Life Course Cancer Epidemiology Cohort in Women

女性生命历程癌症流行病学队列

• 批准号: 8651432
• 负责人: Walter C. Willett
• 金额: $ 336.11万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8651432
• 关键词: Accounting; Age; Age-Years; Archives; Benign; Biological Markers; Biopsy; Blood; Breast Diseases; Cells; Cessation of life; Cheek structure; Collaborations; Collection; Colon Carcinoma; Colorectal Adenoma; Computer Systems; DNA; DNA Methylation; Data; Data Quality; Databases; Development; Diagnosis; Diagnostic; Diet; Dimensions; Enrollment; Epidemiology; Erythrocytes; Exposure to; Feasibility Studies; Feces; Gene Expression; Genetic Predisposition to Disease; Genetic Transcription; Goals; Incidence; Infant; Laboratories; Lesion; Leukocytes; Life Cycle Stages; Life Style; Link; Malignant Neoplasms; Malignant neoplasm of ovary; Mammary Neoplasms; Mammography; Measurement; Measures; Mediating; Medical; Menopause; Messenger RNA; Methods; Mothers; Nurses' Health Study; Paper; Participant; Pathology; Perinatal Exposure; Persons; Pharmaceutical Preparations; Phase; Physical activity; Plasma; Policies; Postmenopause; Premenopause; Publications; Publishing; Quality Control; Questionnaires; Reproducibility; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Retrieval; Risk Factors; Sampling; Smoking; System; Time; Tissue Banks; Tissue Microarray; Tissues; Translational Research; Tumor Tissue; U-Series Cooperative Agreements; Update; Urine; Validation; Weight; Woman; biobank; breast density; breast lesion; cancer epidemiology; carcinogenesis; case control; cohort; data management; diet and cancer; follow-up; genetic analysis; genome wide methylation; high school; in utero; indexing; malignant breast neoplasm; melanoma; member; microbiome; mortality; new technology; novel; screening; software development; tumor

DESCRIPTION (provided by applicant): We propose to continue the follow-up of the Nurses' Health Study II, a cancer epidemiology cohort of 116,430 women enrolled at ages 25 to 42 years in 1989. The cohort is currently supported as an R0I. Consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The NHSII biorepository includes plasma, red blood cells, white blood cells, and first morning urine samples from 29,611 women; for two thirds of these women we have timed follicular and luteal premenopausal samples. Over 16,000 provided a 2nd blood/urine sample in 2008-11 when the majorities were postmenopausal, and we have cheek cell DNA from an additional 29,859 women. We have collected archival tissue blocks for incident breast and ovarian cancers and melanoma (approximately 70% of requested have been obtained). We have created tissue microarrays for breast cancers that are already being used extensively. Prediagnostic mammograms have been collected for breast cancer cases and controls, as well as pathology material from previous biopsies of benign lesions. The follow-up of the NHSII cohort, conducted every two years, has been high and accounts for 93% of potential person-time. We have nearly complete ascertainment of deaths using the National Death Index and other methods. The NHSII cohort is unique in many ways, as the only large cohort of women enrolled before menopause, with information on smoking, weight, medication use, and medical diagnoses updated every 2 years and information on diet and physical activity updated every four years. Further, we have collected detailed on in utero and infant exposures (from participants' mothers), diet during high school, and other valuable exposure information. This cohort has been highly productive; over 150 papers have been published during the last five years, and the rate of publication is increasingly rapidly. This cohort is a member of the NCI Cohort Consortium, has participated in many collaborative studies, and has an active resource-sharing component. Enhancements of the cohort infrastructure involve assessment of breast tumor DNA methylation and RNA expression and the gut microbiome, and development of software to account for measurement error.

描述(申请人提供)：我们建议继续跟进护士健康研究II，这是一项癌症流行病学队列研究，在1989年登记了116,430名年龄在25岁至42岁之间的女性。该队列目前被支持为R0I。与NCI的政策一致，我们现在正在通过合作协议申请基础设施的支持。NHSII生物资料库包括来自29,611名妇女的血浆、红细胞、白细胞和第一次晨尿样本；对于其中三分之二的妇女，我们对绝经前的卵泡和黄体样本进行了计时。在2008-11年间，超过16,000人提供了第二次血/尿样本，当时大多数人是绝经后的，我们从另外29,859名女性身上提取了脸颊细胞DNA。我们已经收集了乳腺癌、卵巢癌和黑色素瘤的档案组织块(大约70%的要求已经获得)。我们已经为乳腺癌创建了组织微阵列，这些微阵列已经被广泛使用。已经收集了乳腺癌病例和对照的诊断前乳房X光照片，以及以前良性病变活检的病理材料。每两年进行一次的NHSII队列随访一直很高，占潜在人次的93%。我们已经使用国家死亡指数和其他方法几乎完全确定了死亡人数。NHSII的队列在许多方面都是独一无二的，因为它是绝经前登记的唯一一大批女性，关于吸烟、体重、用药和医疗诊断的信息每两年更新一次，关于饮食和体力活动的信息每四年更新一次。此外，我们还收集了详细的子宫和婴儿暴露(来自参与者的母亲)、高中期间的饮食和其他有价值的暴露信息。这一群体卓有成效；在过去五年中发表了150多篇论文，而且发表的速度越来越快。这个队列是NCI队列联盟的成员，参与了许多合作研究，并有一个积极的资源共享部分。队列基础设施的增强包括评估乳腺肿瘤DNA甲基化和RNA表达以及肠道微生物组，以及开发软件来解决测量误差。