PROTON NMR SPECTROSCOPY OF HUMAN FOCAL EPILEPSY AT 4 IT

人类局灶性癫痫的质子核磁共振波谱 4 IT

• 批准号: 6480912
• 负责人: RUBEN I KUZNIECKY
• 金额: $ 15.58万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6480912
• 关键词: bioengineering /biomedical engineering; biomedical resource; cardiovascular system; computers; nervous system; nuclear magnetic resonance spectroscopy; technology /technique

It is known that the presence of infarcted regions of myocardium can result in fatal arrhythmias with little or no warning. This project seeks to correlate the 3-dimensional configuration of infarcts with onset of sudden arrhythmia. This will be done initially using high-resolution (0.2-0.3mm spatial resolution) isotropic 3D NMR imaging at high field of fixed human hearts. High field imaging will permit acquisition of images with adequate signal-to-noise ratio while maintaining very high spatial resolution. Initial experiments have demonstrated the ability to clearly visualize infarcted regions within (what had been) normal tissue of fixed hearts (formalin) using T1 weighted NMR imaging. This study may lead to high resolution ventricular function imaging of paced infarct animal models using imaging techniques developed under Core Project III (Imaging of Physiological Function).

众所周知，心肌梗塞区域的存在 可能会导致致命的心律失常，而很少或没有警告。 这 一个项目试图将梗塞的三维结构 突发心律失常 这将首先使用 高分辨率（0.2-0.3mm空间分辨率）各向同性3D NMR 在固定的人类心脏的高场成像。 高场成像将 允许采集具有足够信噪比的图像， 保持很高的空间分辨率。 最初的实验 证明了能够清楚地可视化梗塞区域内， (what已）正常组织的固定心脏（福尔马林），使用T1 加权核磁共振成像 这项研究可能会导致高分辨率 起搏心肌梗死动物模型的心室功能显像 核心计划III（影像技术） 生理功能）。