INTRAVASCULAR MRI--TOWARD CLINICAL INTERVENTIONS

近年来，我们开发了新的血管内MRI（IVMRI）探头， 用于动物模型的导丝和导管的形式。我们有 我还开发了IVMRI技术，使采集高分辨率 血管壁的横截面图像，以及跟踪技术 用于导管的实时可视化。我们相信，使用这些 技术，可以获得有价值的信息，用于诊断和 治疗人类的动脉粥样硬化或其他血管疾病。在这 建议，我们将测试我们的IVMRI技术（）是一个假设， 低风险方法，以及（B）可用于可视化 介入技术，即球囊血管成形术和支架置入术 程序.具体而言，我们将（1）完善和调整现有的IVMRI 导管和导丝形式的探头，适用于 在人类患者中使用，以及（2）评价这些器械在 通过计算/测量 血管内MRI器械的存在导致的额外发热 并评估任何潜在的组织损伤我们还将（3）评估 目前可用的灌注MR成像和非侵入性MR 血管造影（MR）技术可以与IVMRI技术结合， 进行血管内MR透视（IVMRF）引导的介入 手术，即在动物中的球囊血管成形术和支架放置 模型在项目的最后阶段，我们计划获得足够的数据， 申请IRB批准这些技术的研究性使用， 人类病人

In recent years, we have developed new intravascular MRI (IVMRI) probes in the form of guidewires and catheters for use in animal models. We have also developed IVMRI techniques that enable acquisition of high resolution cross-sectional images of the vessel wall, as well as tracking techniques for real-time visualization of the catheters. We believe that using these techniques, valuable information can be obtained for the diagnosis and treatment of atherosclerosis of other vessel diseases in humans. In this proposal, we will test the hypotheses that our IVMRI technique () is a low-risk method and (b) can be used for the visualization of interventional techniques, namely balloon angioplasty and stent placement procedures. Specifically, we will (1) refine and adapt our existing IVMRI probes in the form of catheters and guidewires that will be suitable for use in human patients, and (2) evaluate the safety of these devices in accord with FDA-established guidelines by calculating/measuring the additional heating caused by the presence of the intravascular MRI devices and assessing any potential for tissue damage. We will also (3) evaluate whether currently available perfusion MR imaging and non-invasive MR angiography (MR) techniques can be combined with IVMRI techniques to perform intravascular MR fluoroscopy (IVMRF)-guided interventional procedures, namely, balloon angioplasty and stent placement in animal models. In the final phase of the project, we plan to have enough data to apply for IRB approval for investigational use of these techniques in human patients.