PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL

十年间核密度的变化

• 批准号: 6524975
• 负责人: BARBARA EDEN KLEIN
• 金额: $ 16.32万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6524975
• 关键词: aging; biomedical automation; cataract; clinical research; computer assisted medical decision making; cornea opacity; densitometry; diagnosis design /evaluation; diagnosis quality /standard; disease /disorder classification; disease /disorder proneness /risk; eye disorder diagnosis; gender difference; human data; image processing; longitudinal human study; pathologic process

DESCRIPTION: (Applicant's Abstract) Nuclear sclerosis, and its clinically important manifestation as nuclear cataract, is a common age-related ocular problem. In Beaver Dam, Wisconsin, nuclear cataract was the most common cataract type to precede lens extraction While older age and female gender are associated with increased risk, other factors have been found and still other, hypothesized to also be associated with risk, some positively and others negatively. Many current epidemiologic studies of nuclear sclerosis use slit lamp photographs to document severity and compare these with photographic standards to assign severity levels. The resultant grades, while in general ordered as to severity, are variable regarding repeat masked gradings by the same and by different graders. Thus, effects of risk or protective factor, which may be small to moderate, may be missed. We have developed a semi-automated scheme for measuring nuclear density, a reflection of nuclear sclerosis, from previously collected photographs. The method reflects current manual grading schemes in ordering severity, but is highly reproducible. We propose to apply these methods to slit lamp photographs taken three times over a ten-year interval in the large cohort participating in the Beaver Dam Eye Study. This will permit quantitation of nuclear sclerosis in a more reliable manner and on a finer scale than with current manual grading. We propose to examine relationships between previously hypothesized risk and protective factors for prevalent severity of nuclear sclerosis at baseline and for its progression, and to estimate the association of nuclear density with measures of visual function. The advantages of developing and testing these procedures in the Beaver Dam Eye Study are that (1) the data are from a free-living, unselected population in which the spectrum nuclear sclerosis is likely to represent that in other similar communities and (2) the photographs are in hand and thus the project is economical. The approach described will be important in clinical trials that are ongoing, others that have been completed, and still others that are planned by the National Eye Institute and other groups in which finding small to moderate affects will be enhanced by more reliable measures of disease.

描述：（申请人的摘要）核硬化及其临床 核性白内障的重要表现，是一种常见的与年龄相关的眼病 问题。在威斯康星州海狸坝，核性白内障是最常见的 摘除晶状体前的白内障类型 虽然年龄较大和女性性别 与风险增加相关，还发现了其他因素，还有其他因素， 假设也与风险相关，有些是积极的，有些是积极的 消极地。目前许多核硬化的流行病学研究都使用狭缝 灯照片记录严重程度并将其与照片进行比较 分配严重性级别的标准。所得到的成绩，虽然在一般情况下 根据严重程度排序，关于重复屏蔽分级是可变的 相同且由不同的评分者进行。因此，风险或保护因素的影响， 可能是小到中等，可能会被错过。我们开发了一个 测量核密度的半自动方案，反映核 硬化症，来自以前收集的照片。该方法反映了当前 手动分级方案按严重程度排序，但具有高度可重复性。我们 建议将这些方法应用于裂隙灯拍摄三遍以上的照片 参与 Beaver Dam Eye 的大型队列中的十年间隔 学习。这将允许以更可靠的方式对核硬化进行定量 比当前的手动分级更精细的方式。我们建议 检查先前假设的风险和保护性之间的关系 基线时核硬化普遍严重程度的因素及其影响 进展，并估计核密度与测量的关联 的视觉功能。开发和测试这些程序的优点 海狸坝眼睛研究中的内容是（1）数据来自自由生活的、 未选择的人群，其中谱核硬化可能 代表其他类似社区，并且 (2) 照片已在手 因此该项目是经济的。所描述的方法在以下方面很重要 正在进行的临床试验，其他已经完成的临床试验，以及仍在进行中的临床试验 由国家眼科研究所和其他团体计划的其他项目 通过更可靠的措施可以加强对小到中度影响的发现 疾病。