SPERMATOGENESIS IN FSH INHIBIN B FEEDBACK

FSH 抑制素 B 反馈中的精子发生

• 批准号: 6588480
• 负责人: TONY M PLANT
• 金额: $ 17.64万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6588480
• 关键词: Macaca mulatta; biological models; cooperative study; fertility; follicle stimulating hormone; hormone biosynthesis; hormone receptor; hormone regulation /control mechanism; inhibin; laboratory rat; male; molecular cloning; pituitary gland; spermatogenesis

Description: The overall goal of this project is to determine the physiological importance of the FSH-inhibin B feedback loop in sperm production in the non-human primate and to describe the cellular mechanisms involved in both the pituitary and testis. Five specific aims are proposed. These include (1) to test the hypothesis that testicular inhibin B secretion is the key negative feedback signal that determines, via its effect on FSH release, the number of sperm produced; (2) to identify the paracrine mechanisms within the testis whereby FSH enlarges the population of differentiated spermatogonia; (3) to clone the gene encoding inhibin alpha and the inhibin receptor in the monkey and to produce sufficient monkey inhibin B for in vitro studies; (4) to localize the inhibin receptor in the pituitary and to study its role in mediating the negative feedback control of FSH by inhibin B; (5) to examine the hypothesis that the germinal epithelium is the principal regulator of Sertoli cell inhibin B secretion and that the physiological role of FSH in this regard is largely permissive.

描述：该项目的总体目标是确定 精子中FSH抑制素B反馈回路的生理重要性 在非人类灵长类动物中生产并描述细胞机制 参与垂体和睾丸。提出了五个具体目标。 其中包括（1）测试睾丸抑制素B分泌的假设 是通过对FSH的影响确定的关键负反馈信号 释放，产生的精子数； （2）识别旁分泌 睾丸内的机制，FSH扩大了种群 分化的精子症； （3）克隆编码抑制剂α和 猴子中的抑制素受体并产生足够的猴子抑制剂B 用于体外研究； （4）将抑制素受体定位在垂体中 并研究其在调解FSH负面反馈控制中的作用 抑制素B; （5）检查了生发上皮是 Sertoli细胞抑制素B分泌的主要调节剂， FSH在这方面的生理作用在很大程度上是允许的。