PROTON NMR SPECTROSCOPY OF HUMAN FOCAL EPILEPSY AT 4 IT

已知心肌梗死区域的存在 可能会导致致命的心律失常，很少或根本没有警告。这 该项目寻求将脑梗塞的三维构型联系起来 突然出现心律失常。这将在开始时使用 高分辨率(0.2-0.3 mm空间分辨率)各向同性三维核磁共振 固定人心脏的高场成像。高场成像将 允许采集具有足够信噪比的图像，同时 保持非常高的空间分辨率。最初的实验已经 展示了清楚地显示脑梗塞区域的能力 使用T1的固定心脏(福尔马林)的正常组织 加权核磁共振成像。这项研究可能会导致高分辨率 起搏心肌梗死动物模型的心功能显像 在核心项目III下开发的成像技术(成像 生理功能)。

It is known that the presence of infarcted regions of myocardium can result in fatal arrhythmias with little or no warning. This project seeks to correlate the 3-dimensional configuration of infarcts with onset of sudden arrhythmia. This will be done initially using high-resolution (0.2-0.3mm spatial resolution) isotropic 3D NMR imaging at high field of fixed human hearts. High field imaging will permit acquisition of images with adequate signal-to-noise ratio while maintaining very high spatial resolution. Initial experiments have demonstrated the ability to clearly visualize infarcted regions within (what had been) normal tissue of fixed hearts (formalin) using T1 weighted NMR imaging. This study may lead to high resolution ventricular function imaging of paced infarct animal models using imaging techniques developed under Core Project III (Imaging of Physiological Function).