PROTON NMR SPECTROSCOPY OF HUMAN FOCAL EPILEPSY AT 4 IT

已知心肌梗塞区域的存在 可能会在很少或没有任何警告的情况下导致致命的心律失常。 这个 该项目旨在关联梗塞的 3 维结构 突发心律失常发作。 这最初将使用 高分辨率（0.2-0.3mm空间分辨率）各向同性3D NMR 固定人类心脏的高场成像。 高场成像将 允许采集具有足够信噪比的图像，同时 保持非常高的空间分辨率。 初步实验有 展示了清晰可视化内梗塞区域的能力 使用 T1 固定心脏（福尔马林）的（曾经的）正常组织 加权核磁共振成像。 这项研究可能会带来高分辨率 起搏梗死动物模型的心室功能成像 核心项目 III 下开发的成像技术（成像 生理功能）。

It is known that the presence of infarcted regions of myocardium can result in fatal arrhythmias with little or no warning. This project seeks to correlate the 3-dimensional configuration of infarcts with onset of sudden arrhythmia. This will be done initially using high-resolution (0.2-0.3mm spatial resolution) isotropic 3D NMR imaging at high field of fixed human hearts. High field imaging will permit acquisition of images with adequate signal-to-noise ratio while maintaining very high spatial resolution. Initial experiments have demonstrated the ability to clearly visualize infarcted regions within (what had been) normal tissue of fixed hearts (formalin) using T1 weighted NMR imaging. This study may lead to high resolution ventricular function imaging of paced infarct animal models using imaging techniques developed under Core Project III (Imaging of Physiological Function).