HOMEOSTATIC CONTROL OF AMNIOTIC FLUID VOLUME

羊水量的稳态控制

• 批准号: 6388059
• 负责人: JOB J. FABER
• 金额: $ 30.58万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6388059
• 关键词: albumins; amniotic fluid; body fluid osmolarity; electrolytes; embryo /fetus; fluid flow; homeostasis; lung; osmotic pressure; sheep; swallowing; urine; uterus

DESCRIPTION: (Adapted from the Investigator's Abstract) Experiments will be performed on fetal sheep of known gestational ages. Indwelling fetal catheters, flow sensors and amniotic and allantoic fluid catheters will be placed during sterile surgeries under general anesthesia. Hypotheses to be tested include: (l) Urine production, although variable, detracts from, rather than contributes to the control of amniotic fluid volume. (2) Neither lung fluid production, nor drinking of amniotic fluid are necessary for an adequate homeostatic response to abnormal production of amniotic fluid. (3) Fetal swallowing may contribute to amniotic fluid volume regulation even if not necessary in sheep. (4) Reabsorption of amniotic fluid is largely insensitive to electrolyte load. (5) Neither the crystalloid osmotic gradient nor the oncotic gradient between amniotic fluid and fetal plasma are involved in volume regulation. (6) The quantity that is being regulated is amniotic fluid volume, rather than intrauterine volume. (7) The absorptive mechanism permits passage of large quantities of macromolecules, such as plasma albumin, even in the absence of drinking.

描述：（改编自研究者的摘要）实验将 对已知胎龄的胎羊进行。留置胎儿导尿管， 流量传感器以及羊水和尿囊液导管将在手术期间放置 全身麻醉下的无菌手术。需要检验的假设包括： (l) 尿液产生量虽然存在差异，但会减少而非促进 以控制羊水量。 (2) 既不产生肺液，也不产生 饮用羊水对于充分的稳态反应是必要的 羊水异常产生。 (3)胎儿吞咽可能有助于 羊水量调节，即使对于绵羊来说不需要。 (4) 羊水的重吸收很大程度上对电解质负荷不敏感。 (5) 晶体渗透梯度和胶体渗透压梯度均不 羊水和胎儿血浆参与容量调节。 (6) 的 所调节的量是羊水量，而不是 子宫内容量。 (7) 吸收机制允许大的物质通过 大量的大分子，例如血浆白蛋白，即使没有 喝。