Primary Prevention of Weight Gain for Women Aged 25-45

描述(由申请人提供) 这项研究将主要在巴西进行，作为美国国立卫生研究院的延伸 授予#R01 CA 50385和R01 HL60712-01。 超重(BMI(身体质量指数)25.0-29.9)和肥胖(BMI大于或 相当于30公斤/平方米)现在影响了超过40%的巴西成年人。女人 处于生育年龄的人特别容易肥胖，70%的人 在过去20年中，巴西观察到患病率有所上升。 脂肪摄入量的增加似乎无法解释这种趋势，而稳定的脂肪摄入量 整个国家的豆类消费量都出现了下降。许多 研究表明，血糖水平的变化是由于摄入了 特定的碳水化合物食物，用血糖指数(GI)衡量。一个 极低的血糖反应与豆类有关，而且它 有人建议，食用低GI饮食可以：1)减少饥饿/ 增加饱腹感；2)减少脂肪生成。在非随机化的随访中 参加肥胖治疗计划的儿童，儿童被分配到最低 GI饮食对BMI的下降幅度大于高GI组。没有很长的时间了 比较低体重减轻或预防体重增加的长期临床试验 有高GI饮食。然而，通过因子确定的饮食模式 在巴西里约热内卢市进行的一项调查中的分析表明， 主要是大米和豆类的摄入量与肥胖风险较低有关。这个 这项研究的目的是比较在巴西妇女中使用 鼓励他们吃两种不同的饮食模式(低GI和高GI)， 等量常量营养素组成，在18岁过程中控制体重 月份。低GI饮食模式将在很大程度上基于传统 大米和豆子的组合。对照组将被鼓励吃一种 饮食中含有相同数量的常量营养素，但更接近西方饮食。两者都有 节食是巴西人饮食的现实处方。具体地说， 这项研究将比较体重(主要结果)、食物摄入量、血液的变化 206名育龄成年妇女的化学成分和饥饿/饱腹感 体重指数为23-27公斤/平方米，在4周磨合后随机分为两种饮食之一 期间进食高GI饮食。

DESCRIPTION (provided by applicant) This research will be conducted primarily in Brazil as an extension of NIH grants # R0l CA 50385 and R0l HL60712-0l. Overweight (BMI (Body Mass Index) 25.0-29.9) and obesity (BMI greater than or equal to 30 kg/m2) now affect more than 40 percent of adult Brazilians. Women at reproductive age are particularly at risk of obesity and a 70 percent increase in the prevalence was observed in the last two decades in Brazil. Increasing fat intake does not appear to explain this trend, whereas a steady decline in the consumption of beans has been shown for the whole country. Many studies have demonstrated changes in blood glucose levels due to the intake of specific carbohydrate foods, as measured by glycemic index (GI). An exceptionally low blood glucose response was associated with beans and it has been suggested that the consumption of low-GI diets may: 1) decrease hunger/ increase satiation; 2) reduce lipogenesis. In a nonrandomized follow-up of children attending a program of obesity treatment, children assigned to a low GI diet had a decrease in BMI greater than the high GI group. There are no long term clinical trials of weight loss or prevention of weight gain comparing low with high GI diets. However, a dietary pattern identified through factor analysis in a survey in the city of Rio de Janeiro, Brazil, that represents mainly rice and bean intake was associated with lower risk of obesity. The purpose of this study is to compare in Brazilian women the effectiveness of encouraging them to eat two different dietary patterns (low vs. high GI), with equal macronutrient composition, on weight control over the course of 18 months. The low GI dietary pattern will be heavily based on the traditional rice and beans combination. The comparison group will be encouraged to eat a diet with the same amount of macronutrients, but closer to a Western diet. Both diets are realistic prescriptions of foods consumed by Brazilians.Specifically, this study will compare changes in weight (main outcome), food intake, blood chemistries and hunger/satiation in 206 adult women at reproductive age, with BMI of 23-27 kg/m2, randomized to either one of the diets after 4-week run-in period eating a high GI diet.