Does the fruitless gene influence species-specific variation in mating behaviour?

无结果基因是否会影响交配行为的物种特异性变异？

• 批准号: NE/J020818/1
• 负责人: Michael Ritchie
• 金额: $ 42.27万
• 依托单位: University of St Andrews
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FJ020818%2F1
• 关键词: Does; fruitless; gene; influence; species

Genes responsible for variation in species-specific mating signals may be important to speciation and biodiversity because evolutionary divergence in these loci can play a role in promoting sexual isolation and decreasing gene flow between natural populations of diverging species. Identifying and studying the divergence of such genes is a key priority of contemporary evolutionary genetics. In a series of QTL studies of divergence of song traits between and within species of the fruit fly Drosophila, the gene fruitless (fru) has been implicated in the control of variation in this classic trait. Much is known about the structure and function of this gene in controlling song production in D. melanogaster, but little if anything about its role in influencing natural variation in song. We propose a) developing a combination of advanced 'gene swap' techniques to move exons of the gene from a range of species into D. melanogaster b) studies of the molecular evolution of fru within and between natural populations and species c) association analysis of variation in fru and traits in natural populations and d) examination of the evolution of regulatory regions to assess in detail the role of fru in natural variation at multiple levels. This will represent a uniquely detailed examination of the evolution of a candidate locus for a complex behavioural trait.

负责物种特异性交配信号变异的基因可能对物种形成和生物多样性很重要，因为这些基因座的进化分歧可以在促进性隔离和减少不同物种自然种群之间的基因流动方面发挥作用。识别和研究这些基因的差异是当代进化遗传学的首要任务。在一系列关于果蝇物种之间和内部鸣叫性状差异的 QTL 研究中，无果基因 (fru) 与控制这一经典性状的变异有关。人们对这个基因控制黑腹果蝇鸣叫产生的结构和功能了解很多，但对其影响鸣叫自然变异的作用却知之甚少。我们建议 a) 开发先进的“基因交换”技术组合，将基因的外显子从一系列物种转移到黑腹果蝇中 b) 研究自然种群和物种内部以及自然种群和物种之间的 fru 分子进化 c) fru 变异和自然种群性状的关联分析 d) 检查调控区域的进化，以详细评估 fru 在多个层面的自然变异中的作用。这将代表对复杂行为特征候选基因座进化的独特详细检查。

项目成果

Inter- and intra-specific genomic divergence in Drosophila montana shows evidence for cold adaptation

果蝇蒙大拿州的种间和种内基因组差异显示了冷适应的证据

• DOI: 10.1101/282582
• 发表时间: 2018
• 作者: Parker D

The evolution of novelty in conserved genes; evidence of positive selection in the Drosophila fruitless gene is localised to alternatively spliced exons.

保守基因的新颖性的进化；

• DOI: 10.1038/hdy.2013.106
• 发表时间: 2014
• 期刊: Heredity
• 影响因子: 3.8
• 作者: Parker DJ

Postmating-prezygotic isolation between two allopatric populations of Drosophila montana: fertilisation success differs under sperm competition.

• DOI: 10.1002/ece3.1995
• 发表时间: 2016-03
• 期刊: Ecology and evolution
• 影响因子: 2.6
• 作者: Ala-Honkola O;Ritchie MG;Veltsos P
• 通讯作者: Veltsos P

Bringing bioinformatics to schools with the 4273pi project.

• DOI: 10.1371/journal.pcbi.1009705
• 发表时间: 2022-01
• 期刊: PLoS computational biology
• 影响因子: 4.3
• 作者: Bain SA;Plaisier H;Anderson F;Cook N;Crouch K;Meagher TR;Ritchie MG;Wallace EWJ;Barker D
• 通讯作者: Barker D

Male-specific fruitless isoforms target neurodevelopmental genes to specify a sexually dimorphic nervous system.

• DOI: 10.1016/j.cub.2013.11.035
• 发表时间: 2014-02-03
• 期刊: CURRENT BIOLOGY
• 影响因子: 9.2
• 作者: Neville, Megan C.;Nojima, Tetsuya;Ashley, Elizabeth;Parker, Darren J.;Walker, John;Southall, Tony;Van de Sande, Bram;Marques, Ana C.;Fischer, Bettina;Brand, Andrea H.;Russell, Steven;Ritchie, Michael G.;Aerts, Stein;Goodwin, Stephen F.
• 通讯作者: Goodwin, Stephen F.