COMPUTER MODELLING OF PROPAGATION IN THE HEART

心脏传播的计算机模型

• 批准号: 2794959
• 负责人: JACQUES BEAUMONT
• 金额: $ 39.66万
• 依托单位: UPSTATE MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-15 至 2000-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2794959
• 关键词: action potentials; biomedical equipment; biomedical equipment purchase; computer network; computer program /software; computer simulation; computers; heart electrical activity; parallel processing

This proposal requests support to purchase equipment (a central computational unit) that will be used to fulfill the computer modeling, data processing and data analysis needs of 7 independent investigators working the Departments of Pharmacology, Microbiology and Medicine at the SUNY Health Science Center in Syracuse, NY. The program represents a multidisciplinary approach whose overall objective is to achieve an understanding of normal and abnormal electrical wave propagation in cardiac muscle. Our efforts are directed toward elucidating the underlying two- and three-dimensional dynamics of wave propagation in the heart and the mechanisms of reentrant ventricular tachyarrhythmias, as well as the structure-function relations that determine gating behavior of the major cardiac gap junction (Cx43) protein and of a delayed rectifier potassium channel (HERG) which as been cloned from human tissue. The central theme, "Intercellular Communication and Impulse Propagation", addresses an important scientific topic of clinical relevance, and allows the unique opportunity of bringing together a group of investigators, experts in various relevant fields, including cellular electrophysiology, biophysics, biomedical engineering, mathematics, computer science and molecular biology, in a productive cooperative research program. Major support of this program comes from a Program Project Grant (PO1 HL39707) from the National Heart Lung and Blood Institute. Support is provided also by the American Heart Association and the North American Society of Pacing and Electrophysiology. In addition, funding is pending from the Whitaker Foundation, as well as from NIH in the form of RO1 grant of two of our investigators. Continuous finding of our research group since 1982 has been exceedingly fruitful. For example, over the last 5 years we have published 85 peer-review papers and have contributed significantly to the understanding of fundamental mechanisms of intercellular communication and impulse propagation. A major strength of our group is its ability to successfully complement experimental studies on the cellular mechanisms of propagation of electrical impulses under normal and abnormal conditions with computer modeling studies aimed at predicting heart tissue behaviors. Computer models are an essential tool to formulate hypotheses regarding ionic mechanisms, and propagation dynamics of the genesis of cardiac arrhythmias. It is our goal to continue using such a combined experimental-computer modeling approach in our future studies.

该提案要求支持购买设备（中央计算单元），用于满足在纽约州锡拉丘兹SUNY健康科学中心药理学、微生物学和医学系工作的7名独立研究者的计算机建模、数据处理和数据分析需求。 该计划代表了一个多学科的方法，其总体目标是实现正常和异常电波在心肌中传播的理解。 我们的努力是针对阐明潜在的二维和三维动力学的波在心脏中的传播和折返性室性快速性心律失常的机制，以及结构-功能关系，决定门控行为的主要心脏间隙连接（Cx43）蛋白和延迟整流钾通道（HERG），从人体组织中克隆。 中心主题，“细胞间通讯和脉冲传播”，解决了临床相关的重要科学课题，并允许汇集一组研究人员，在各个相关领域的专家，包括细胞电生理学，生物物理学，生物医学工程，数学，计算机科学和分子生物学，在一个富有成效的合作研究计划的独特机会。 该计划的主要支持来自国家心肺和血液研究所的计划项目赠款（PO 1 HL 39707）。 美国心脏协会和北美起搏和电生理学会也提供支持。 此外，惠特克基金会以及NIH正在等待资金，我们的两名研究人员将以RO 1赠款的形式获得资金。 自1982年以来，我们的研究小组不断进行发现，取得了丰硕的成果。 例如，在过去的5年中，我们发表了85篇同行评议论文，并为理解细胞间通信和脉冲传播的基本机制做出了重大贡献。 我们小组的一个主要优势是能够成功地补充实验研究的细胞机制的传播电脉冲在正常和异常条件下与计算机建模研究，旨在预测心脏组织的行为。 计算机模型是一个必不可少的工具，制定关于离子机制的假设，和传播动力学的起源心律失常。 我们的目标是在我们未来的研究中继续使用这种结合实验-计算机建模的方法。

项目成果

Induction of antibodies against prostate-specific membrane antigen (PSMA) by vaccination with a PSMA DNA vector.

通过接种 PSMA DNA 载体来诱导针对前列腺特异性膜抗原 (PSMA) 的抗体。

• DOI: 10.1016/s0302-2838(02)00211-7
• 发表时间: 2002
• 期刊: European urology
• 影响因子: 23.4
• 作者: Kuratsukuri,Katsuyuki;Wang,ChingY;Sone,Tomomichi;Nishisaka,Nobuyasu;Jones,RichardF;Haas,GabrielP
• 通讯作者: Haas,GabrielP

Differential gene expression in human prostate cancer cells adapted to growth in bone in Beige mice.

人类前列腺癌细胞适应米色小鼠骨骼生长的差异基因表达。

• DOI: 10.1016/s1078-1439(02)00202-8
• 发表时间: 2003
• 期刊: Urologic oncology
• 作者: Soos,Gyorgyike;Haas,GabrielP;Wang,ChingY;Jones,RichardF
• 通讯作者: Jones,RichardF