INTRAVASCULAR MRI--TOWARD CLINICAL INTERVENTIONS

血管内 MRI——走向临床干预

• 批准号: 6490632
• 负责人: ERGIN ATALAR
• 金额: $ 25.7万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6490632
• 关键词: angiography; atherosclerosis; bioimaging /biomedical imaging; blood vessel prosthesis; diagnosis design /evaluation; dogs; fluoroscopy; intraluminal angioplasty; laboratory rabbit; magnetic resonance imaging; technology /technique development

In recent years, we have developed new intravascular MRI (IVMRI) probes in the form of guidewires and catheters for use in animal models. We have also developed IVMRI techniques that enable acquisition of high resolution cross-sectional images of the vessel wall, as well as tracking techniques for real-time visualization of the catheters. We believe that using these techniques, valuable information can be obtained for the diagnosis and treatment of atherosclerosis of other vessel diseases in humans. In this proposal, we will test the hypotheses that our IVMRI technique () is a low-risk method and (b) can be used for the visualization of interventional techniques, namely balloon angioplasty and stent placement procedures. Specifically, we will (1) refine and adapt our existing IVMRI probes in the form of catheters and guidewires that will be suitable for use in human patients, and (2) evaluate the safety of these devices in accord with FDA-established guidelines by calculating/measuring the additional heating caused by the presence of the intravascular MRI devices and assessing any potential for tissue damage. We will also (3) evaluate whether currently available perfusion MR imaging and non-invasive MR angiography (MR) techniques can be combined with IVMRI techniques to perform intravascular MR fluoroscopy (IVMRF)-guided interventional procedures, namely, balloon angioplasty and stent placement in animal models. In the final phase of the project, we plan to have enough data to apply for IRB approval for investigational use of these techniques in human patients.

近年来，我们开发了新型血管内磁共振成像（IVMRI）探头 用于动物模型的导丝和导管形式。我们有 还开发了 IVMRI 技术，能够获取高分辨率 血管壁的横截面图像以及跟踪技术 用于导管的实时可视化。我们相信使用这些 技术，可以获得对诊断和诊断有价值的信息。 治疗人类其他血管疾病的动脉粥样硬化。在这个 建议，我们将测试我们的 IVMRI 技术 () 的假设 低风险方法和（b）可用于可视化 介入技术，即球囊血管成形术和支架置入术 程序。具体来说，我们将 (1) 完善和调整我们现有的 IVMRI 导管和导丝形式的探头，适用于 在人类患者中使用，以及（2）评估这些设备的安全性 通过计算/测量，符合 FDA 制定的指南 血管内 MRI 设备的存在引起的额外热量 并评估任何潜在的组织损伤。我们还将 (3) 评估 目前是否可用灌注MR成像和无创MR 血管造影 (MR) 技术可以与 IVMRI 技术相结合 进行血管内 MR 透视 (IVMRF) 引导的介入治疗 程序，即动物体内的球囊血管成形术和支架置入术 模型。在项目的最后阶段，我们计划有足够的数据来 申请 IRB 批准这些技术的研究用途 人类患者。

项目成果

Tracking planar orientations of active MRI needles.

跟踪活动 MRI 针的平面方向。

• DOI: 10.1002/jmri.20960
• 发表时间: 2007
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Sathyanarayana,Shashank;Aksit,Pelin;Arepally,Aravind;Karmarkar,ParagV;Solaiyappan,Meiyappan;Atalar,Ergin
• 通讯作者: Atalar,Ergin

A Green's function approach to local rf heating in interventional MRI.

介入 MRI 中局部射频加热的格林函数方法。

• DOI: 10.1118/1.1367860
• 发表时间: 2001
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Yeung,CJ;Atalar,E
• 通讯作者: Atalar,E

MR-guided interventions for prostate cancer.

• DOI: 10.1016/j.mric.2005.04.012
• 发表时间: 2005-08-01
• 期刊: Magnetic resonance imaging clinics of North America
• 影响因子: 1.6
• 作者: Atalar, Ergin;Menard, Cynthia
• 通讯作者: Menard, Cynthia

Safety protocols for interventional MRI.

介入 MRI 的安全协议。

• DOI: 10.1016/j.acra.2005.05.025
• 发表时间: 2005
• 期刊: Academic radiology
• 影响因子: 4.8
• 作者: Hushek,StephenG;Russell,Lori;Moser,RobertF;Hoerter,NeilM;Moriarty,ThomasM;Shields,ChristopherB
• 通讯作者: Shields,ChristopherB