CREATIVITY AND LIABILITY FOR SCHIZOPHRENIA

该研究的广泛、长期目标是增进对 创造力与责任相关变量的关系 对于精神分裂症。 具体目的是检验关于创造力关系的假设 精神分裂症的责任。该研究将测试：(a) 以前是否 据报道，精神分裂症患者的亲属和 具有多种分裂型信号的个体可以通过更多的方法来确认 严格的方法，包括新的和更大的样本、当前的诊断 标准，对精神分裂特征的更敏感的测量，并且可靠 现实生活活动中表现出的创造力的衡量标准。该研究还将 测试 (b) 具有多重分裂型信号的个体是否会 同样，在创意测试中得分显着高于对照组 思考。 研究设计涉及 (a) 70 名精神分裂症先证者的样本，(b) 110 名成年兄弟姐妹，以及 (c) 110 名正常对照。兄弟姐妹和 对照样本将根据年龄、性别和种族进行匹配，并且每个样本 小组将使用 DSM-IV 标准和研究访谈进行诊断 (SCID)，并补充了来自图表评论和家庭线人的数据。 精神分裂症特征将通过结构化访谈进行评估 精神分裂和知觉失常-魔法思维量表。受试者的 将评估创造力，同时对诊断数据视而不见，使用 现实生活中的业余和职业创造力的衡量标准（终身 创造力量表）以及创造性思维（托伦斯测试） 创造性思维）。 检测精神分裂症基因能力的快速进步使其 了解这些基因是否也可能相关变得越来越重要 具有有益的行为特征。增加基因的知识 患精神分裂症的风险也与创造力增强有关 特征将对个人和社会产生重要的健康影响 关于如何应用新的遗传知识的决定。

The study's broad, long-term objectives are to advance understanding of the relation of creativity to variables that are associated with liability for schizophrenia. The specific aims are to test hypotheses about the relation of creativity to liability for schizophrenia. The study will test: (a) whether previous reports of higher creativity in the relatives of schizophrenics and in individuals with multiple schizotypal signals can be confirmed with more rigorous methods, including new and larger samples, current diagnostic criteria, more sensitive measures of schizotypal features, and reliable measures of creativity shown in real-life activities. The study will also test (b) whether individuals with multiple schizotypal signals will similarly score significantly higher than controls on tests of creative thinking. The research design involves (a) samples of 70 schizophrenic probands, (b) 110 of their adult siblings, and (c) 110 normal controls. The sibling and control samples will be matched for age, gender, and ethnicity, and each group will be diagnosed using DSM-IV criteria and research interviews (SCID), supplemented by data from chart reviews and family informants. Schizotypal features will be assessed using the Structured Interview for Schizotypy and the Perceptual Aberration-Magical Thinking Scale. Subjects' creativity will be assessed, while blind to diagnostic data, using measures of real-life avocational and vocational creativity (the Lifetime Creativity Scales) as well as of creative thinking (the Torrance Tests of Creative Thinking). Rapid advances in the ability to detect genes for schizophrenia make it increasing important to know whether such genes may also be associated with beneficial behavioral traits. Knowledge that genes which increase risk for schizophrenia are also associated with creativity-enhancing traits would have important health implications for individuals and social decisions about how to apply new genetic knowledge.