HOMEOSTATIC CONTROL OF AMNIOTIC FLUID VOLUME

羊水量的稳态控制

• 批准号: 6194744
• 负责人: JOB J. FABER
• 金额: $ 30.58万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6194744
• 关键词: albumins; amniotic fluid; body fluid osmolarity; electrolytes; embryo /fetus; fluid flow; homeostasis; lung; osmotic pressure; sheep; swallowing; urine; uterus

DESCRIPTION: (Adapted from the Investigator's Abstract) Experiments will be performed on fetal sheep of known gestational ages. Indwelling fetal catheters, flow sensors and amniotic and allantoic fluid catheters will be placed during sterile surgeries under general anesthesia. Hypotheses to be tested include: (l) Urine production, although variable, detracts from, rather than contributes to the control of amniotic fluid volume. (2) Neither lung fluid production, nor drinking of amniotic fluid are necessary for an adequate homeostatic response to abnormal production of amniotic fluid. (3) Fetal swallowing may contribute to amniotic fluid volume regulation even if not necessary in sheep. (4) Reabsorption of amniotic fluid is largely insensitive to electrolyte load. (5) Neither the crystalloid osmotic gradient nor the oncotic gradient between amniotic fluid and fetal plasma are involved in volume regulation. (6) The quantity that is being regulated is amniotic fluid volume, rather than intrauterine volume. (7) The absorptive mechanism permits passage of large quantities of macromolecules, such as plasma albumin, even in the absence of drinking.

描述：（改编自研究者摘要）实验将 在已知胎龄的羊胎上进行。留置胎儿导管， 将放置流量传感器和羊水及尿囊液导管， 全身麻醉下的无菌手术待检验的假设包括： (l)尿的产生，虽然可变，减损，而不是贡献 控制羊水量。(2)既没有肺积液，也没有 羊水的饮用是必要的， 与羊水异常有关(3)胎儿吞咽可能会导致 羊水量调节，即使在绵羊中不需要。（四） 羊水的重吸收对电解质负荷很不敏感。（五） 无论是晶体渗透梯度，也不是之间的oncogene梯度 羊水和胎儿血浆参与容量调节。(6)的 被调节的量是羊水量，而不是 子宫内容积。(7)吸收机制允许通过大的 大量的大分子，如血浆白蛋白，即使在没有 喝酒