CREATIVITY AND LIABILITY FOR SCHIZOPHRENIA

这项研究的广泛和长期目标是促进对 创造力与与责任相关的变量的关系 治疗精神分裂症。 其具体目的是检验有关创造力关系的假设 精神分裂症的责任。这项研究将测试：(A)以前的 精神分裂症患者亲属和老年人创造力较高的报道 有多个分裂型信号的个体可以用更多的 严格的方法，包括新的和更大的样本，当前的诊断 标准，更敏感的分裂类型特征测量，以及可靠的 在现实生活活动中展示的创造力的衡量标准。这项研究还将 测试(B)有多个分裂型信号的个体是否会 同样，在创造力测试中，得分也明显高于对照组 思考。 研究设计包括(A)70名精神分裂症先证者的样本，(B) 110名成年同胞，以及(C)110名正常对照。兄弟姐妹和 对照样本将根据年龄、性别和种族进行匹配，每个 将使用DSM-IV标准和研究访谈对小组进行诊断 (SCID)，由图表审查和家庭告密者提供的数据补充。 分裂类型特征将使用结构化面谈进行评估 分裂类型与知觉偏差-魔力思考量表。受试者的 创造力将被评估，同时对诊断数据视而不见，使用 现实生活中业余和职业创造力的测量(终生 创造力量表)以及创造性思维(托兰斯测试 创造性思维)。 精神分裂症基因检测能力的快速进步使其 了解这些基因是否也可能相关变得越来越重要 具有有益的行为特征。认识到增加的基因 患精神分裂症的风险也与增强创造力有关 这些特征将对个人和社会产生重要的健康影响 关于如何应用新的遗传知识的决定。

The study's broad, long-term objectives are to advance understanding of the relation of creativity to variables that are associated with liability for schizophrenia. The specific aims are to test hypotheses about the relation of creativity to liability for schizophrenia. The study will test: (a) whether previous reports of higher creativity in the relatives of schizophrenics and in individuals with multiple schizotypal signals can be confirmed with more rigorous methods, including new and larger samples, current diagnostic criteria, more sensitive measures of schizotypal features, and reliable measures of creativity shown in real-life activities. The study will also test (b) whether individuals with multiple schizotypal signals will similarly score significantly higher than controls on tests of creative thinking. The research design involves (a) samples of 70 schizophrenic probands, (b) 110 of their adult siblings, and (c) 110 normal controls. The sibling and control samples will be matched for age, gender, and ethnicity, and each group will be diagnosed using DSM-IV criteria and research interviews (SCID), supplemented by data from chart reviews and family informants. Schizotypal features will be assessed using the Structured Interview for Schizotypy and the Perceptual Aberration-Magical Thinking Scale. Subjects' creativity will be assessed, while blind to diagnostic data, using measures of real-life avocational and vocational creativity (the Lifetime Creativity Scales) as well as of creative thinking (the Torrance Tests of Creative Thinking). Rapid advances in the ability to detect genes for schizophrenia make it increasing important to know whether such genes may also be associated with beneficial behavioral traits. Knowledge that genes which increase risk for schizophrenia are also associated with creativity-enhancing traits would have important health implications for individuals and social decisions about how to apply new genetic knowledge.