CORE--DATA ANALYSIS, STATISTICAL SUPPORT, SPECIMAN BANK

该计划项目的核心提供了一组资源、服务， 和技能，这是必不可少的组成项目的行为。 其中包括： 1.协调和支持。威利特博士将协调并提供 在本计划内开展的项目的总体方向。核心 工作人员将提供行政协助和秘书处支助， 个别项目，并促进他们之间的沟通。 2.半定量食物频率问卷分析系统。 该调查问卷和营养分析系统是一个基本资源， 被用于所有的成分研究，以及许多其他 我们机构内外的调查员核心将支持 高级营养师，负责维护和开发 在营养分析系统中使用的食物成分数据库 随附问卷。 3.统计服务。Donna Spiegelman博士将提供统计数据 支持本提案中的所有项目。 4.计算和编程设施。核心将提供 所有组件的计算机硬件和软件资源 项目这一计算机设施还与护士的 健康研究I和II。核心中的程序员将安排 各组成项目和其他大型群组之间的数据转移 数据库，并支持营养素的维护和开发 分析系统，并将实验室分析结果与我们的 现有流行病学数据进行巢式病例对照分析。 5.生物标本库。血液，储存在血浆等分试样中，浅黄色 大衣，和红细胞在液氮冷冻，可为18000 参与卫生专业人员随访研究，并将用于 项目I、II和单独资助的研究。核心将支持 监测和维护这一宝贵资源，以及 标本检索、等分和运送到合作地点 laboratories.

The Core for this Program Project provides a group of resources, services, and skills that are essential for the conduct of the component projects. These consist of: 1. Coordination and Support. Dr. Willett will coordinate and provide the overall direction for the projects conducted within this Program. The Core staff will provide administrative assistance and secretarial support for the individual projects and facilitate communications among them. 2. The Semi-Quantitative Food Frequency Questionnaire Analysis System. This questionnaire and nutrient analysis system is a basic resource that is used in all of the component studies, as well as by many other investigators within and outside our institution. The Core will support a Senior Dietitian with responsibility for maintaining and developing the food composition database used in the nutrient analysis system that accompanies the questionnaire. 3. Statistical Services. Dr. Donna Spiegelman will provide statistical support for all of the projects within this proposal. 4. Computing and Programming Facilities. The Core will provide the computer hardware and software resources for all of the component Projects. This computer facility is also coordinated with the Nurses' Health Studies I and II. A programmer included in the Core will arrange transfer of data among the component projects and other large cohort databases, and support the maintenance and development of the nutrient analysis system, and integrate the results of laboratory analyses with our existing epidemiology data for nested case-control analyses. 5. Biological Specimen Bank. Bloods, stored in aliquots of plasma, buffy coat, and red cells in liquid nitrogen freezers, are available for 18,000 participants in the Health Professionals Follow-up Study and will be used for Projects I, II, and separately funded research. The core will support the monitoring and maintenance of this valuable resource as well as specimen retrieval, aliquoting, and shipping to collaborating laboratories.