ABR train-block detection of small acoustic neuromas

小听神经瘤的 ABR 列车块检测

• 批准号: 6584503
• 负责人: Don L. Jewett
• 金额: $ 10万
• 依托单位: ABRATECH CORPORATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-06 至 2006-08-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6584503
• 关键词: acoustic nerve; brain stem; clinical research; diagnosis design /evaluation; ear /hearing prosthesis; ear disorder diagnosis; electrophysiology; evoked potentials; human subject; magnetic resonance imaging; neoplasm /cancer diagnosis; nerve sheath neoplasm; nervous system neoplasms; neural conduction; neural inhibition

DESCRIPTION (provided by applicant): The evoked response called the ABR (Auditory Brainstem Response) is affected by nerve compression by acoustic neuromas, but is not presently sensitive enough to detect small tumors. If the ABR could be used to detect tumors, it would reduce overall medical costs and also provide a means to judge rate of tumor progression. This project proposes to improve the sensitivity of the ABR to nerve compression by acoustic neuromas by two means: 1) using a new chirp-stimulus recently published, which provides stimulation of all VIIIth nerve fibers, including those subserving low-frequencies. 2) stimulating at very high stimulus repetition-rates. A new method has been developed by Abratech Corporation which permits recording the ABR at the high stimulus repetition-rates likely to be needed for detection of small tumors. The research proposed will test the sensitivity of the new method combined with the new chirp-stimulus, in patients who have small acoustic neuromas. This proposal is health-related because it is directed towards a known health-problem: the diagnosis and monitoring of acoustic neuromas.

描述(申请人提供)：被称为ABR(听性脑干反应)的诱发反应受到听神经瘤的神经压迫的影响，但目前还不够敏感，无法检测出小肿瘤。如果ABR能够用于检测肿瘤，它将降低总体医疗成本，并提供一种判断肿瘤进展速度的手段。本项目建议通过两种方法提高ABR对听神经瘤压迫神经的敏感性：1)使用最近发表的一种新的啁啾刺激，它提供对所有VIIIth神经纤维的刺激，包括那些从属于低频的神经纤维。2)以很高的刺激重复率刺激。Abratech公司开发了一种新方法，可以在检测小肿瘤可能需要的高刺激重复率下记录ABR。提出的这项研究将在患有小型听神经瘤的患者中测试新方法与新的啁啾刺激相结合的敏感性。这项建议与健康有关，因为它针对的是一个已知的健康问题：听神经瘤的诊断和监测。