Identifying the genetic targets of sexual selection

确定性选择的遗传目标

• 批准号: NE/V001566/1
• 负责人: Michael Ritchie
• 金额: $ 63.42万
• 依托单位: University of St Andrews
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FV001566%2F1
• 关键词: Identifying; genetic; targets; sexual; selection

Sexual selection influences genomic divergence, for example genes which show sex-biased gene expression are often the most divergent between species. This is sometimes more pronounced in sexually dimorphic species and is therefore thought to reflect the strength of sexual selection. Currently different (even contrasting) patterns of genomic divergence can be interpreted as supporting an influence of sexual selection and conflict on genomic divergence. The resolution and reliability of such patterns is highly debated and unclear. Identifying the precise targets of sexual selection and the signature this leaves in the genome is critical to understanding the importance of this form of selection in evolutionary divergence and speciation. The proposed work will provide an exceptional contribution to resolving how sexual selection acts on genotypes, by leveraging an experimental evolution study which has identified several candidate genes. We will complete functional genetic analyses to confirm the role of these genes and measure the fitness consequences of gene knock outs. We will then upscale this to natural populations and assess the performance of genomic signatures of divergence in natural populations from a range of ecological contexts and levels of evolutionary divergence. This work will provide unprecedented insight into the role of sexual selection in genomic divergence.

性选择影响基因组分化，例如，表现出性别偏向基因表达的基因通常是物种之间最分化的基因。这在性二型物种中有时更为明显，因此被认为反映了性选择的强度。目前不同的（甚至是对比）模式的基因组分歧可以解释为支持性选择和冲突的影响基因组分歧。这种模式的分辨率和可靠性是高度争议和不明确的。确定性选择的精确目标以及它在基因组中留下的签名对于理解这种形式的选择在进化分歧和物种形成中的重要性至关重要。拟议的工作将提供一个特殊的贡献，解决性选择如何作用于基因型，通过利用实验进化研究，其中已确定了几个候选基因。我们将完成功能遗传分析，以确认这些基因的作用，并衡量基因敲除的适应性后果。然后，我们将扩大到自然种群，并评估自然种群中的基因组签名的分歧，从一系列的生态环境和进化分歧的水平的性能。这项工作将为性选择在基因组分化中的作用提供前所未有的见解。

项目成果

Selection on the Fly: Short-Term Adaptation to an Altered Sexual Selection Regime in Drosophila pseudoobscura.

• DOI: 10.1093/gbe/evad113
• 发表时间: 2023-07-03
• 期刊: GENOME BIOLOGY AND EVOLUTION
• 影响因子: 3.3
• 作者: Barata, Carolina;Snook, Rhonda R.;Ritchie, Michael G.;Kosiol, Carolin
• 通讯作者: Kosiol, Carolin