SCIENTIFIC DEVELOPMENT OF A NEW EVOKED-RESPONSE METHOD

我们最近开发了一种新的诱发反应研究分析技术，该技术表明，被称为“听觉诱发40赫兹反应”的“稳态”反应实际上是由一系列重叠的瞬态诱发反应组成的，以前没有在人类或动物中记录过。这些被唤起的反应，我们称之为“g波”，具有潜在的意义，因为它们可能与皮层功能中的感知“结合”机制以及感知的某些方面有关。本应用程序描述了一个研究揭示这些波的方法的项目，以确保获得的波形是有效的。我们亦会研究“增白”降噪的效果。这项基础研究与人类健康有关，因为它涉及到一种监测大脑功能的新手段，这反过来又有助于了解大脑功能障碍，特别是在皮层生理学和感觉活动方面。录音技术使用非侵入性的头皮录音。这使得研究结果适用于心理生理学实验，以及临床试验。

We have recently developed a new analysis technique for evoked- response research that has shown that the "steady-state" response called the "auditory-evoked 40-Hz response" is actually made up of a series of overlapping transient evoked-responses, not previously recorded in humans or animals. These evoked responses, which we call "G-waves", have potential significance because of the possibility that they are related to mechanisms of perceptual "binding" in cortical function, as well as to some aspects of perception. This application describes a project to study the method that reveals these waves, so as to ensure that the obtained waveforms are valid. We will also study the effects of noise reduction using "whitening". This basic research has relevance to human health because it involves a new means to monitor the functioning of the brain, which in turn could help in understanding brain dysfunctions, especially as regards to cortical physiology and sensory activity. The recording techniques use non-invasive, scalp recordings. This makes the findings applicable to psychophysiological experiments, as well as to clinical tests.