SIMULATIONS OF VORTICES OF EXCITATION WAVES IN CARDIAC TISSUE

心肌组织中激励波涡流的模拟

• 批准号: 6309537
• 负责人: JACQUES BEAUMONT
• 金额: $ 2.43万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6309537
• 关键词: biomedical resource; cardiovascular system; computers; model design /development; technology /technique

In this project, we aim at improving a model devised to simulate the generation and transmission of electrical impulses by cardiac cells. This model is used to study the mechanisms of initiation and sustainment of vortices of excitation waves which underlie cardiac tachyarrhythmias. In a subsequent phase, and if the model can realistically reproduce vortices of excitation, we will study how membrane functions can be altered to terminate such vortices. We have developed a parallel version of our code using MPI. Based on our performance tests, using 32 processors on the IBM SP, it will take 10 hours (wall clock) to obtain an episode of tachycardia; i.e. 1 sec of vortex-like activity, in a small piece of cardiac tissue of 2 cm x 2 cm. The same simulation requires a little more than 8 days on a SPARC 10 model 512. During the period of support, we will improve the matrix inversion procedure of the current version. We believe that it is possible to divide the computation time by a factor ranging between 3 and 5 by using a preconditioning procedure suitable for parallelization

在这个项目中，我们的目标是改进一个模型， 心脏电脉冲的产生和传递 细胞 该模型被用来研究引发机理， 维持心源性兴奋波的涡流 心律失常 在随后的阶段，如果模型能够 真实再现涡流的激励，我们将研究如何 可以改变膜功能以终止这种涡旋。 我们有 用MPI开发了我们代码的并行版本。 基于我们 性能测试，使用IBM SP上的32个处理器，将需要10 小时（挂钟）获得心动过速发作;即1秒 漩涡样活动，在一小块2 cm x 2的心脏组织中 厘米 同样的模拟需要8天多一点的时间， 10个512型。 在支持期间，我们将改进 矩阵求逆程序的当前版本. 我们认为 可以将计算时间除以范围在 3和5，使用适用于 并行化