课题基金 / 基金详情

REGULATION OF CORNEAL WOUND HEALING IN TYPE I DIABETES

REGULATION OF CORNEAL WOUND HEALING IN TYPE I DIABETES
I 型糖尿病角膜伤口愈合的调节
批准号：
6053409
负责人：
IAN S ZAGON
金额：
$13.51万
依托单位：
PENNSYLVANIA STATE UNIV HERSHEY MED CTR
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-09-30 至 2001-09-29
来源：
https://reporter.nih.gov/project-details/6053409
关键词：
clinical research cornea corneal epithelium eye regeneration growth factor human subject immunocytochemistry in situ hybridization insulin dependent diabetes mellitus laboratory rat opioid receptor receptor expression tissue /cell culture wound healing

项目摘要

项目成果

IAN S ZAGON的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION: (Adapted from the applicant's abstract) The three described specific aims and approach to their accomplishment in this proposal are: 1) to determine the importance of opioid-receptor interaction on homeostatic cellular renewal of the diabetic corneal epithelium by studying OGF/receptor expression and the effects of excess OGF or blockade of OGF activity with naltrexone on DNA synthesis in diabetic rat corneal epithelium limbus and conjunctiva; 2) to define the role of an endogenous opioid system related to growth in the re-epithelialization of denuded corneal epithelium in diabetic rats by examining healing and integrity of the repaired epithelium after systemic and topical treatment with naltrexone of rats subjected to corneal abrasions; and 3) to ascertain the influence of an endogenous opioid system related to growth in the repair of corneal wound healing by studying the effect of opioid receptor blockade on healing of wounded epithelium in human corneas in organ culture.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
OGF-OGFr Axis Modulation to Prevent Diabetic Ocular Surface Complications.
OGF-OGFr Axis Modulation to Prevent Diabetic Ocular Surface Complications.
Naltrexone as a Novel Treatment for Diabetic Keratopathy
Naltrexone as a Novel Treatment for Diabetic Keratopathy
海外基金