MR-Guided Coronary Balloon Angioplasty

描述(由申请人提供)：在本竞争续展中 应用，我们计划继续专注于磁共振的发展 用于治疗血管疾病的成像设备和方法。传统型 介入性操作，如球囊血管成形术或血管内支架 放置，主要由x射线透视和造影剂注射引导 勾勒出血管管腔，但此方法不提供有关 血管壁或其病理改变。血管内磁共振成像(IVMRI)提供了几种 与其他成像技术相比具有显著的优势，因为它可以提供 超高分辨率，高对比度，正常和疾病的清晰度 血管，这对于表征动脉粥样硬化是很重要的。我们 开发了微型、长长、可弯曲的导管线圈和无环导管 用于高分辨率血管IVMRI的天线。使用这些探头，我们 成功获取了动脉的在体超高分辨率图像 墙。我们的体外研究表明，使用这种方法，有可能 鉴定人体动脉的三个形态层次并表征 动脉粥样硬化斑块。在这项研究中，我们将检验这一假设 高位MR引导下冠状动脉球囊成形术 精确度高，速度快。为了能够检验这一假设，我们计划 开发性能最好的血管内磁共振探头，并修改硬件和 现有磁共振扫描仪的软件，使成像参数能够在 在血管介入治疗期间，直接由干预者进入扫描室。 此外，我们将开发一种实时投影磁共振血管成像技术， 通过直接向血管内注射造影剂来实现血管成像 动脉。我们将对整个系统的精度和速度进行测试 人工狭窄犬模型。我们相信用这些小说 方法和设备将开辟一条新的途径，以准确、精确和 无辐射冠状动脉介入治疗。

DESCRIPTION (Provided by Applicant): In this competing continuation application, we plan to remain focused on the development of magnetic resonance imaging devices and methods for treatment of vascular diseases. Conventional interventional procedures, such as balloon angioplasty or intravascular stent placement, are primarily guided by x-ray fluoroscopy with contrast injections outlining the vascular lumen, but this method provides no information about the vessel wall or its pathology. Intravascular MRI (IVMRI) offers several significant advantages over other imaging techniques, in that it can provide ultra-high resolution with high contrast definition of normal and diseased vessels, which is important for the characterization of atherosclerosis. We have developed miniature, long, flexible catheter coils and loopless catheter antennae for high resolution IVMRI of the blood vessels. Using these probes, we successfully acquired in vivo ultra-high resolution images of the arterial wall. Our in vitro studies demonstrated that, using this method, it is possible to identify the three morphological layers of human arteries and characterize atherosclerotic plaques. In this study, we will test the hypothesis that MR-guided coronary artery balloon angioplasty can be carried out with high accuracy and at high speed. To be able to test this hypothesis, we plan to develop the best-performing intravascular MR probes and modify the hardware and software of existing MR scanners to enable control of the imaging parameters in the scanner room directly by interventionalists during a vascular intervention. Moreover, we will develop a real-time projection MR angiography technique that enables imaging of the blood vessels by contrast injection directly into the arteries. We will test the accuracy and the speed of the overall system on a dog model with an artificial stenosis. We believe that using these novel methods and devices will open up a new avenue for accurate, precise and radiation-free coronary interventions.