Improved head model for dipole analysis in children

描述(由申请人提供)： 偶极子源定位(DSL)是一种常用的分析技术，它使用迭代的计算机搜索算法在数学模型中寻找能够解释给定诱发反应的偶极子。DSL的结果缺乏任何直接的准确性证据。由于模型中的参数不准确，我们有充分的理由期待不准确的结果。其中一个不准确的地方是头骨和头皮的电阻率。婴儿的问题更严重，因为头骨的电阻率必须随着头盖骨的钙化而改变。申请人模拟了一种估计关键DSL模型参数的方法，知道不准确的模型可以变得准确。拟议的项目将在婴儿和儿童身上测试这种方法，使用记录的诱发反应。准确度的“黄金标准”将基于相同受试者的核磁共振成像记录。

DESCRIPTION (provided by applicant): DSL (Dipole-Source Localization) is a commonly used analysis technique in which an iterative computer search algorithm in a mathematical model is used to find dipoles that can explain a given evoked-response. DSL results lack any direct proof of accuracy. There are good reasons to expect inaccurate results, due to inaccurate parameters in the model. One of the inaccuracies concerns skull and scalp resistivities. The problem is worse with infants because the skull resistivity must change as the calvarium calcifies. The applicant has simulated a method of estimating critical DSL model parameters, knowing that an inaccurate model can be made accurate. The proposed project will test this method in infants and children, using recorded evoked responses. The "gold standard" for accuracy will be based on MRI recordings from the same subjects.