PHYSIOLOGY AND PATHOPHYSIOLOGY OF THE PRIMATE GONAD

匹兹堡大学医学院拟议的生殖专业合作中心的使命是，通过整合分子、细胞和系统方法，研究灵长类动物性腺功能的生理机制，并调查人类不育特定状态的病理生理学基础，在这些情况下，对非人类灵长类动物的平行和交互研究可能特别有意义。这项任务反映了该中心长期以来的长处，即使用非人类灵长类动物模型来更好地了解人类生殖的生理学。该中心将由3个技术服务核心(Primate、Assay和细胞成像)组成，采用开放访问格式，为U54项目和由R01(7)或R29(1)赠款支持的其他项目提供支持。U54项目的重点是控制灵长类动物的性腺功能。从概念上讲，他们紧密地联系在一个主题上，即FSH在调节卵巢和睾丸功能方面发挥着基础性作用，对这种促性腺激素的控制和作用机制的研究将为男性和女性不孕不育的治疗提供洞察。此外，预计一个项目的进展将对其他项目产生影响，这一点在项目I和项目II中得到了例证。第一个项目将研究高胰岛素血症和高雄激素血症在多囊卵巢综合征女性促性腺激素分泌异常模式(与黄体生成素脉冲频率升高相关的黄体生成素/卵泡刺激素比率增加)和无排卵中的作用。这项临床工作是与一个使用非人类灵长类动物模型的项目同步进行的，该项目旨在研究胰岛素和雄激素对正常排卵猴子脑垂体轴/卵巢轴的作用。其余的U54项目也采用了非人类灵长类模型。它研究了精子产生由FSH抑制B反馈回路控制的控制机制。

The mission of the proposed Specialized Cooperative Center in Reproduction at the University of Pittsburgh Medical School is to study, by integrating molecular, cellular and system approaches, the physiological mechanisms that govern gonadal function in primates, and to investigate the pathophysiological bases of specific states of human infertility where parallel and interactive studies of non-human primates are likely to be particularly rewarding. This mission reflects the long- standing forte of this Center to employ non-human primate models to better understand the physiology of reproduction in man. The Center will be comprised of 3 Technical Service Cores (Primate, Assay and Cell Imaging) with an open access format to subserve U54 Projects and additional programs supported by either R01 (7) or R29(1) grants. The U54 Projects focus on the control of gonadal function in primates. Conceptually, they are tightly linked by the theme that FSH plays a fundamental role in the regulation of both ovarian and testicular function, and that the study of the control, and mechanism of action, of this gonadotropin will provide insight into treatment of infertility in men and women. Moreover, it is anticipated that advance sin one project will impact upon the others, and this is exemplified by projects I and II. The first of which will examine the roles of hyperinsulinemia and hyperandrogenemia in producing aberrant patterns of gonadotropin secretion (increased LH:FSH ratios in association with elevated LH pulse frequency) and anovulation in women with polycystic ovarian syndrome. This clinical endeavor is placed in tandem is placed in tandem with a project employing a non-human primate model to examine the action of insulin and androgen on the pituitary/ovarian axis in normal ovulatory monkeys. The remaining U54 projects also employs non-human primate model. It examines the control mechanism whereby sperm production is governed by the FSH-inhibition B feedback loop.