HOMEOSTATIC CONTROL OF AMNIOTIC FLUID VOLUME

羊水量的稳态控制

• 批准号: 6521150
• 负责人: JOB J. FABER
• 金额: $ 30.58万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6521150
• 关键词: albumins; amniotic fluid; body fluid osmolarity; electrolytes; embryo /fetus; fluid flow; homeostasis; lung; osmotic pressure; sheep; swallowing; urine; uterus

DESCRIPTION: (Adapted from the Investigator's Abstract) Experiments will be performed on fetal sheep of known gestational ages. Indwelling fetal catheters, flow sensors and amniotic and allantoic fluid catheters will be placed during sterile surgeries under general anesthesia. Hypotheses to be tested include: (l) Urine production, although variable, detracts from, rather than contributes to the control of amniotic fluid volume. (2) Neither lung fluid production, nor drinking of amniotic fluid are necessary for an adequate homeostatic response to abnormal production of amniotic fluid. (3) Fetal swallowing may contribute to amniotic fluid volume regulation even if not necessary in sheep. (4) Reabsorption of amniotic fluid is largely insensitive to electrolyte load. (5) Neither the crystalloid osmotic gradient nor the oncotic gradient between amniotic fluid and fetal plasma are involved in volume regulation. (6) The quantity that is being regulated is amniotic fluid volume, rather than intrauterine volume. (7) The absorptive mechanism permits passage of large quantities of macromolecules, such as plasma albumin, even in the absence of drinking.

描述：(改编自《调查者摘要》)实验将 在已知胎龄的羊胎儿身上进行实验。留置胎儿导管， 期间将放置流量传感器以及羊水和尿囊液导管 全身麻醉下的无菌手术。有待检验的假设包括： (L)尿量虽然是可变的，但它会减损而不是贡献 以控制羊水量。(2)既不产生肺液，也不产生肺液 喝羊水是充分的体内平衡反应所必需的 导致羊水产生异常。(3)胎儿吞咽可能对胎儿的健康有影响 对羊水量进行调节，即使对绵羊来说不是必要的。(4) 羊水重吸收在很大程度上不受电解质负荷的影响。(5) 既不是晶体渗透梯度，也不是 羊水和胎儿血浆参与容量调节。(6) 被调节的数量是羊水量，而不是 宫内量。(7)吸收机构允许大型 大分子的数量，如血浆白蛋白，即使在没有 喝酒。