EVOKED POTENTIAL G-WAVE DETECTION FOR SLEEP ANALYSIS

这项研究的目标是开发一种创新的方法，使用听觉诱发反应作为觉醒状态、睡眠深度和睡眠障碍中的重要因素的衡量标准。这项新方法利用比平时更高的刺激率来记录人类头皮的G波，并将其与EEG、EOG和EMG电极记录的标准睡眠深度测量进行比较。由于我们的第一阶段研究表明G波受睡眠的影响，而且G波提供了大脑活动的新指标，这里提出的研究将确定这些新指标的变化与标准睡眠指标变化的相关性。其他研究将寻找最佳刺激和刺激参数。G波可能为临床医生诊断和治疗睡眠障碍患者提供一种新的工具。

The goal of this research is to develop an innovative new method of using auditory evoked responses as a measure of state of arousal, of depth of sleep, and of factors of importance in sleep disorders. The new method, utilizing higher-than-usual stimulation rates to record G-waves from the scalps of humans; will be compared with standard measures of depth of sleep recorded from EEG, EOG, and EMG electrodes. Since our Phase I studies suggest that G-waves are affected by sleep, and since G-waves provide new measures of brain activity, the research proposed here will determine the correlations of changes in these new measures with changes in standard measures of sleep. Other studies will look for optimum stimulus and stimulation parameters. G-waves may provide a new tool for clinicians who are diagnosing and treating patients with sleep disorders.