BRAIN TISSUE RESOURCE FOR NEUROPSYCHIATRIC RESEARCH

用于神经精神病学研究的脑组织资源

• 批准号: 6185925
• 负责人: FRANCINE M. BENES
• 金额: $ 89.69万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6185925
• 关键词: Alzheimer's disease; Huntington's disease; Internet; Parkinson's disease; bipolar depression; brain; brain disorders; histopathology; human tissue; information dissemination; information systems; mental disorders; neuropathology; neurosciences; patient /disease registry; postmortem; schizophrenia; tissue resource /registry

The Harvard Brain Tissue Resource Center is a national resource for the acquisition, processing, storage and distribution of postmortem (PM) brain specimens from normal controls (CON), as well as individuals with a variety of movement disorders (Huntington's chorea and Parkinson's disease), dementia (Alzheimer's disease) and major psychoses (schizophrenia and bipolar disorder). For the past 20 years, the HBTRC has been distributing tissue specimens to neuroanatomists, neuropathologists, neuropharmacologists, neurochemists and molecular biologists. In so doing, this facility has acted as a "seed" for more than 150 scientific publications, most having appeared in distinguished refereed journals. In the past 1.5 years, the HBTRC has undergone a major re-structuring that has resulted in an increase in the overall quality and efficiency of its operation. An important outcome of this re-organization has been an increase in the overall number of fresh cases acquired and a marked decrease in the length of the postmortem interval (PMI). As a result of this effort, abundant tissue suitable for a broad array of state-of-the-art research applications can now be provided to the neuroscience community. Since the number of CONs received in the past year has also been increased by 50 percent and is projected to increase by as much as 100 percent over the next year, the HBTRC is now able to match CONs for age, PMI and gender with respect to a variety of brain disordered groups. For the major psychoses, where the acquisition of PM brains is extremely difficult, the number of cases has also been increased by 50 percent in the past 1.5 years. Since these are largely from community-based referrals, the potential confounding effects of institutionalization, inanition and substance abuse will be reduced in studies of the psychiatric disorders. The HBTRC has established a website with information for potential donors and their families, pathologists involved in brain removal, as well as investigators seeking tissue for their research; all necessary forms can now be downloaded from the "Net." Most recently, the HBTRC has been developing a user-interactive database for the Internet so that investigators who receive tissue from the "bank" can obtain demographics, neuropathology reports and images of gross dissections and histological slides for their cases. Over the next five years, all of these changes will enhance the "brain bank" in its role as a vital national resource.

哈佛大学脑组织资源中心是国家资源 验尸的获取，处理，存储和分布（PM） 来自正常对照（CON）的大脑标本以及 各种运动障碍（亨廷顿的唱片和帕金森氏症 疾病），痴呆症（阿尔茨海默氏病）和主要精神病 （精神分裂症和躁郁症）。 在过去的20年中，HBTRC 一直在将组织标本分发给神经解剖学家， 神经病理学家，神经药物学家，神经化学家和分子 生物学家。 这样做，这个设施充当了更多的“种子” 超过150个科学出版物，大多数出现在杰出的 裁量期刊。 在过去的1。5年中，HBTRC经历了A 重新结构的重新结构导致整体增加 其运营的质量和效率。 一个重要的结果 重组的整体数量增加了 获取的案例，并明显减少验尸的长度 间隔（PMI）。 由于这项工作，丰富的组织适合 对于各种最先进的研究应用程序，现在可以 提供给神经科学社区。 由于缺点的数量 过去一年收到的也增加了50％，是 预计明年将增长多达100％ HBTRC现在能够与年龄，PMI和性别相匹配 各种大脑失调组。 对于主要的精神病 PM大脑的获取极为困难，案例数 在过去的1。5年中，也增加了50％。 自从 这些主要来自基于社区的推荐，潜力 制度化，罪行和实质的混淆影响 精神疾病的研究将减少虐待。 这 HBTRC建立了一个网站，并提供了潜在捐助者的信息 以及他们的家人，参与清除大脑的病理学家以及 研究人员寻求组织进行研究；所有必要的形式都可以 现在从“网”下载。 最近，HBTRC一直 为Internet开发用户交互数据库 从“银行”接收组织的调查人员可以获得 人口统计学，神经病理学的报告和图像 组织学幻灯片的案例。 在接下来的五年中，所有 这些变化将增强“大脑银行”的角色 国家资源。