Validity of Diet and Activity Measures in Women

女性饮食和活动措施的有效性

基本信息

  • 批准号:
    7816062
  • 负责人:
  • 金额:
    $ 625.13万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-09-30 至 2012-09-29
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Large prospective studies of diet and cancer have often not supported hypotheses that were based on animal and ecological findings; one possible explanation could be large measurement errors in the assessment of diet. Thus, NCI has requested proposals for a series collaborative validation/calibration studies imbedded in existing cohorts using a common design with multiple self-reported and biomarker measures of diet and physical activity including doubly labeled water (DLW), urinary nitrogen (UN) and motion monitors. Thus, we propose to conduct such a study among 750 women in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHSN), which will be of particular value because these cohorts have provided much of the data that have not supported several prominent hypotheses. Also, in these studies we have already collected extensive dietary data using multiple measures of intake and plasma biomarkers of diet; this will allow the evaluation of the validity of dietary assessment methods over a 20-year period. The proposed study design will consist of two FFQ's administered one year apart; in the year between these measures we will collect four 24-hour recalls using the new NCI automated self-administered 24-hour recall (ASA24), two 7-day dietary records, and biomarkers of diet including one assessment of energy expenditure using doubly-labeled water (DLW, with a replication in 100 women), four 24-hour urinary measures of nitrogen (a measure of protein intake), sodium and potassium, and two fasting blood samples for plasma levels of specific fatty acids, standard lipids, carotenoids, and folate. Physical activity will be assessed twice (together with the FFQ's) by the modified Paffenbarger physical activity questionnaire used in our studies, four 24-hour recalls using an automated system developed by the NCI, twice by an objective physical activity monitor, and by DLW (subtracting resting metabolic rate). These multiple measurements will allow an evaluation of the error structure associated with dietary and physical activity assessment methods, in particular the influences of variation over time for each method and correlated errors between methods. This will provide information of the relative and absolute validity of the different measures, and inform the interpretation of the published literature on diet and cancer (allowing the correction of observed relative risks and confidence intervals for measurement error) and the design of future validation/calibration studies. Additional analyses will indicate the optimal approaches to adjust nutrient intakes for total energy intake, which is critical for the interpretation of epidemiologic findings. PUBLIC HEALTH RELEVANCE: The proposed validation/calibration study will provide quantitative data on the validity of the methods that have been used in cohort studies to measure diet and physical activity. This information would greatly enhance the value of the data that have been collected and would also provide invaluable guidance for the design and collection of future data on diet and physical activity and cancer by other investigators, resulting in great benefit to public health.
描述(由申请人提供):关于饮食和癌症的大型前瞻性研究通常不支持基于动物和生态学发现的假设;一个可能的解释可能是饮食评估中存在较大的测量误差。因此,NCI已要求在现有队列中进行一系列协作验证/校准研究的建议,这些研究使用通用设计,包括饮食和体力活动的多个自我报告和生物标志物测量,包括双标记水(DLW),尿氮(UN)和运动监测器。因此,我们建议在护士健康研究(NHS)和护士健康研究II(NHSN)中的750名女性中进行这样的研究,这将具有特别的价值,因为这些队列提供了许多不支持几个突出假设的数据。此外,在这些研究中,我们已经使用多种摄入量和饮食的血浆生物标志物收集了广泛的饮食数据;这将允许在20年的时间内评估饮食评估方法的有效性。拟定的研究设计将包括间隔一年进行的两次FFQ;在这些措施之间的一年中,我们将使用新的NCI自动自我管理24小时回忆(ASA 24)收集4次24小时回忆,两次7天饮食记录和饮食生物标志物,包括使用双标记水评估能量消耗(DLW,在100名女性中重复),四个24小时尿氮(蛋白质摄入量的测量),钠和钾的测量,以及两个特定脂肪酸,标准脂质,类胡萝卜素和叶酸的血浆水平的空腹血液样本。将通过我们研究中使用的改良Paffenbarger体力活动问卷评估体力活动两次(连同FFQ),使用NCI开发的自动化系统进行四次24小时回忆,通过客观体力活动监测器评估两次,以及通过DLW(减去静息代谢率)评估体力活动。这些多重测量将允许评估与饮食和身体活动评估方法相关的误差结构,特别是每种方法随时间变化的影响以及方法之间的相关误差。这将提供不同措施的相对和绝对有效性的信息,并为解释有关饮食和癌症的已发表文献提供信息(允许校正观察到的相对风险和测量误差的置信区间)以及设计未来的验证/校准研究。其他分析将指出调整营养素摄入量的最佳方法,总能量摄入量,这是流行病学调查结果的解释至关重要。公共卫生相关性:拟议的验证/校准研究将提供有关队列研究中用于测量饮食和身体活动的方法有效性的定量数据。这些信息将大大提高已收集数据的价值,并为其他研究人员设计和收集未来关于饮食和身体活动与癌症的数据提供宝贵的指导,从而极大地造福于公共卫生。

项目成果

期刊论文数量(0)
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会议论文数量(0)
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Walter C. Willett其他文献

Hypertension detection and follow-up program study of serum retinol, retinol-binding protein, total carotenoids, and cancer risk: a summary.
血清视黄醇、视黄醇结合蛋白、总类胡萝卜素和癌症风险的高血压检测和随访计划研究:总结。
  • DOI:
  • 发表时间:
    1984
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Walter C. Willett;Walter C. Willett;B. Polk;Barbara A. Underwood;Curtis G. Hames
  • 通讯作者:
    Curtis G. Hames
Dietary fat and breast cancer.
膳食脂肪和乳腺癌。
  • DOI:
    10.1093/jnci/90.17.1303-b
  • 发表时间:
    1991
  • 期刊:
  • 影响因子:
    0
  • 作者:
    David J. Hunter;Donna Spiegelman;Walter C. Willett
  • 通讯作者:
    Walter C. Willett
Correction: Hormone-associated dietary patterns and premenopausal breast cancer risk
  • DOI:
    10.1007/s10549-025-07706-6
  • 发表时间:
    2025-04-24
  • 期刊:
  • 影响因子:
    3.000
  • 作者:
    Sable N. Fest;Leslie V. Farland;David R. Doody;A. Heather Eliassen;Bernard A. Rosner;Teresa T. Fung;Susan E. Hankinson;Thomas W. Kensler;Walter C. Willett;Holly R. Harris
  • 通讯作者:
    Holly R. Harris
442: Fish Consumption and Prostate Cancer Recurrence - Health Professionals Follow-Up Study
  • DOI:
    10.1016/s0022-5347(18)37704-8
  • 发表时间:
    2004-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    June M. Chan;Crystal N. Holick;Michael F. Leitzmann;Meir J. Stampfer;Eric B. Rimm;Walter C. Willett;Edward Giovannucci
  • 通讯作者:
    Edward Giovannucci
Sugar-sweetened beverage consumption and weight gain in children and adults: a systematic review and meta-analysis of prospective cohort studies and randomized controlled trials
儿童和成人含糖饮料消费与体重增加:前瞻性队列研究和随机对照试验的系统综述和荟萃分析
  • DOI:
    10.1016/j.ajcnut.2022.11.008
  • 发表时间:
    2023-01-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Michelle Nguyen;Sarah E. Jarvis;Maria G. Tinajero;Jiayue Yu;Laura Chiavaroli;Sonia Blanco Mejia;Tauseef A. Khan;Deirdre K. Tobias;Walter C. Willett;Frank B. Hu;Anthony J. Hanley;Catherine S. Birken;John L. Sievenpiper;Vasanti S. Malik
  • 通讯作者:
    Vasanti S. Malik

Walter C. Willett的其他文献

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{{ truncateString('Walter C. Willett', 18)}}的其他基金

Life Course Cancer Epidemiology Cohort in Women
女性生命历程癌症流行病学队列
  • 批准号:
    8651432
  • 财政年份:
    2013
  • 资助金额:
    $ 625.13万
  • 项目类别:
Life Course Cancer Epidemiology Cohort in Women
女性生命历程癌症流行病学队列
  • 批准号:
    8513463
  • 财政年份:
    2013
  • 资助金额:
    $ 625.13万
  • 项目类别:
Life Course Cancer Epidemiology Cohort in Women
女性生命历程癌症流行病学队列
  • 批准号:
    9280875
  • 财政年份:
    2013
  • 资助金额:
    $ 625.13万
  • 项目类别:
Cancer Epidemiology Cohort in Male Health Professionals
男性健康专业人员中的癌症流行病学队列
  • 批准号:
    8534745
  • 财政年份:
    2012
  • 资助金额:
    $ 625.13万
  • 项目类别:
Cancer Epidemiology Cohort in Male Health Professionals
男性健康专业人员中的癌症流行病学队列
  • 批准号:
    8298342
  • 财政年份:
    2012
  • 资助金额:
    $ 625.13万
  • 项目类别:
Breast Cancer
乳腺癌
  • 批准号:
    7786693
  • 财政年份:
    2010
  • 资助金额:
    $ 625.13万
  • 项目类别:
Prospective Studies of Diet and Cancer in Men and Women
男性和女性饮食与癌症的前瞻性研究
  • 批准号:
    7929964
  • 财政年份:
    2009
  • 资助金额:
    $ 625.13万
  • 项目类别:
Cysteine, Related Gene Variants and Breast Cancer Risk
半胱氨酸、相关基因变异和乳腺癌风险
  • 批准号:
    7488799
  • 财政年份:
    2007
  • 资助金额:
    $ 625.13万
  • 项目类别:
Cysteine, Related Gene Variants and Breast Cancer Risk
半胱氨酸、相关基因变异和乳腺癌风险
  • 批准号:
    7666316
  • 财政年份:
    2007
  • 资助金额:
    $ 625.13万
  • 项目类别:
Cysteine, Related Gene Variants and Breast Cancer Risk
半胱氨酸、相关基因变异和乳腺癌风险
  • 批准号:
    7890406
  • 财政年份:
    2007
  • 资助金额:
    $ 625.13万
  • 项目类别:

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