次以上拍摄的狭缝灯照片
参加海狸水坝眼的大队列中的十年间隔
学习。这将使核硬化的定量在一个更可靠的
与目前的人工评分相比,评分方式更合理,评分范围更广。我们建议
检查先前假设的风险和保护之间的关系
基线水平核硬化症流行严重程度的因素及其影响因素
进展,并估计核密度与测量的关联
视觉功能。开发和测试这些程序的优势
在海狸水坝眼睛研究中发现:(1)数据来自自由生活,
谱性核硬化症可能发生的未选定人群
在其他类似社区中代表这一点,以及(2)照片在手中
因此,该项目是经济的。所描述的方法将在
正在进行的临床试验,其他已经完成的临床试验,以及
其他由国家眼科研究所和其他组织计划的
发现轻微到中度影响将通过更可靠的衡量标准来增强
疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BARBARA EDEN KLEIN其他文献
BARBARA EDEN KLEIN的其他文献
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{{ truncateString('BARBARA EDEN KLEIN', 18)}}的其他基金
Epidemiology of Retinopathy and other Complications in Long Term Type 1 Diabetes
长期 1 型糖尿病视网膜病变和其他并发症的流行病学
- 批准号:
9045636 - 财政年份:2005
- 资助金额:
$ 21.6万 - 项目类别:
Epidemiology of Retinopathy and other Complications in Long Term Type 1 Diabetes
长期 1 型糖尿病视网膜病变和其他并发症的流行病学
- 批准号:
8294242 - 财政年份:2005
- 资助金额:
$ 21.6万 - 项目类别:
Epidemiology of Retinopathy and other Complications in Long Term Type 1 Diabetes
长期 1 型糖尿病视网膜病变和其他并发症的流行病学
- 批准号:
8461555 - 财政年份:2005
- 资助金额:
$ 21.6万 - 项目类别:
Epidemiology of Retinopathy and other Complications in Long Term Type 1 Diabetes
长期 1 型糖尿病视网膜病变和其他并发症的流行病学
- 批准号:
8631087 - 财政年份:2005
- 资助金额:
$ 21.6万 - 项目类别:
Family Clustering of Incidence & Progression of Cataract
发病率的家庭聚集性
- 批准号:
6697249 - 财政年份:2001
- 资助金额:
$ 21.6万 - 项目类别:
Family Clustering of Incidence & Progression of Cataract
发病率的家庭聚集性
- 批准号:
6322703 - 财政年份:2001
- 资助金额:
$ 21.6万 - 项目类别:
PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL
十年间核密度的变化
- 批准号:
6524975 - 财政年份:2000
- 资助金额:
$ 21.6万 - 项目类别:
PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL
十年间核密度的变化
- 批准号:
6446369 - 财政年份:2000
- 资助金额:
$ 21.6万 - 项目类别: