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REGULATION OF CORNEAL WOUND HEALING IN TYPE I DIABETES

REGULATION OF CORNEAL WOUND HEALING IN TYPE I DIABETES
I 型糖尿病角膜伤口愈合的调节
批准号:
6207738
负责人:
IAN S ZAGON
金额:
$3.88万
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-09-30 至 2001-09-29

项目摘要

项目成果

IAN S ZAGON的其他基金

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中文摘要
翻译
描述:(改编自申请人的摘要)三个描述
英文摘要
DESCRIPTION: (Adapted from the applicant's abstract) The three described specific aims and approach to their accomplishment in this proposal are: 1) to determine the importance of opioid-receptor interaction on homeostatic cellular renewal of the diabetic corneal epithelium by studying OGF/receptor expression and the effects of excess OGF or blockade of OGF activity with naltrexone on DNA synthesis in diabetic rat corneal epithelium limbus and conjunctiva; 2) to define the role of an endogenous opioid system related to growth in the re-epithelialization of denuded corneal epithelium in diabetic rats by examining healing and integrity of the repaired epithelium after systemic and topical treatment with naltrexone of rats subjected to corneal abrasions; and 3) to ascertain the influence of an endogenous opioid system related to growth in the repair of corneal wound healing by studying the effect of opioid receptor blockade on healing of wounded epithelium in human corneas in organ culture.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Naltrexone, an opioid antagonist, facilitates reepithelialization of the cornea in diabetic rat.
纳曲酮是一种阿片类拮抗剂,可促进糖尿病大鼠的角膜上皮再生。
DOI: 10.2337/diabetes.51.10.3055
发表时间: 2002
期刊: Diabetes
影响因子: 7.7
作者: [Zagon,IanS, Jenkins,JoeB, Sassani,JosephW, Wylie,JamesD, Ruth,TorreB, Fry,JamieL, Lang,CMax, McLaughlin,PatriciaJ]
通讯作者: McLaughlin,PatriciaJ
OGF-OGFr Axis Modulation to Prevent Diabetic Ocular Surface Complications.
OGF-OGFr Axis Modulation to Prevent Diabetic Ocular Surface Complications.
Naltrexone as a Novel Treatment for Diabetic Keratopathy
Naltrexone as a Novel Treatment for Diabetic Keratopathy
海外基金