SPERMATOGENESIS IN FSH INHIBIN B FEEDBACK

FSH 抑制素 B 反馈中的精子发生

• 批准号: 6588480
• 负责人: TONY M PLANT
• 金额: $ 17.64万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6588480
• 关键词: Macaca mulatta; biological models; cooperative study; fertility; follicle stimulating hormone; hormone biosynthesis; hormone receptor; hormone regulation /control mechanism; inhibin; laboratory rat; male; molecular cloning; pituitary gland; spermatogenesis

Description: The overall goal of this project is to determine the physiological importance of the FSH-inhibin B feedback loop in sperm production in the non-human primate and to describe the cellular mechanisms involved in both the pituitary and testis. Five specific aims are proposed. These include (1) to test the hypothesis that testicular inhibin B secretion is the key negative feedback signal that determines, via its effect on FSH release, the number of sperm produced; (2) to identify the paracrine mechanisms within the testis whereby FSH enlarges the population of differentiated spermatogonia; (3) to clone the gene encoding inhibin alpha and the inhibin receptor in the monkey and to produce sufficient monkey inhibin B for in vitro studies; (4) to localize the inhibin receptor in the pituitary and to study its role in mediating the negative feedback control of FSH by inhibin B; (5) to examine the hypothesis that the germinal epithelium is the principal regulator of Sertoli cell inhibin B secretion and that the physiological role of FSH in this regard is largely permissive.

描述：本项目的总体目标是确定 精子中FSH-β B反馈环的生理学意义 在非人类灵长类动物中的生产，并描述细胞机制 参与了脑垂体和睾丸提出了五个具体目标。 这些包括（1）检验睾丸β-受体结合素B分泌的假设， 是关键的负反馈信号，通过其对FSH的影响， 释放，产生精子的数量;（2）确定旁分泌 睾丸内的机制，从而FSH扩大人口的 （3）克隆了人精原细胞分化因子α的编码基因， 并产生足够的猴胰蛋白酶B B 用于体外研究;（4）定位垂体中的Escherichin受体 并研究其在介导FSH负反馈控制中的作用， （5）检验生殖上皮是生殖细胞的主要来源的假说， Sertoli细胞分泌抑制素B的主要调节因子， FSH在这方面的生理作用在很大程度上是允许的。