Cancer Epidemiology Cohort in Male Health Professionals

男性健康专业人员中的癌症流行病学队列

• 批准号: 8534745
• 负责人: Walter C. Willett
• 金额: $ 218.88万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-21 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8534745
• 关键词: Accounting; Age; Age-Years; Archives; Biological; Biological Markers; Blood; Blood specimen; Cancer Etiology; Cells; Cessation of life; Cohort Studies; Collaborations; Collection; Colon; Colonic Neoplasms; Colorectal; Colorectal Cancer; Colorectal Neoplasms; DNA; Data; Data Quality; Databases; Diagnosis; Diagnostic; Diet; Dietary Assessment; Dietary Component; Enrollment; Erythrocytes; Exposure to; Female; Food; Frequencies; Funding; Gene Expression; Genetic Predisposition to Disease; Germ Lines; Goals; Hand; Health Professional; Incidence; Laboratories; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Mediating; Medical; Medical Records; Messenger RNA; Methods; Morbidity - disease rate; Nail plate; Nurses' Health Study; Paper; Participant; Pathology; Pathology Report; Pharmaceutical Preparations; Phase; Physical activity; Plasma; Policies; Positioning Attribute; Procedures; Prostate; Prostatic Neoplasms; Publications; Publishing; Quality Control; Quality of life; Questionnaires; Recurrence; Reproducibility; Research Activity; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Risk; Risk Factors; Role; Sampling; Smoking; Structure of base of prostate; Structure of nail of toe; Support System; Survival Analysis; System; Systems Analysis; Time; TimeLine; Tissue Banks; Tissue Microarray; Tissues; Tumor Tissue; U-Series Cooperative Agreements; Update; Vitamin D; Weight; biobank; cancer diagnosis; cancer epidemiology; carcinogenesis; cohort; data management; data sharing; design; diet and cancer; evidence base; follow-up; genome wide methylation; indexing; male; male health; member; men; modifiable risk; mortality; novel; programs; tissue processing; tumor; validation studies

DESCRIPTION (provided by applicant): We propose to continue the follow-up of the Health Professional's Follow-up Study, a cancer epidemiology cohort of 51,529 men enrolled in 1986 when they were 40 to 75 years of age. The cohort is currently supported as part of a Program Project; consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The cohort includes a biorespository with DNA samples from 35,000 participants, plasma from 18,000, nails from 33,000, and tumor tissue from approximately 70% of incident colon, prostate, and other important cancers. In this cohort, smoking, weight, medication use, and medical diagnoses have been updated every 2 years and information on diet and physical activity has been updated every four years. Much other valuable exposure information is collected. Follow-up of the cohort has been approximately 94% complete at each of the 2-year follow-up cycles and ascertainment of deaths is at least 98% complete. This cohort has been highly productive; 341 papers have been published during the current funding cycle or are in press. Novel findings include the identification of modifiable risk factors that account for one third of aggressive prostate cancer; strong evidence based on plasma levels, germ line DNA, and gene expression in tumor tissue that vitamin D is importantly involved in risk of death from prostate cancer; and roles of specific diet factors and physical activity after the diagnosis f colorectal and prostate cancer in survival. This cohort has also contributed to 19 cancer-related consortia during this funding period and has an active data sharing component. The HPFS is unique as the largest cancer cohort in men with many repeated measures of exposure over more than two decades, which provides a powerful view of realistic latent periods for carcinogenesis and the opportunity to examine both pre-and post-diagnosis determinants of survival from cancer. Because of the massive, detailed data and biological samples already in hand, the nearly complete ascertainment of incident cancers with high rates of tissue acquisition, and the entry of the younger members of the cohort into the age of maximal cancer incidence, this cohort will be even more fruitful scientifically during the next five years.

描述（由申请人提供）：我们建议继续跟踪健康专业人员的随访研究，该研究是一个癌症流行病学队列，由 1986 年招募的 51,529 名 40 至 75 岁男性组成。该队列目前作为计划项目的一部分得到支持；根据NCI的政策，我们现在正在通过合作协议申请基础设施的支持。该队列包括一个生物储存库，其中包含 35,000 名参与者的 DNA 样本、18,000 名参与者的血浆、33,000 名参与者的指甲以及大约 70% 的结肠癌、前列腺癌和其他重要癌症的肿瘤组织。在这个队列中，吸烟、体重、药物使用和医疗诊断每两年更新一次，饮食和身体活动信息每四年更新一次。收集了许多其他有价值的暴露信息。在每个 2 年随访周期中，队列的随访完成率约为 94%，死亡确定至少完成 98%。这群人的生产力非常高；当前资助周期内已发表或正在出版的论文有 341 篇。新颖的发现包括确定可改变的风险因素，这些因素解释了 三分之一的侵袭性前列腺癌；基于血浆水平、种系 DNA 和肿瘤组织基因表达的有力证据表明，维生素 D 在前列腺癌死亡风险中发挥着重要作用；以及结直肠癌和前列腺癌诊断后特定饮食因素和体力活动对生存的影响。在此资助期间，该队列还为 19 个癌症相关联盟做出了贡献，并具有活跃的数据共享部分。 HPFS 是独一无二的，因为它是最大的男性癌症队列，在二十多年的时间里进行了多次重复的暴露测量，它提供了真实的致癌潜伏期的有力视角，并提供了检查癌症生存的诊断前和诊断后决定因素的机会。由于已经掌握了大量详细的数据和生物样本，几乎完全确定了高组织获取率的癌症发生率，并且队列中的年轻成员进入了癌症最高发病年龄，因此该队列在未来五年将在科学上更加富有成效。