INTRAVASCULAR MAGNETIC RESONANCE TECHNIQUES

血管内磁共振技术

• 批准号: 2910637
• 负责人: ERGIN ATALAR
• 金额: $ 11.42万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2910637
• 关键词: angiography; atherosclerotic plaque; bioimaging /biomedical imaging; biomedical equipment development; cholesterol; dogs; fluoroscopy; image enhancement; laboratory rabbit; magnetic resonance imaging; phantom model

DESCRIPTION (Adapted from Applicant's Abstract): Early diagnosis and monitoring of the progression and regression of atherosclerosis have a crucial importance in the fight against the world's number one fatal heart disease. Magnetic resonance imaging and spectroscopy methods provide valuable information about the morphology and chemical composition of atherosclerotic plaques but suffer from low signal-to-noise ratio and low image resolution. We propose to develop a new intravascular magnetic resonance imaging method that will involve using an MR probe on the tip of a catheter. This will allow more complete characterization of atherosclerotic plaques as well as providing a novel method of monitoring interventional therapy that is not currently possible. The specific aims of this project include the development of a novel real-time MR fluoroscopy technique (5 frames/sec) for 3-D visualization of a catheter probe, and the development of novel encoding techniques to achieve near-microscopic resolution imaging (100 microns) and highly localized spectroscopy. The applicants proposed to validate these techniques on phantoms, dogs and on a high cholesterol-fed atherosclerotic rabbit model. The development of intravascular magnetic resonance techniques will lead to an innovative, practical system that will be used routinely for the diagnosis of atherosclerosis as well as for monitoring various interventional techniques such as laser therapy.

描述（改编自申请人的摘要）：早期诊断和 监测动脉粥样硬化的进展和消退， 在与世界头号致命心脏的斗争中至关重要 疾病 磁共振成像和光谱学方法提供了 有关的形态和化学成分的宝贵信息， 动脉粥样硬化斑块，但患有低信噪比和低 图像分辨率 我们建议开发一种新的血管内磁 一种共振成像方法，将涉及使用MR探头的尖端上， 导尿管 这将使动脉粥样硬化的特征更加完整。 斑块以及提供一种新的方法，监测介入 这是目前不可能的治疗方法。 该项目的具体目标 包括开发一种新型实时MR荧光透视技术（5 帧/秒），用于导管探头的3-D可视化，以及开发 新的编码技术，以实现近微观分辨率成像 (100微米）和高度局部化的光谱学。 申请人建议， 验证这些技术对幻影，狗和高胆固醇喂养 动脉粥样硬化家兔模型。 血管内磁共振成像的发展 共振技术将导致一个创新的，实用的系统， 常规用于动脉粥样硬化的诊断以及 监测各种介入技术，如激光治疗。