PHYSIOLOGY AND PATHOPHYSIOLOGY OF THE PRIMATE GONAD

匹兹堡大学医学院拟建的生殖专业合作中心的使命是，通过整合分子、细胞和系统方法，研究控制灵长类动物性腺功能的生理机制，并研究人类不孕症特定状态的病理生理学基础，其中对非人类灵长类动物的并行和互动研究可能特别有价值。这一使命反映了该中心长期以来的优势，即利用非人类灵长类动物模型来更好地了解人类生殖的生理学。该中心将由 3 个技术服务核心（灵长类动物、检测和细胞成像）组成，采用开放获取格式，以支持 U54 项目和 R01 (7) 或 R29(1) 拨款支持的其他项目。 U54 项目重点关注灵长类动物性腺功能的控制。从概念上讲，它们与以下主题紧密相连：FSH 在卵巢和睾丸功能的调节中发挥着基础作用，并且对这种促性腺激素的控制和作用机制的研究将为男性和女性不孕症的治疗提供见解。此外，预计一个项目的进展将会影响其他项目，项目一和项目二就是例证。其中第一个将检查高胰岛素血症和高雄激素血症在促性腺激素分泌异常模式（LH:FSH 比率增加与 LH 脉冲频率升高相关）和多囊卵巢综合征女性无排卵中的作用。这项临床工作与一个项目同时进行，该项目采用非人类灵长类动物模型来检查胰岛素和雄激素对正常排卵猴的垂体/卵巢轴的作用。其余的U54项目也采用非人类灵长类动物模型。它检查了精子产生受 FSH 抑制 B 反馈回路控制的控制机制。

The mission of the proposed Specialized Cooperative Center in Reproduction at the University of Pittsburgh Medical School is to study, by integrating molecular, cellular and system approaches, the physiological mechanisms that govern gonadal function in primates, and to investigate the pathophysiological bases of specific states of human infertility where parallel and interactive studies of non-human primates are likely to be particularly rewarding. This mission reflects the long- standing forte of this Center to employ non-human primate models to better understand the physiology of reproduction in man. The Center will be comprised of 3 Technical Service Cores (Primate, Assay and Cell Imaging) with an open access format to subserve U54 Projects and additional programs supported by either R01 (7) or R29(1) grants. The U54 Projects focus on the control of gonadal function in primates. Conceptually, they are tightly linked by the theme that FSH plays a fundamental role in the regulation of both ovarian and testicular function, and that the study of the control, and mechanism of action, of this gonadotropin will provide insight into treatment of infertility in men and women. Moreover, it is anticipated that advance sin one project will impact upon the others, and this is exemplified by projects I and II. The first of which will examine the roles of hyperinsulinemia and hyperandrogenemia in producing aberrant patterns of gonadotropin secretion (increased LH:FSH ratios in association with elevated LH pulse frequency) and anovulation in women with polycystic ovarian syndrome. This clinical endeavor is placed in tandem is placed in tandem with a project employing a non-human primate model to examine the action of insulin and androgen on the pituitary/ovarian axis in normal ovulatory monkeys. The remaining U54 projects also employs non-human primate model. It examines the control mechanism whereby sperm production is governed by the FSH-inhibition B feedback loop.