Family Clustering of Incidence & Progression of Cataract

发病率的家庭聚集性

• 批准号: 6322703
• 负责人: BARBARA EDEN KLEIN
• 金额: $ 14.55万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6322703
• 关键词: aging; biotechnology; cataract; clinical research; computer data analysis; eye disorder; family genetics; genetic susceptibility; human data; human morbidity; human mortality; interview; intraocular pressure; linkage mapping; longitudinal human study; pathologic process

DESCRIPTION: (Applicant's Abstract) This proposal describes a population-based cohort study aimed at describing the family aggregation of age-related cataracts, visual function, intra-ocular pressure, and systemic characteristics of aging, cross-sectionally and longitudinally The population resides in Beaver Dam, Wisconsin. Subjects were 43-86 years of age at the first examination in 1988-90 Standardized protocols for interviews, examination, blood tests, and ocular photography and grading were performed at first examination and two follow-up examinations in 1993-95 and 1998-2000. Within the baseline population (n equals 4,926) we identified 587 sibling groups composed of 1,403 persons. Study participants have had standardized examinations at the three examination cycles. Information has been collected regarding cataract, other age-related eye diseases, medical conditions, medication usage; blood pressures, height and weight have been measured, as have several blood parameters baseline. At the follow-up visits, other measures of frailty (estimated by hand grip strength, slower timed walk, decrease peak expiratory flow) have been added to the protocol. Mortality has been carefully monitored and death certificate information has been obtained. We will investigate whether changes in cataract, as well as other ocular and systemic factors, aggregate in families and whether families that display greater progression of cataracts are at greater risk of systemic morbidity, frailty and mortali1y. During the course of the study, we have had follow-up interviews during which we have become aware of about 400 avuncular, parent and cousin relations in the community. We will complete our family pedigree information prior to the beginning of this grant. We propose extensive family aggregation analyses using generalized estimating equations and, when appropriate, commingling and segregation analyses. This grant will capitalize on data previously collected from grants funded by the National Eye Institute. We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework.

描述：(申请人摘要)这项建议描述了一项以人群为基础的队列研究，旨在描述与年龄相关的家庭聚集 白内障、视功能、眼压和全身特征 从横向和纵向来看，种群居住在海狸 威斯康星州的丹姆。第一次检查时，受试者年龄在43-86岁之间。 1988-90年代标准化的面谈、检查、血液测试和 在第一次检查和两次检查时进行眼部照相和分级 一九九三至九五年及一九九八至二零零零年的跟进考试。在基线人口范围内 (n等于4926)我们确定了由1,403人组成的587个兄弟姐妹团体。 研究参与者在三次考试中都进行了标准化考试 循环。已收集关于白内障、其他与年龄有关的眼病、医疗条件、用药情况、血压、身高和 已经测量了体重，也测量了几个血液参数基线。在 随访，其他脆弱程度的测量(通过握手力量估计， 更慢的定时行走，降低最大呼气流量)已经添加到 协议。已仔细监测死亡情况并出具死亡证明 已经得到了信息。我们将调查白内障的变化， 以及其他眼部和全身因素，在家庭中的总和以及是否 表现为白内障进展较快的家庭患白内障的风险更大 全身性发病率、脆弱性和致命性。 在研究过程中，我们进行了后续访谈，在此期间， 我们已经了解到在世界上大约有400个伯父、父母和表亲 社区。在此之前，我们将完成我们的家谱信息 这笔赠款的开始。我们提出了广泛的家庭聚集分析，使用 广义估计方程，并在适当的情况下，混合和 偏析分析。这笔赠款将利用之前收集的数据 来自国家眼科研究所资助的赠款。我们目前没有资金来 支持拟议的分析。我们相信这个项目提供了一种可能性 在一大群家庭中检验重要的假设 基于人口的框架。