Family Clustering of Incidence & Progression of Cataract

描述：（申请人的摘要）本提案描述了一种基于人口的 队列研究，旨在描述年龄相关的家庭聚集性 白内障、视功能、眼内压和全身特征 人口居住在比弗 达姆，威斯康星州。受试者在第一次检查时年龄为43-86岁， 1988- 1990年制定了面谈、检查、验血和 在第一次检查和第二次检查时进行眼部摄影和分级 1993- 1995年和1998-2000年进行了后续检查。基线人群内 （n = 4，926）我们确定了587个兄弟姐妹组，由1，403人组成。 研究参与者在三次检查中进行了标准化检查 自行车.已收集有关白内障、其他年龄相关 眼睛疾病，医疗条件，药物使用;血压，身高和 已经测量了体重，以及几个血液参数基线。在 随访，其他虚弱的测量（通过手握力估计， 缓慢定时步行，减少呼气峰流量）已被添加到 议定书死亡率已被仔细监测，死亡证明 已获得信息。我们将研究白内障的变化， 以及其他眼部和全身因素，在家庭中聚集， 白内障进展越快的家庭， 全身发病率、虚弱和死亡率。 在研究过程中，我们进行了后续访谈， 我们已经意识到大约400伯父，父母和堂兄弟关系， 社区我们将完成我们的家庭血统信息之前， 从这份赠款开始。我们提出了广泛的家庭聚集分析， 广义估计方程，并在适当时，混合和 分离分析这笔赠款将利用以前收集的数据 由国家眼科研究所资助。我们目前没有资金 支持拟议的分析。我们相信这个项目提供了 在一个大家庭中检验重要的假设， 基于人口的框架。

DESCRIPTION: (Applicant's Abstract) This proposal describes a population-based cohort study aimed at describing the family aggregation of age-related cataracts, visual function, intra-ocular pressure, and systemic characteristics of aging, cross-sectionally and longitudinally The population resides in Beaver Dam, Wisconsin. Subjects were 43-86 years of age at the first examination in 1988-90 Standardized protocols for interviews, examination, blood tests, and ocular photography and grading were performed at first examination and two follow-up examinations in 1993-95 and 1998-2000. Within the baseline population (n equals 4,926) we identified 587 sibling groups composed of 1,403 persons. Study participants have had standardized examinations at the three examination cycles. Information has been collected regarding cataract, other age-related eye diseases, medical conditions, medication usage; blood pressures, height and weight have been measured, as have several blood parameters baseline. At the follow-up visits, other measures of frailty (estimated by hand grip strength, slower timed walk, decrease peak expiratory flow) have been added to the protocol. Mortality has been carefully monitored and death certificate information has been obtained. We will investigate whether changes in cataract, as well as other ocular and systemic factors, aggregate in families and whether families that display greater progression of cataracts are at greater risk of systemic morbidity, frailty and mortali1y. During the course of the study, we have had follow-up interviews during which we have become aware of about 400 avuncular, parent and cousin relations in the community. We will complete our family pedigree information prior to the beginning of this grant. We propose extensive family aggregation analyses using generalized estimating equations and, when appropriate, commingling and segregation analyses. This grant will capitalize on data previously collected from grants funded by the National Eye Institute. We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework.