Validity of Diet and Activity Measures in Women

女性饮食和活动措施的有效性

基本信息

  • 批准号:
    7816062
  • 负责人:
  • 金额:
    $ 625.13万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-09-30 至 2012-09-29
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Large prospective studies of diet and cancer have often not supported hypotheses that were based on animal and ecological findings; one possible explanation could be large measurement errors in the assessment of diet. Thus, NCI has requested proposals for a series collaborative validation/calibration studies imbedded in existing cohorts using a common design with multiple self-reported and biomarker measures of diet and physical activity including doubly labeled water (DLW), urinary nitrogen (UN) and motion monitors. Thus, we propose to conduct such a study among 750 women in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHSN), which will be of particular value because these cohorts have provided much of the data that have not supported several prominent hypotheses. Also, in these studies we have already collected extensive dietary data using multiple measures of intake and plasma biomarkers of diet; this will allow the evaluation of the validity of dietary assessment methods over a 20-year period. The proposed study design will consist of two FFQ's administered one year apart; in the year between these measures we will collect four 24-hour recalls using the new NCI automated self-administered 24-hour recall (ASA24), two 7-day dietary records, and biomarkers of diet including one assessment of energy expenditure using doubly-labeled water (DLW, with a replication in 100 women), four 24-hour urinary measures of nitrogen (a measure of protein intake), sodium and potassium, and two fasting blood samples for plasma levels of specific fatty acids, standard lipids, carotenoids, and folate. Physical activity will be assessed twice (together with the FFQ's) by the modified Paffenbarger physical activity questionnaire used in our studies, four 24-hour recalls using an automated system developed by the NCI, twice by an objective physical activity monitor, and by DLW (subtracting resting metabolic rate). These multiple measurements will allow an evaluation of the error structure associated with dietary and physical activity assessment methods, in particular the influences of variation over time for each method and correlated errors between methods. This will provide information of the relative and absolute validity of the different measures, and inform the interpretation of the published literature on diet and cancer (allowing the correction of observed relative risks and confidence intervals for measurement error) and the design of future validation/calibration studies. Additional analyses will indicate the optimal approaches to adjust nutrient intakes for total energy intake, which is critical for the interpretation of epidemiologic findings. PUBLIC HEALTH RELEVANCE: The proposed validation/calibration study will provide quantitative data on the validity of the methods that have been used in cohort studies to measure diet and physical activity. This information would greatly enhance the value of the data that have been collected and would also provide invaluable guidance for the design and collection of future data on diet and physical activity and cancer by other investigators, resulting in great benefit to public health.
描述(由申请人提供):关于饮食和癌症的大型前瞻性研究往往不支持基于动物和生态发现的假设;一个可能的解释是饮食评估中的巨大测量误差。因此,NCI已经征求了一系列合作验证/校准研究的建议,这些研究嵌入在现有的队列中,使用共同的设计,包括饮食和体力活动的多个自我报告和生物标记物测量,包括双标记水(DLW)、尿氮(UN)和运动监测器。因此,我们建议在护士健康研究(NHS)和护士健康研究II(NHSN)中对750名女性进行这样的研究,这将是特别有价值的,因为这些队列提供了许多数据,而这些数据并没有支持几个突出的假设。此外,在这些研究中,我们已经使用多种饮食摄入量和血浆生物标记物收集了广泛的饮食数据;这将允许在20年内评估饮食评估方法的有效性。拟议的研究设计将包括相隔一年实施的两次FFQ;在这些措施之间的一年中,我们将使用新的NCI自动24小时召回(ASA24)收集四次24小时召回、两次7天饮食记录和饮食生物标记物,包括一次使用双标签水(DLW,在100名女性中复制)的能量消耗评估,四次24小时尿氮(蛋白质摄入量)、钠和钾的测量,以及两次空腹血液样本,用于血浆特定脂肪酸、标准血脂、类胡萝卜素和叶酸的水平。体力活动将通过我们研究中使用的修改后的Paffenbarger体力活动问卷进行两次评估(与FFQ一起),使用NCI开发的自动系统进行四次24小时召回,通过客观体力活动监测器和DLW(减去静息代谢率)进行两次评估。这些多重测量将允许评估与饮食和体力活动评估方法有关的误差结构,特别是每种方法随时间变化的影响以及方法之间的相关误差。这将提供不同措施的相对和绝对有效性的信息,并为关于饮食和癌症的已发表文献的解释(允许纠正观察到的相对风险和测量误差的可信区间)和未来验证/校准研究的设计提供信息。其他分析将指出调整总能量摄入量的营养摄入量的最佳方法,这对解释流行病学结果至关重要。公共卫生相关性:拟议的验证/校准研究将提供定量数据,说明队列研究中用于测量饮食和体力活动的方法的有效性。这些信息将大大提高已经收集的数据的价值,并将为其他调查人员设计和收集未来关于饮食和体力活动与癌症的数据提供宝贵的指导,从而对公众健康产生巨大的好处。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Walter C. Willett其他文献

Dietary fat and breast cancer.
膳食脂肪和乳腺癌。
  • DOI:
    10.1093/jnci/90.17.1303-b
  • 发表时间:
    1991
  • 期刊:
  • 影响因子:
    0
  • 作者:
    David J. Hunter;Donna Spiegelman;Walter C. Willett
  • 通讯作者:
    Walter C. Willett
Hypertension detection and follow-up program study of serum retinol, retinol-binding protein, total carotenoids, and cancer risk: a summary.
血清视黄醇、视黄醇结合蛋白、总类胡萝卜素和癌症风险的高血压检测和随访计划研究:总结。
  • DOI:
  • 发表时间:
    1984
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Walter C. Willett;Walter C. Willett;B. Polk;Barbara A. Underwood;Curtis G. Hames
  • 通讯作者:
    Curtis G. Hames
Optimal dietary patterns for healthy aging
健康老龄化的最佳饮食模式
  • DOI:
    10.1038/s41591-025-03570-5
  • 发表时间:
    2025-03-24
  • 期刊:
  • 影响因子:
    50.000
  • 作者:
    Anne-Julie Tessier;Fenglei Wang;Andres Ardisson Korat;A. Heather Eliassen;Jorge Chavarro;Francine Grodstein;Jun Li;Liming Liang;Walter C. Willett;Qi Sun;Meir J. Stampfer;Frank B. Hu;Marta Guasch-Ferré
  • 通讯作者:
    Marta Guasch-Ferré
Sugar-sweetened beverage consumption and weight gain in children and adults: a systematic review and meta-analysis of prospective cohort studies and randomized controlled trials
儿童和成人含糖饮料消费与体重增加:前瞻性队列研究和随机对照试验的系统综述和荟萃分析
  • DOI:
    10.1016/j.ajcnut.2022.11.008
  • 发表时间:
    2023-01-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Michelle Nguyen;Sarah E. Jarvis;Maria G. Tinajero;Jiayue Yu;Laura Chiavaroli;Sonia Blanco Mejia;Tauseef A. Khan;Deirdre K. Tobias;Walter C. Willett;Frank B. Hu;Anthony J. Hanley;Catherine S. Birken;John L. Sievenpiper;Vasanti S. Malik
  • 通讯作者:
    Vasanti S. Malik
442: Fish Consumption and Prostate Cancer Recurrence - Health Professionals Follow-Up Study
  • DOI:
    10.1016/s0022-5347(18)37704-8
  • 发表时间:
    2004-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    June M. Chan;Crystal N. Holick;Michael F. Leitzmann;Meir J. Stampfer;Eric B. Rimm;Walter C. Willett;Edward Giovannucci
  • 通讯作者:
    Edward Giovannucci

Walter C. Willett的其他文献

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{{ truncateString('Walter C. Willett', 18)}}的其他基金

Life Course Cancer Epidemiology Cohort in Women
女性生命历程癌症流行病学队列
  • 批准号:
    8651432
  • 财政年份:
    2013
  • 资助金额:
    $ 625.13万
  • 项目类别:
Life Course Cancer Epidemiology Cohort in Women
女性生命历程癌症流行病学队列
  • 批准号:
    8513463
  • 财政年份:
    2013
  • 资助金额:
    $ 625.13万
  • 项目类别:
Life Course Cancer Epidemiology Cohort in Women
女性生命历程癌症流行病学队列
  • 批准号:
    9280875
  • 财政年份:
    2013
  • 资助金额:
    $ 625.13万
  • 项目类别:
Cancer Epidemiology Cohort in Male Health Professionals
男性健康专业人员中的癌症流行病学队列
  • 批准号:
    8534745
  • 财政年份:
    2012
  • 资助金额:
    $ 625.13万
  • 项目类别:
Cancer Epidemiology Cohort in Male Health Professionals
男性健康专业人员中的癌症流行病学队列
  • 批准号:
    8298342
  • 财政年份:
    2012
  • 资助金额:
    $ 625.13万
  • 项目类别:
Breast Cancer
乳腺癌
  • 批准号:
    7786693
  • 财政年份:
    2010
  • 资助金额:
    $ 625.13万
  • 项目类别:
Prospective Studies of Diet and Cancer in Men and Women
男性和女性饮食与癌症的前瞻性研究
  • 批准号:
    7929964
  • 财政年份:
    2009
  • 资助金额:
    $ 625.13万
  • 项目类别:
Cysteine, Related Gene Variants and Breast Cancer Risk
半胱氨酸、相关基因变异和乳腺癌风险
  • 批准号:
    7488799
  • 财政年份:
    2007
  • 资助金额:
    $ 625.13万
  • 项目类别:
Cysteine, Related Gene Variants and Breast Cancer Risk
半胱氨酸、相关基因变异和乳腺癌风险
  • 批准号:
    7666316
  • 财政年份:
    2007
  • 资助金额:
    $ 625.13万
  • 项目类别:
Cysteine, Related Gene Variants and Breast Cancer Risk
半胱氨酸、相关基因变异和乳腺癌风险
  • 批准号:
    7890406
  • 财政年份:
    2007
  • 资助金额:
    $ 625.13万
  • 项目类别:

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