Error Reduction in Dipole-Source Localization Models

偶极子源定位模型中的误差减少

• 批准号: 7097904
• 负责人: Don L. Jewett
• 金额: $ 39.22万
• 依托单位: ABRATECH CORPORATION
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7097904
• 关键词: auditory stimulus; bioimaging /biomedical imaging; clinical research; computational neuroscience; computer simulation; dipole moment; electroencephalography; evoked potentials; human subject; longitudinal human study; magnetic resonance imaging; method development; model design /development; physical model

DESCRIPTION (provided by applicant): We are developing means to reduce errors in Dipole Source Localization (DSL). DSL is commonly used to analyze brain waves for clinical and research purposes. It is known from our work and the work of others that the models used to compute the DSL are not perfect, but it is not known how much the imperfect models affect the solutions obtained. Based upon our prior work, and some new concepts, we have developed the DSME (Dipole-Source Model- Error). We have tested its efficacy in spheres, and will do so in headshape models in this project. We will compare errors both by simulations, and also by determining whether the DSL has errors when analyzing evoked-responses from known neural generators. The health-related aspects include the clinical uses of evoked-responses and DSL, and the fact that improvements in the accuracy of the technique will improve these uses.

描述（由申请人提供）：