INTRAVASCULAR MRI--TOWARD CLINICAL INTERVENTIONS

近年来，我们开发了新的血管内磁共振(IVMRI)探针 动物模型中使用的导丝和导管的形式。我们有 还开发了IVMRI技术，使获得高分辨率成为可能 血管壁的横断面图像以及跟踪技术 用于导管的实时可视化。我们相信，使用这些 技术，可以获得有价值的信息用于诊断和 人类其他血管疾病的动脉粥样硬化的治疗。在这 提案，我们将测试我们的IVMRI技术()是一种 低风险方法和(B)可用于可视化 介入技术，即球囊血管成形术和支架置入术 程序。具体地说，我们将(1)改进和调整现有的IVMRI 导管和导丝形式的探头将适用于 在人类患者中使用，以及(2)评估这些设备的安全性 通过计算/测量符合FDA制定的指南 血管内核磁共振设备的存在引起的额外加热 并评估是否有可能对组织造成损害。我们还将(3)进行评估 目前可用的磁共振灌注成像和无创性磁共振 血管成像(MR)技术可以与IVMRI技术相结合 进行血管内磁共振透视(IVMRF)引导的介入治疗 动物的球囊血管成形术和支架置入术 模特们。在项目的最后阶段，我们计划有足够的数据来 申请IRB批准将这些技术用于 人类病人。

In recent years, we have developed new intravascular MRI (IVMRI) probes in the form of guidewires and catheters for use in animal models. We have also developed IVMRI techniques that enable acquisition of high resolution cross-sectional images of the vessel wall, as well as tracking techniques for real-time visualization of the catheters. We believe that using these techniques, valuable information can be obtained for the diagnosis and treatment of atherosclerosis of other vessel diseases in humans. In this proposal, we will test the hypotheses that our IVMRI technique () is a low-risk method and (b) can be used for the visualization of interventional techniques, namely balloon angioplasty and stent placement procedures. Specifically, we will (1) refine and adapt our existing IVMRI probes in the form of catheters and guidewires that will be suitable for use in human patients, and (2) evaluate the safety of these devices in accord with FDA-established guidelines by calculating/measuring the additional heating caused by the presence of the intravascular MRI devices and assessing any potential for tissue damage. We will also (3) evaluate whether currently available perfusion MR imaging and non-invasive MR angiography (MR) techniques can be combined with IVMRI techniques to perform intravascular MR fluoroscopy (IVMRF)-guided interventional procedures, namely, balloon angioplasty and stent placement in animal models. In the final phase of the project, we plan to have enough data to apply for IRB approval for investigational use of these techniques in human patients.