CREATIVITY AND LIABILITY FOR SCHIZOPHRENIA

精神分裂症的创造力和责任

• 批准号: 6126127
• 负责人: DENNIS K KINNEY
• 金额: $ 16.04万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6126127
• 关键词: behavior test; behavioral /social science research tag; behavioral genetics; clinical research; cognition; creativity; disease /disorder etiology; family genetics; genetic susceptibility; human subject; interview; mental disorder diagnosis; neuropsychological tests; occupations; perception; questionnaires; schizoid personality; schizophrenia; siblings; thinking

The study's broad, long-term objectives are to advance understanding of the relation of creativity to variables that are associated with liability for schizophrenia. The specific aims are to test hypotheses about the relation of creativity to liability for schizophrenia. The study will test: (a) whether previous reports of higher creativity in the relatives of schizophrenics and in individuals with multiple schizotypal signals can be confirmed with more rigorous methods, including new and larger samples, current diagnostic criteria, more sensitive measures of schizotypal features, and reliable measures of creativity shown in real-life activities. The study will also test (b) whether individuals with multiple schizotypal signals will similarly score significantly higher than controls on tests of creative thinking. The research design involves (a) samples of 70 schizophrenic probands, (b) 110 of their adult siblings, and (c) 110 normal controls. The sibling and control samples will be matched for age, gender, and ethnicity, and each group will be diagnosed using DSM-IV criteria and research interviews (SCID), supplemented by data from chart reviews and family informants. Schizotypal features will be assessed using the Structured Interview for Schizotypy and the Perceptual Aberration-Magical Thinking Scale. Subjects' creativity will be assessed, while blind to diagnostic data, using measures of real-life avocational and vocational creativity (the Lifetime Creativity Scales) as well as of creative thinking (the Torrance Tests of Creative Thinking). Rapid advances in the ability to detect genes for schizophrenia make it increasing important to know whether such genes may also be associated with beneficial behavioral traits. Knowledge that genes which increase risk for schizophrenia are also associated with creativity-enhancing traits would have important health implications for individuals and social decisions about how to apply new genetic knowledge.

这项研究的广泛、长期目标是促进对 创造力与负债相关变量的关系 精神分裂症 具体的目的是检验关于创造力关系的假设 精神分裂症的责任该研究将测试：（a）以前是否 精神分裂症患者的亲属和精神分裂症患者的亲属具有更高的创造力。 具有多个异型信号的个体可以用更多的 严格的方法，包括新的和更大的样本，当前的诊断 标准，更敏感的措施，典型特征，可靠 在现实生活中表现出的创造力。该研究还将 测试（B）具有多个典型信号的个体是否将 同样，在创造力测试中， 思维 研究设计包括（a）70例精神分裂症先证者的样本，（B） 110名成年同胞，和（c）110名正常对照。兄弟姐妹和 对照样本将在年龄、性别和种族方面匹配， 一组将使用DSM-IV标准和研究访谈进行诊断 （SCID），辅以图表审查和家庭线人的数据。 将使用结构化面谈评估分裂型特征， 精神分裂症和知觉偏差-魔幻思维量表。受试者的 创造力将被评估，而盲目的诊断数据，使用 现实生活中的财富和职业创造力的措施（终身 创造力量表）以及创造性思维（托兰斯测试， 创造性思维）。 精神分裂症基因检测能力的快速发展使得 越来越重要的是要知道这些基因是否也与 有益的行为特征我们知道， 精神分裂症的风险也与创造力的增强有关 性状将对个人和社会健康产生重要影响 决定如何应用新的遗传知识。